Heart Proteomics

Author : Giulio Agnetti
Publisher : Springer
ISBN 13 : 3319318284
Total Pages : 430 pages
Book Rating : 4.88/5 ( download)

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Download or read book Manual of Cardiovascular Proteomics written by Giulio Agnetti and published by Springer. This book was released on 2016-09-15 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book fulfils the need to keep up with the high number of innovations in proteomics, and at the same time to warn the readers about the danger of manufacturers and scientists claims around new technologies. Mass spectrometry stands as the core technology in proteomics. The emerging field of targeted proteomics and its potential applications in the cardiovascular arena are also reviewed and discussed. A concluding section highilghts the promise of proteomics in the light of these recent developments.​ As this technique and its applications have undergone remarkable advances in the past years, recent updates on proteomic applications are covered. Another key concept revealed by proteomic technologies is that the extent of protein post-translational modifications (PTMs) as well as their impact on the phenotype has been underestimated by pre-proteomics science. As such, part of the manual focuses on the emerging role of PTMs in basic cardiovascular sciences and in the clinics. In fact, there is an emerging consensus that the detailed annotation of protein PTMs could lead to a more in-depth representation of biological systems, translating into more specific targets for therapy as well as biomarkers. Moreover, a recent trend is so-called “targeted proteomics”. The approach was awarded the title of “Method of the Year” by Nature in 2013 (see the editorial by Vivien Marx in 1st issue of Nature in Jan 2013). According to a few proteomic scientists the emphasis should not be placed on generating long lists of proteins but lists of proteins with a true biological meaning.

Author : Fernando Vivanco
Publisher : Humana Press
ISBN 13 : 9781627033879
Total Pages : 262 pages
Book Rating : 4.74/5 ( download)

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Download or read book Heart Proteomics written by Fernando Vivanco and published by Humana Press. This book was released on 2013-04-20 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of proteomics to study complex diseases such as cardiovascular disease, the leading cause of death in developed countries, has grown exponentially in recent years. Proteomics is a rapidly expanding investigation platform in cardiovascular medicine and is becoming integrated and incorporated into cardiovascular research. The proteomics field continues to develop with major improvements in mass spectrometry instrumentation, methodology and data analysis. Heart Proteomics: Methods and Protocols complies a selection of techniques and methods that target the numerous processes implicated in the pathophysiology of heart. Chapters cover protocols and updated methods in the heart proteomic area with a particular focus on MS-based methods of protein and peptide quantification and the analysis of posttranslational modifications as well as descriptions of system biology approaches, which provide a better understanding of normal and pathological processes. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Heart Proteomics: Methods and Protocols is a representative selection of methods that will prove to be a useful resource for experienced proteomics practitioners and newcomers alike.

Author : Fernando Vivanco
Publisher : Springer Science & Business Media
ISBN 13 : 1597452149
Total Pages : 412 pages
Book Rating : 4.44/5 ( download)

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Download or read book Cardiovascular Proteomics written by Fernando Vivanco and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book presents protocols and strategies for proteomic evaluation of cardiovascular disease written by pioneering researchers in the field. Topics explored in this comprehensive volume include obtaining specific heart proteins, techniques for identifying risk biomarkers of atherome plaque rupture, analyzing the secretome of explanted endarterectomies cultured in vitro, and phage display techniques for deciphering the molecular diversity of blood vessels.

Author : Jennifer E. Van Eyk
Publisher : John Wiley & Sons
ISBN 13 : 3527605452
Total Pages : 423 pages
Book Rating : 4.53/5 ( download)

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Download or read book Proteomic and Genomic Analysis of Cardiovascular Disease written by Jennifer E. Van Eyk and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease - the number-one killer in the industrialized world. Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area.

Author : Fernando Vivanco
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.77/5 ( download)

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Download or read book Cardiovascular Proteomics written by Fernando Vivanco and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Cardiovascular Proteomics: Methods and Protocols" covers many of the aspects of the proteomic approach in the cardiovascular field. This volume takes the reader through the complete process of proteomic analysis, from the obtention of specific heart proteins (troponin I) to the new techniques of identifying risk biomarkers of atherome plaque rupture analyzing the secretome of explanted endartrectomies cultured in vitro or the application of phage display techniques to decipher the molecular diversity of blood vessels.

Author : Michael Hamacher
Publisher : John Wiley & Sons
ISBN 13 : 9783527312269
Total Pages : 392 pages
Book Rating : 4.69/5 ( download)

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Download or read book Proteomics in Drug Research written by Michael Hamacher and published by John Wiley & Sons. This book was released on 2006-03-31 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.

Author : Ángel García-Alonso
Publisher : John Wiley & Sons
ISBN 13 : 0470463376
Total Pages : 432 pages
Book Rating : 4.76/5 ( download)

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Download or read book Platelet Proteomics written by Ángel García-Alonso and published by John Wiley & Sons. This book was released on 2011-05-31 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.

Author : Tsz Kwong Man
Publisher : BoD – Books on Demand
ISBN 13 : 9533078324
Total Pages : 454 pages
Book Rating : 4.28/5 ( download)

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Download or read book Proteomics written by Tsz Kwong Man and published by BoD – Books on Demand. This book was released on 2012-02-10 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical research has entered a new era of characterizing a disease or a protein on a global scale. In the post-genomic era, Proteomics now plays an increasingly important role in dissecting molecular functions of proteins and discovering biomarkers in human diseases. Mass spectrometry, two-dimensional gel electrophoresis, and high-density antibody and protein arrays are some of the most commonly used methods in the Proteomics field. This book covers four important and diverse areas of current proteomic research: Proteomic Discovery of Disease Biomarkers, Proteomic Analysis of Protein Functions, Proteomic Approaches to Dissecting Disease Processes, and Organelles and Secretome Proteomics. We believe that clinicians, students and laboratory researchers who are interested in Proteomics and its applications in the biomedical field will find this book useful and enlightening. The use of proteomic methods in studying proteins in various human diseases has become an essential part of biomedical research.

Author : Toru Suzuki
Publisher : Elsevier Health Sciences
ISBN 13 : 0323566421
Total Pages : pages
Book Rating : 4.21/5 ( download)

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Download or read book Biomarkers for Heart Failure, An Issue of Heart Failure Clinics, E-Book written by Toru Suzuki and published by Elsevier Health Sciences. This book was released on 2017-11-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Heart Failure Clinics, edited by Dr. Toru Suzuki, will cover Biomarkers for Heart Failure, including but not limited to Proenkephalin, B-type and mid-regional pro atrial natriuretic peptides , N-terminal B-type natriuretic peptide, Soluble T2, Adrenomedullin, Copeptin, Non-Coding RNAs, Troponin, Growth differentiation factor (GDF-15) , Galectin-3, Proteomic biomarkers, and Metabolic biomarkers .

Author : David A. Morrow
Publisher : Springer Science & Business Media
ISBN 13 : 1597450510
Total Pages : 640 pages
Book Rating : 4.15/5 ( download)

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Download or read book Cardiovascular Biomarkers written by David A. Morrow and published by Springer Science & Business Media. This book was released on 2010-04-28 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the four pages committed to a discussion of myocardial infarction in the first edition of Harrison’s Principles of Internal Medicine, published in 1950, there was no mention of use of the laboratory for management of patients. Thirty years later, when the first edition of Braunwald’s Heart Disease, A Textbook of Cardiovascular Medicine was published, 2 out of the 1943 pages in the text contained a discussion of the laboratory examinations in acute myocardial infarction. Our knowledge base of the multitude of ways that physicians can and should use the clinical chemistry laboratory has expanded dramatically since these classic texts were published. The nomenclature has changed: terms such as “cardiac enzymes” have given way to “cardiac biomarkers. ” The number of assays has multiplied, and the operating characteristics of available assays are impr- ing at a gratifying but dizzying rate. We now use biomarkers to diagnose cardiovascular diseases and also to frame our treatment strategies. Thus, there is a clear need for a scholarly compilation of the state of the art of cardiac biomarkers. Dr. David Morrow has expertly edited an authoritative book that answers this need. The 34 chapters in Cardiovascular Biomarkers: Pathophysiology and Disease Mana- ment were written by a group of individuals who are internationally recognized thought leaders and experts in clinical and laboratory medicine.