Immunoconjugate Therapy Of Hematologic Malignancies

Author : Steven T. Rosen
Publisher : Springer Science & Business Media
ISBN 13 : 1461530768
Total Pages : 293 pages
Book Rating : 4.63/5 ( download)

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Download or read book Immunoconjugate Therapy of Hematologic Malignancies written by Steven T. Rosen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hybridoma technique for producing monoclonal antibodies, developed by Drs. Kohler and Millstein in 1975, revolutionized the field of tumor immunology. It is now clear that there are antigens associated with or restricted to human neoplasms that have biologic significance. Monoclonal antibodies have already been demonstrated to have great immunodiagnostic value and it is anticipated that they will become a component of our therapeutic armamentarium. Most investigators in the field, however, feel that the true potential of monoclonal antibodies in cancer therapy remains to be determined. Clearly the most encouraging results have been witnessed in the treatment of hematologic malignancies. This volume of CANCER TREATMENT AND RESEARCH explores the current state of the art of immunoconjugate therapy of hematologic malignancies. Immunoconjugate Therapy of Hematologic Malignancies provides an update of a rapidly advancing field. The preliminary experience of a number of investigators suggests a role for targeted therapy in the treatment of hematologic malignancies. At the present time, immunoconjugates have, in most instances, been reserved for patients with advanced refractory disease. However, it is anticipated in the future that these reagents will be utilized as a complement to traditional therapy or as post-remission consolidation in patients with minimal residual disease. The obstacles have been defined; solutions will require further research and creative imagination.

Author : Bruce D. Cheson
Publisher :
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.88/5 ( download)

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Download or read book Monoclonal Antibody Therapy of Hematologic Malignancies written by Bruce D. Cheson and published by . This book was released on 2001 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Owen A. O'Connor
Publisher : John Wiley & Sons
ISBN 13 : 1119824540
Total Pages : 501 pages
Book Rating : 4.41/5 ( download)

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Download or read book Precision Cancer Therapies, Volume 2: Immunologic Approaches for the Treatment of Lymphoid Malignancies written by Owen A. O'Connor and published by John Wiley & Sons. This book was released on 2024-04-29 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents timely and authoritative information on the development of precision cancer therapies as applied to hematologic malignancies The Precision Cancer Therapies series focuses on how to understand and translate fundamental basic science into information that can be directly applied to patients to advance care. Each volume of the series integrates the relevant biological concepts and principles necessary for translating this science to practitioners of this science. Precision Cancer Therapies, Volume Two, focuses on sophisticated immunotherapies targeting cancers affecting the blood, bone marrow, and lymph nodes. Edited and authored by the foremost authorities in the field, this comprehensive reference text covers targeting of cell surface receptors, antibody-drug conjugates (ADC), targeting immune checkpoint, targeting macrophages, EBV-directed immunotherapies, tumor-associated antigens (TAA), and chimeric antigen receptor T-cells (CAR-T). Divided into nine sections, Volume Two includes an overview of the history of immunotherapy development in cancer, as well as a concluding section addressing the mechanistic basis and role of immunomodulatory drugs, analytical tools to quantitate immune-mediated effects, and other topics in immunotherapy. Chapters on specific therapeutics or therapeutic classes include a basic explanation of the underlying pathway and target, the pharmacology of the drug/class, relevant preclinical and clinical data, and discussion of clinical management and potential predictive biomarkers of response. This book also: Delivers a definitive, state-of-the-art review of the relevant biology and its importance in the broader context of cancer biology Focuses on agents that mediate cell killing in lymphoma through a variety of immunologic mechanisms Covers FDA-approved drugs and their indications, as well as drugs currently in development Provides information on monotherapy and combination therapy, summary tables of trials, and discussion of toxicity and efficacy Includes boxed sections highlighting major unique points about the information in the chapter Precision Cancer Therapies, Volume Two: Immunologic Approaches for the Treatment of Lymphoid Malignancies, From Concept to Practice is an indispensable resource for medical, scientific, and allied medical professionals, advanced students, and interested general readers with background knowledge in the subject.

Author :
Publisher :
ISBN 13 :
Total Pages : 46 pages
Book Rating : 4.80/5 ( download)

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Download or read book Monoclonal Antibody Therapy for Hematologic Malignancies written by and published by . This book was released on 2000 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Martin S. Tallman
Publisher : Springer Science & Business Media
ISBN 13 : 0585385718
Total Pages : 383 pages
Book Rating : 4.16/5 ( download)

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Download or read book Diagnostic and Therapeutic Advances in Hematologic Malignancies written by Martin S. Tallman and published by Springer Science & Business Media. This book was released on 2007-11-23 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is no field of medicine in which advances in therapy have been so closely linked to a better understanding of molecular medicine than in the area of hematologic malignancies. Diagnostic and Therapeutic Advances in Hematologic Malignancies will provide practitioners and academic clinicians with a better understanding of the constant evolving concepts in this area.

Author : John C. Byrd
Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.28/5 ( download)

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Download or read book Monoclonal Antibody Therapy for Hematologic Malignancies written by John C. Byrd and published by . This book was released on 2003 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author :
Publisher :
ISBN 13 :
Total Pages : 46 pages
Book Rating : 4.80/5 ( download)

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Download or read book Monoclonal Antibody Therapy for Hematologic Malignancies written by and published by . This book was released on 2000 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : American Society of Hematology
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.76/5 ( download)

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Download or read book Monoclonal Antibody Therapies for Hematologic Malignancies written by American Society of Hematology and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : David A. Sallman, MD
Publisher : Springer Publishing Company
ISBN 13 : 0826149774
Total Pages : 571 pages
Book Rating : 4.70/5 ( download)

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Download or read book Handbook of Hematologic Malignancies written by David A. Sallman, MD and published by Springer Publishing Company. This book was released on 2020-12-19 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised and updated second edition of Handbook of Hematologic Malignancies continues to be an essential and "go-to" resource for the busy hematologist, hematologic oncologist, hematopathologist, oncology advanced practice provider, oncology nurse, and trainee. Concisely organized, each chapter provides the most current, need-to-know points of diagnosis, prognosis, therapeutic management, and clinical trial opportunities for each hematological malignancy. Chapters are complete with richly illustrated figures to highlight the hematopathologic characteristics of diseases in addition to helpful tables on differential diagnosis, prognostic scoring systems, molecular profiles, and therapeutic options. A new case-based chapter concludes the handbook with clinical cases designed to test a clinician's knowledge of pathologic diagnosis and clinical presentation of diseases covered in the book. With over twenty new FDA-approved indications since publication of the first edition, including breakthroughs with CAR-T therapy, and other evidence-based treatment options for patients with hematologic disease, this book serves as quick reference to practice changing information on challenging diagnostic dilemmas, frontline and refractory treatment scenarios, and more. The subspecialty field of hematologic oncology is ever-changing and expanding with available treatment options and this second edition keeps the busy clinician abreast of recent findings and their impact on evidence-based treatment and management. Written by experienced clinicians at the world-renowned Moffitt Cancer Center in Tampa, Florida, as well as contributions from leading academicians, hematologists, and oncologists throughout the country, this unique handbook is packed with authoritative knowledge and clinical insight into all known hematologic cancers. Key Features: Includes seven new chapters covering CAR-T and novel therapeutic options including CD19 CAR-T therapy, novel cellular therapies, cytokine release syndrome, cancer associated thrombosis, and more Comprises compact and updated disease-site chapters describing new standards of care and management considerations in bullet point format with key references Highlights important diagnostic tools that assist with conducting key differential diagnoses and unveiling answers to diagnostic dilemmas Provides updates of potential practice-changing clinical trials and paradigm shifting treatment considerations in each disease-based chapter

Author : Barth Hoogstraten
Publisher : Springer
ISBN 13 : 9783540162933
Total Pages : 0 pages
Book Rating : 4.33/5 ( download)

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Download or read book Hematologic Malignancies written by Barth Hoogstraten and published by Springer. This book was released on 1986-09-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new series on the treatment of cancer is sponsored by the VICe. The editors and authors feel strongly that more standardiza tion is needed on a worldwide basis in cancer therapy. This, of course, is only possible if experts from all countries subscribe to a joint policy of making their treatment designs available to practising oncologists all over the world. Current Treatment of Cancer will discuss all the equipment and methods now in use in cancer therapy. It will cover all types of cancer, thus providing the reader with comprehensive information on cancer management. In recent decades there has been a tremendous improvement in the treatment of cancer, and there is hope for even further success in this fight. We are convinced that this series will help us to make a concerted response to the challenge of cancer. VICC Treatment and Rehabilitation Programme Ismail Elsebai Chairman VII Preface During the past two decades we have witnessed an exciting evolution in the un derstanding and management of hematologic malignancies. The number of drugs available 20 years ago for the treatment of acute leukemia was so small that the disease in children and in adults could be discussed within one chapter. Since then, rapid progress has been made in the management of childhood leukemia, making for a much better prognosis. Over the past 10 years we have seen the same developments in respect of leukemia in adults.