Immunopathology In Toxicology And Drug Development

Author : George A. Parker
Publisher : Springer
ISBN 13 : 3319473859
Total Pages : 826 pages
Book Rating : 4.57/5 ( download)

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Download or read book Immunopathology in Toxicology and Drug Development written by George A. Parker and published by Springer. This book was released on 2017-03-27 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

Author : George A. Parker
Publisher : Springer
ISBN 13 : 3319473778
Total Pages : 670 pages
Book Rating : 4.72/5 ( download)

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Download or read book Immunopathology in Toxicology and Drug Development written by George A. Parker and published by Springer. This book was released on 2017-03-28 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

Author : Danuta J. Herzyk
Publisher : John Wiley & Sons
ISBN 13 : 0470386371
Total Pages : 433 pages
Book Rating : 4.78/5 ( download)

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Download or read book Immunotoxicology Strategies for Pharmaceutical Safety Assessment written by Danuta J. Herzyk and published by John Wiley & Sons. This book was released on 2008-11-21 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference which provides an overview of the current and recently introduced methodologies for testing the immunotoxic risks in drug candidates Helps readers understand the significance of the methods and approaches to immunotoxicology testing Aids drug scientists in industry and regulatory areas to consolidate approaches to immunotox testing Offers a definitive assessment of nonclinical models to study the toxic impacts (bio)pharmaceuticals can have on the immune system Includes chapter authors from across the pharma industry, bringing a real-world and applied perspective to immunotox testing

Author : Thomas J. Steinbach
Publisher : Springer Nature
ISBN 13 : 1493997777
Total Pages : 919 pages
Book Rating : 4.70/5 ( download)

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Download or read book Toxicologic Pathology for Non-Pathologists written by Thomas J. Steinbach and published by Springer Nature. This book was released on 2019-10-31 with total page 919 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.

Author :
Publisher : Elsevier
ISBN 13 : 0081006128
Total Pages : 8639 pages
Book Rating : 4.22/5 ( download)

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Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Author : Mohammad Tariqur Rahman
Publisher : John Wiley & Sons
ISBN 13 : 1119893003
Total Pages : 277 pages
Book Rating : 4.04/5 ( download)

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Download or read book Immunology for Dentistry written by Mohammad Tariqur Rahman and published by John Wiley & Sons. This book was released on 2023-09-05 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand the fundamentals of oral immunology with this accessible reference Immunology for Dentistry fulfils the need for a comprehensive overview of oral immunology and its key aspects for dental medicine. Its broad-based and accessible coverage introduces readers to all essential elements of oral immunology, from mechanisms of the immune system through to specific diseases and pathogens and their interactions with the immune system. This thorough text will provide an understanding of the link between the oral immune stem and oral microbiome as contributors to oral health. Readers will also find: A thorough introduction to the basic principles of immunology and immune response Detailed coverage of subjects including stem cell immunology, periodontitis, hormone modulation in periodontal inflammation and more Color diagrams demonstrating key concepts Authored by a team of international experts, Immunology for Dentistry provides a valuable approach to the fundamental and clinical aspects of immunology. It is a useful reference for dental students, teachers, and researchers, and will also be of interest to practicing dentists and specialists.

Author : Pritam S. Sahota
Publisher : CRC Press
ISBN 13 : 0429658060
Total Pages : 672 pages
Book Rating : 4.68/5 ( download)

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Download or read book The Illustrated Dictionary of Toxicologic Pathology and Safety Science written by Pritam S. Sahota and published by CRC Press. This book was released on 2019-04-26 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists. With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings. The IDTP consists of four major areas: 1. A-Z Dictionary of Pathology encompassing all organ systems, together with relevant non-pathology terms supported by references in "For Further Reading" sections. 2. Appendix 1: An Overviews of Drug Development, Nonclinical Safety & Toxicologic Pathology, and Important/Special Topics. 3. Appendix 2: Diagnostic Criteria of for Proliferative Proliferative Lesions in Rodents (Rat and Mouse) and Selected Non-Rodent Laboratory Species containing illustrations with detailed references and links to source material. 4) Appendix 3: Mini-Atlas of Organ System Anatomy and Histology to help re-acquaint the non-pathologist safety scientist with many normal anatomical structures. The editors and contributing scientists (board-certified veterinary pathologists, board-certified toxicologists, allied health safety scientists, health regulatory representatives) have experience from bench-level pathology and toxicology to managing global preclinical safety units in leading pharmaceutical companies. They have considerable experience mentoring pharmaceutical industry project team members, interacting with industry clinicians and representatives of decision-making bodies within the industry, as well as with global health authorities, such as the FDA and EMA. These activities convinced them of the necessity for and usefulness of the IDTP. As experts in their field, they have undertaken the hard work of writing and compiling the information, making the IDTP an exceptional, go-to reference. *Illustrations Editor: Gregory Argentieri

Author : Alys Bradley
Publisher : Academic Press
ISBN 13 : 012813089X
Total Pages : 628 pages
Book Rating : 4.96/5 ( download)

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Download or read book Spontaneous Pathology of the Laboratory Non-human Primate written by Alys Bradley and published by Academic Press. This book was released on 2023-06-20 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spontaneous Pathology of the Laboratory Non-human Primate serves as a "go to" resource for all pathologists working on primates in safety assessment studies. In addition, it helps diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathologies when assigning cause of death to species in zoological collections. Primate species included are rhesus, cynomolgus macaques and marmosets. Multi-authored chapters are arranged by organ system, thus providing the necessary information for continued research.Pathologists often face a lack of suitable reference materials or historical data to determine if pathologic changes they are observing in monkeys are spontaneous or a consequence of other treatments or factors. Contains color illustrations that depict the most common lesions to augment descriptions Covers descriptions that are compliant with the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) guidelines set forth by the Society of Toxicologic Pathology (STP) Provides pathologists with common terms that are compliant with the FDA’s Standard for Exchange of Nonclinical Data (SEND) guidelines

Author : Joanna Kwak-Kim
Publisher : Academic Press
ISBN 13 : 0323908063
Total Pages : 457 pages
Book Rating : 4.61/5 ( download)

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Download or read book Immunology of Recurrent Pregnancy Loss and Implantation Failure written by Joanna Kwak-Kim and published by Academic Press. This book was released on 2022-07-03 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology of Recurrent Pregnancy Loss provides doctors and immunologists with the information they need to help couples who experience recurrent pregnancy losses. Sections cover unexplained infertility, repeated in vitro fertilization, embryo transfer failures, history of second or third trimester pregnancy losses of unknown cause, or pregnancy with a history of or active autoimmune and/or alloimmune disease. Reproductive failure (RF), including recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) is rather a syndrome than a disease caused by multiple etiologies, such as anatomical, endocrine, genetic, infectious, immunological, thrombotic and unexplained etiologies, hence this book strives to present the latest information. In 27 chapters, divided in 5 sections, the book introduces the current update of reproductive immunology topics in RF and provides systematic diagnostic guidelines, systemic and immune etiologies and therapeutic approaches. Provides detailed immunological background for understanding the etiology and management of reproduction failure Evaluates various immunological factors involved in the pathogenesis and management of reproduction failure Gives insights into various immunological and therapeutic approaches for reproduction failure

Author : Ali S. Faqi
Publisher : Elsevier
ISBN 13 : 0323984622
Total Pages : 1074 pages
Book Rating : 4.21/5 ( download)

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Download or read book A Comprehensive Guide to Toxicology in Nonclinical Drug Development written by Ali S. Faqi and published by Elsevier. This book was released on 2024-02-11 with total page 1074 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy Includes the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology