Hedgehog Gli Signaling In Human Disease

Author : Ariel Ruiz i Altaba
Publisher : Springer Science & Business Media
ISBN 13 : 0387337776
Total Pages : 240 pages
Book Rating : 4.77/5 ( download)

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Download or read book Hedgehog-Gli Signaling in Human Disease written by Ariel Ruiz i Altaba and published by Springer Science & Business Media. This book was released on 2007-06-24 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.

Author : Ariel Ruiz i Altaba
Publisher : Springer
ISBN 13 : 9780387506999
Total Pages : 0 pages
Book Rating : 4.93/5 ( download)

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Download or read book Hedgehog-Gli Signaling in Human Disease written by Ariel Ruiz i Altaba and published by Springer. This book was released on 2008-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.

Author : Jingwu Xie
Publisher : Springer Science & Business Media
ISBN 13 : 1441984356
Total Pages : 223 pages
Book Rating : 4.57/5 ( download)

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Download or read book Hedgehog signaling activation in human cancer and its clinical implications written by Jingwu Xie and published by Springer Science & Business Media. This book was released on 2011-04-30 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.

Author : Jamila I. Horabin
Publisher : Springer Science & Business Media
ISBN 13 : 158829692X
Total Pages : 267 pages
Book Rating : 4.24/5 ( download)

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Download or read book Hedgehog Signaling Protocols written by Jamila I. Horabin and published by Springer Science & Business Media. This book was released on 2007-09-13 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: In both vertebrates and invertebrates, Hedgehog signaling regulates the development of the tissues and structures of the body. In addition, many cancers and diseases arise as a result of misregulation of the pathway, which makes it an incredibly important system to understand. This volume examines various methods used in the analysis of the Hedgehog signaling pathway, bringing together different lines of analyses into one accessible and comprehensive text. This volume provides a single source for investigators, presenting several different experimental approaches, which are all varied and broad in nature, as well as procedures for a variety of different model systems. Researchers will find this volume to be an invaluble tool as they work towards deeper understanding of the underlying molecular events that the Hedgehog signaling pathway regulates.

Author : Michael W. Quick
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 322 pages
Book Rating : 4.95/5 ( download)

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Download or read book Transmembrane Transporters written by Michael W. Quick and published by Wiley-Liss. This book was released on 2002-09-09 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Families of transporters and their classification / Milton H. Saier, Jr. -- 2. Yeast as a model system for studying glucose transport / Eckhard Boles -- 3. Neurotransmitter transporters of drosophila / Martin G. Burg and William L. Pak -- 4. Transgenic mice in monoamine transporter research / Sara R. Jones -- 5. Searching for novel genetic variation in neurotransmitter transporters / Randy D. Blakely and Alexandra R. Belous -- 6. Non-viral gene transfer allows up- and down-expression of the brain serotonin transporter with functional consequences / Marie-Pascale Martres ... [et al.] -- 7. Methods in studying the regulation and trafficking of transmembrane transporters / Scott L. Deken, Dan Wang, and Michael W. Quick -- 8. Chemical modification strategies for structure-function studies / Gary Rudnick -- 9. Methanethiosulfonate reagent accessibility studies, cysteine scanning mutagenesis, protein overexpression and functional reconstitution / Ronald S. Kaplan -- 10. Peptide mapping of dopamine transporter ligand and substrate interaction sites / Margaret J. Lowe, Jon D. Gaffaney, and Roxanne A. Vaughan -- 11. Mass spectrometry of membrane transport proteins / Julian P. Whitelegge, H. Ronald Kaback and Johannes le Coutre -- 12. Amperometric recording of amphetamine-induced dopamine efflux / David Sulzer ... [et al.] -- 13. Voltage clamp and fluorometric techniques for studying glutamate transporter function / Anastassios Tzingounis, Hans Peter Larsson and Michael P. Kavanaugh -- 14. Studies of glial glutamate transporters in hippocampal microcultures / Steven Mennerick, Robert J. Cormier and Charles F. Zorumski -- 15. Imaging monoamine transporters in the brain / Hank F. Kung and Mei-Ping Kung -- 16. Measuring and modeling the spatiotemporal profile of GABA at the synapse / Linda S. Overstreet, Gary L. Westbrook and Mathew V. Jones

Author : Xiaochun Li
Publisher : Humana
ISBN 13 : 9781071617038
Total Pages : 0 pages
Book Rating : 4.36/5 ( download)

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Download or read book Hedgehog Signaling written by Xiaochun Li and published by Humana. This book was released on 2022-10-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book explores the technical breakthroughs with biophysical and cell biological approaches that have advanced the study of molecular mechanisms underlying the generation and transduction of the hedgehog (HH) signal, indicating the important role of sterols in this pathway. Within its pages, the volume examines techniques involving several key protein components in this pathway, including HH, the signaling ligand; Dispatched, a HH secretion regulator; Patched, the receptor of HH; Smoothened, the signal transducer used to transduce the HH signal across the plasma membrane; and GLI, the transcription factor to turn on HH target genes. Written in the highly successful Methods in Molecular Biology series format, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Hedgehog Signaling: Methods and Protocols provides researchers in clinical and basic science with a fresh and reliable reference for analyzing HH signal transduction through cell biological, biochemical, and biophysical approaches.

Author : A. Strain
Publisher : Springer Science & Business Media
ISBN 13 : 9401149321
Total Pages : 681 pages
Book Rating : 4.27/5 ( download)

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Download or read book Liver Growth and Repair written by A. Strain and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue.

Author : Peter Thorogood
Publisher :
ISBN 13 :
Total Pages : 274 pages
Book Rating : 4.06/5 ( download)

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Download or read book Craniofacial Development written by Peter Thorogood and published by . This book was released on 1988 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Jörg Reichrath
Publisher : Springer Nature
ISBN 13 : 3030462277
Total Pages : 428 pages
Book Rating : 4.77/5 ( download)

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Download or read book Sunlight, Vitamin D and Skin Cancer written by Jörg Reichrath and published by Springer Nature. This book was released on 2020-09-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.

Author : Robert Lanza
Publisher : Academic Press
ISBN 13 : 0080884970
Total Pages : 681 pages
Book Rating : 4.74/5 ( download)

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Download or read book Essentials of Stem Cell Biology written by Robert Lanza and published by Academic Press. This book was released on 2009-06-05 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered. Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries Contributions by Nobel Laureates and leading international investigators Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references