Human Toxicology Of Chemical Mixtures

Author : Harold Zeliger
Publisher : William Andrew
ISBN 13 : 9781437734645
Total Pages : 574 pages
Book Rating : 4.42/5 ( download)

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Download or read book Human Toxicology of Chemical Mixtures written by Harold Zeliger and published by William Andrew. This book was released on 2011-06-24 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this important reference work, Zeliger catalogs the known effects of chemical mixtures on the human body and also proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The author’s focus is on illnesses that ensue following exposures to mixtures of chemicals that cannot be attributed to any one component of the mixture. In the first part the mechanisms of chemical absorption at a molecular and macromolecular level are explained, as well as the body’s methods of defending itself against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed, looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which includes numerous case studies, examines specific effects of particular mixtures on particular body systems and organs and presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be. Part IV covers regulatory requirements and the need to adjust recommended exposure levels for products containing mixtures. It also contains recommendations on how to limit exposure to mixtures in the products we use and on how to limit release of mixtures into the environment. Providing brief summaries of each mixture and its effects, Zeliger provides a comprehensive reference, a jumping off point for professionals (with extensive chapter bibliographies) and an introduction to the topic for those studying traditional toxicology. Addressing many inadequately understood illnesses and conditions such as asthma, infertility and cancer, it will also be of interest to health professionals, environmental scientists and lawyers. Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations - far too many to comprehensively catalog) A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientists New and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures

Author : Cornelis A. M. van Gestel
Publisher : CRC Press
ISBN 13 : 1439830096
Total Pages : 312 pages
Book Rating : 4.93/5 ( download)

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Download or read book Mixture Toxicity written by Cornelis A. M. van Gestel and published by CRC Press. This book was released on 2016-04-19 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an

Author : Cynthia V. Rider
Publisher : Springer
ISBN 13 : 3319562347
Total Pages : 556 pages
Book Rating : 4.46/5 ( download)

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Download or read book Chemical Mixtures and Combined Chemical and Nonchemical Stressors written by Cynthia V. Rider and published by Springer. This book was released on 2018-02-16 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the context of mixtures toxicology and risk assessment. Finally, the discussion will move beyond chemical mixtures to address incorporating non-chemical stressors into toxicity studies and cumulative risk assessments. Although exposure to multiple chemical and non-chemical stressors is the rule, not the exception, consideration of mixtures in toxicology and risk assessment continues to be a significant challenge. This book will be an essential resource for researchers and professionals in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics.

Author : Raymond S.H. Yang
Publisher : Elsevier
ISBN 13 : 1483289400
Total Pages : 745 pages
Book Rating : 4.03/5 ( download)

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Download or read book Toxicology of Chemical Mixtures written by Raymond S.H. Yang and published by Elsevier. This book was released on 2013-10-22 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although toxicologic studies in the laboratory often focus on a single chemical, in the larger world, mixtures of chemicals are routinely encountered. Toxicology of Chemical Mixtures examines the mechanisms of interactions and health effects stemming from chemical mixtures in the environment. Toxicologists, pharmacologists, environmental scientists, and professionals involved in environmental clean-ups will benefit from its content. Emphasis is on low-level, long-term exposure. Some of the issues addressed include Target organ toxicities in response to chemical mixture exposures Risk assessment and experimental approaches Case studies and special pollution problems Special pollution problems

Author : Cornelis A. M. van Gestel
Publisher : CRC Press
ISBN 13 : 9781439830086
Total Pages : 0 pages
Book Rating : 4.88/5 ( download)

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Download or read book Mixture Toxicity written by Cornelis A. M. van Gestel and published by CRC Press. This book was released on 2010-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology and classic human toxicology, Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology incorporates extensive reviews of exposure to toxicants, toxicokinetics and toxicodynamics, toxicity of mixtures, and risk assessment. The book examines developments in both fields, compares and contrasts their current state of the art, and identifies where one field can learn from the other. Each chapter provides an essential overview of the state of the art in both human and ecotoxicological mixture risk assessment, focusing on the work published in the last fifteen years. The coverage progresses from exposure to risk assessment, at each step identifying the special complications typically raised by mixtures. Based on in-depth discussions among specialists representing different disciplines and approaches, the chapters each address: Exposure — how to quantify the amounts of chemicals that may enter the living organism Kinetics, dynamics, and metabolism — how the chemicals enter an organism, travel within the organism, how they are metabolized and reach the target site, and explain development of toxicity with time Toxicity — what are the chemicals’ detrimental effects on the organism Test design and complex mixture characterization — how chemicals interact, how to measure effects of mixtures, and how to identify responsible chemicals Risk assessment — how to assess for risks in humans and the environment An unusual combination of different points of view on exposure to and risk assessment of chemical mixtures, this book summarizes current knowledge on combined effects of toxicant mixtures, information that is generally only available in a very fragmented form as individual journal papers. It identifies possible crosslinks and includes recommendations for mutual developments that can improve the state of knowledge on mixture toxicity and ultimately lead to better and more integrated risk assessment.

Author : Moiz Mumtaz
Publisher : John Wiley & Sons
ISBN 13 : 3527632115
Total Pages : 625 pages
Book Rating : 4.14/5 ( download)

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Download or read book Principles and Practice of Mixtures Toxicology written by Moiz Mumtaz and published by John Wiley & Sons. This book was released on 2011-05-23 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive treatment of the subject for more than a decade includes the latest research on nanoparticle toxicology. The practical handbook addresses all areas where toxic mixtures are encountered, from environmental via occupational to medical settings, giving special consideration to air and water, and to the specific requirements for study design in mixture toxicology. While no extensive prior knowledge or toxicological experience is required, the practice-oriented case studies and examples in the second part make this the ideal companion for the professional toxicologist in industry or healthcare institutions with little time for academic study.

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309112982
Total Pages : 300 pages
Book Rating : 4.87/5 ( download)

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Download or read book Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2007-12-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

Author : Elsa Nielsen
Publisher : CRC Press
ISBN 13 : 1420006940
Total Pages : 450 pages
Book Rating : 4.40/5 ( download)

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Download or read book Toxicological Risk Assessment of Chemicals written by Elsa Nielsen and published by CRC Press. This book was released on 2008-02-21 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk

Author :
Publisher :
ISBN 13 :
Total Pages : 94 pages
Book Rating : 4.63/5 ( download)

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Download or read book EPA 630/R written by and published by . This book was released on 1998 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309037786
Total Pages : 240 pages
Book Rating : 4.85/5 ( download)

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Download or read book Complex Mixtures written by National Research Council and published by National Academies Press. This book was released on 1988-02-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the laboratory, testing the toxic effects for a single compound is a straightforward process. However, many common harmful substances occur naturally as mixtures and can interact to exhibit greater toxic effects as a mixture than the individual components exhibit separately. Complex Mixtures addresses the problem of identifying and classifying complex mixtures, investigating the effect of exposure, and the research problems inherent in testing their toxicity to human beings. A complete series of case studies is presented, including one that examines the cofactors of alcohol consumption and cigarette smoke.