Imidazole Based Drug Discovery

Author : Shikha Agarwal
Publisher : Elsevier
ISBN 13 : 0323903630
Total Pages : 374 pages
Book Rating : 4.39/5 ( download)

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Download or read book Imidazole-Based Drug Discovery written by Shikha Agarwal and published by Elsevier. This book was released on 2021-12-02 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imidazole-Based Drug Discovery covers all categories of imidazole and its derivatives, synthesis, pharmacological applications and drug-based studies. Imidazole scaffolds act as a channel between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. This book provides detailed coverage of several greener synthetic protocols and pharmacological applications of imidazole derivatives that are useful to researchers working on designing more promising clinical lead compounds with this scaffold. It also includes information on past decades of research on the synthesis and biological applications of imidazole derivatives. This is an ideal resource for researchers in organic chemistry both in academic and industrial settings, as well as postgraduates in chemistry and medicinal chemistry. Reviews the most current developments and future perspectives of imidazole on different disease therapies to achieve the ultimate goal of disease eradication Discusses the role of imidazole in contemporary science, technological innovation, drug development, critical challenges and future research directions Covers emerging trends on different eco-benign pathways to synthesize imidazole derivatives for the development of simpler synthetic protocols

Author : Izet Kapetanović
Publisher : BoD – Books on Demand
ISBN 13 : 9533076151
Total Pages : 544 pages
Book Rating : 4.57/5 ( download)

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Download or read book Drug Discovery and Development written by Izet Kapetanović and published by BoD – Books on Demand. This book was released on 2011-12-16 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.

Author : Lawton Anthony II Seal
Publisher :
ISBN 13 :
Total Pages : 114 pages
Book Rating : 4.04/5 ( download)

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Download or read book Studies Towards the Total Synthesis of Imidazole-containing Natural Products written by Lawton Anthony II Seal and published by . This book was released on 2019 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nature has inspired man in all aspects of life, chemistry included. The first antibiotic ever discovered came from nature, and since then, chemists have been probing nature for insights to guide drug discovery and development. Alkaloids are a class of naturally occurring molecules which contain nitrogen atoms and can be found in all forms of life. Imidazole is common structural unit found in many natural molecules, from the simple amino acid histamine to more complex structures like the marine sponge derived alkaloid palau'amine. Many imidazole-containing natural products are biologically active, such as inhibiting the growth of tumors, possessing antibacterial properties, and influencing signaling pathways of cells like an inflammatory response. Access to large quantities of these molecules would aid medical science in drug discovery and design, potentially impacting the overall quality of life for all. It is therefore essential for the chemical community to pursue the synthesis of natural products not only to gain more knowledge in the overall science, allowing for better isolation,characterization, and synthesis of molecules, but also to better the quality of life and health as a whole.Chapter 1 of this dissertation describes the isolation and characterization of spiroleucettadine and terrazoanthines A-C. It further describes, in detail, the unsuccessful attempts to synthesis spiroleucettadine, which prompted its structural revision, and the only reported synthesis of the revised structure.Chapter 2 focuses on our approach to the total synthesis of spiroleucettadine. Initially our strategy centered on employing a novel reaction discovered in our lab to help facilitate the construction of the spirocyclic center. However, we later found this route to not be viable,leading to a significant revision in our strategy.In chapter 3 describe our approach to total synthesis of terrazoanthines A-C. Besides its purification and structural assignment,there are no reports pertaining to this molecule in the literature. Of the 3 molecules, only one of them possesses multiple stereochemical centers. However, upon further examination of the core structure we proposed a concise synthetic route leading to not only all 3 molecule, all possible stereoisomers through the construction of a key symmetric intermediate.In chapter 4 we discuss the oxidative chemistry of tetrahydrobenzimidazole. The two oxidants used were dimethyldioxarine and oxaziridine. The results show the choice of oxidant, N-protecting group,and the functionalization at the C2-position can greatly affect the outcome of the reactions, leading to additions, cyclizations, and ring openings.

Author : M. R. Grimmett
Publisher : Academic Press
ISBN 13 : 9780080534459
Total Pages : 265 pages
Book Rating : 4.57/5 ( download)

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Download or read book Imidazole and Benzimidazole Synthesis written by M. R. Grimmett and published by Academic Press. This book was released on 1997-06-02 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imidazole and Benzimidazole Synthesis is a comprehensive survey of the known methods of syntheses and ring modification. It brings together the multitude of synthesis of the imidazole ring in a systemic way interms of specific bond formation, and recommends the most attractive synthetic approaches. It also collects non-ring-synthetic approaches to classes of compounds such as nitro-, halogeno-, and amino-imidazoles, and covers the synthesis of N-substituted compounds and preparations of specific isomers. The only book in print dealing specifically with this topic Comprehensive survey of the known methods of synthesis and ring modification Recommends the most attractive synthetic approaches

Author : P N Kourounakis
Publisher : CRC Press
ISBN 13 : 1134995296
Total Pages : 199 pages
Book Rating : 4.95/5 ( download)

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Download or read book Advanced Drug Design And Development: A Medicinal Chemistry Approach written by P N Kourounakis and published by CRC Press. This book was released on 1994-03-31 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reporting the rapidly growing field of rational drug design, this work is composed from a selected, topical range of chapters written by specialists in each field.

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.03/5 ( download)

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Download or read book Bioactive Heterocycles written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Maria Marinescu
Publisher : BoD – Books on Demand
ISBN 13 : 1789845521
Total Pages : 230 pages
Book Rating : 4.25/5 ( download)

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Download or read book Chemistry and Applications of Benzimidazole and its Derivatives written by Maria Marinescu and published by BoD – Books on Demand. This book was released on 2019-10-02 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Finding new strategies for synthesizing benzimidazole derivatives and functionalizing the benzimidazole core has proved to be important due to the compound's various applications in medicine, chemistry, and other areas. The multitude of benzimidazole derivatives marketed as drugs has led to intensive research in the field for the discovery of new biologically active structures. The general applications of benzimidazole derivatives in materials chemistry, electronics, technology, dyes, pigments, and agriculture open up new research horizons. This book guides the rational design of benzimidazole derivatives synthesis with certain applications. Chapters cover such topics as therapeutic use of benzimidazole in conditions like diabetes, viruses, and parasitic diseases; X-ray crystal structure of selected benzimidazole derivatives; benzimidazole compounds for cancer therapy; and others.

Author : Jie Jack Li
Publisher : John Wiley & Sons
ISBN 13 : 1118354435
Total Pages : 688 pages
Book Rating : 4.38/5 ( download)

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Download or read book Heterocyclic Chemistry in Drug Discovery written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2013-04-26 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Author : Stefan Bräse
Publisher : Royal Society of Chemistry
ISBN 13 : 1782620303
Total Pages : 486 pages
Book Rating : 4.03/5 ( download)

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Download or read book Privileged Scaffolds in Medicinal Chemistry written by Stefan Bräse and published by Royal Society of Chemistry. This book was released on 2015-11-20 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.

Author : Li Di
Publisher : Elsevier
ISBN 13 : 0080557619
Total Pages : 549 pages
Book Rating : 4.18/5 ( download)

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Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint