Handbook Of Pharmacokinetic Pharmacodynamic Correlation

Author : Hartmut Derendorf
Publisher : CRC Press
ISBN 13 : 1000012727
Total Pages : 742 pages
Book Rating : 4.29/5 ( download)

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Download or read book Handbook of Pharmacokinetic/Pharmacodynamic Correlation written by Hartmut Derendorf and published by CRC Press. This book was released on 2019-06-04 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1995: Combining the established disciplines of pharmacokinetics (PK), the relationship between drug concentration and time, and pharmacodynamics (PD), the relationship between drug effects and concentration, this handbook examines the relevant relationship between drug effects and time.

Author : Hartmut Derendorf
Publisher : CRC Press
ISBN 13 : 1000005909
Total Pages : 496 pages
Book Rating : 4.05/5 ( download)

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Download or read book Handbook of Pharmacokinetic/Pharmacodynamic Correlation written by Hartmut Derendorf and published by CRC Press. This book was released on 2019-06-04 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1995: Combining the established disciplines of pharmacokinetics (PK), the relationship between drug concentration and time, and pharmacodynamics (PD), the relationship between drug effects and concentration, this handbook examines the relevant relationship between drug effects and time.

Author : Peter L. Bonate
Publisher : Springer Science & Business Media
ISBN 13 : 1441994858
Total Pages : 634 pages
Book Rating : 4.51/5 ( download)

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Download or read book Pharmacokinetic-Pharmacodynamic Modeling and Simulation written by Peter L. Bonate and published by Springer Science & Business Media. This book was released on 2011-07-01 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.

Author : Ronald D. Schoenwald
Publisher : CRC Press
ISBN 13 : 1420010085
Total Pages : 430 pages
Book Rating : 4.84/5 ( download)

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Download or read book Pharmacokinetics in Drug Discovery and Development written by Ronald D. Schoenwald and published by CRC Press. This book was released on 2002-03-06 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existi

Author : Rajesh Krishna
Publisher : Springer Science & Business Media
ISBN 13 : 9780306477669
Total Pages : 576 pages
Book Rating : 4.61/5 ( download)

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Download or read book Applications of Pharmacokinetic Principles in Drug Development written by Rajesh Krishna and published by Springer Science & Business Media. This book was released on 2004 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a collection of articles that representindividual and expert perspectives in both preclinical and clinicaldevelopment, including case studies on real-life examples ofsuccessful drugs that add value to the pharmacokinetic principleslearned and applied. Unlike existing books that focus onpharmacokinetic theory, the current book emphasizes application ofpharmacokinetic principles in new drug development.

Author : Younggil Kwon
Publisher : Springer Science & Business Media
ISBN 13 : 0306468204
Total Pages : 302 pages
Book Rating : 4.09/5 ( download)

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Download or read book Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists written by Younggil Kwon and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Author : Johan Gabrielsson
Publisher : CRC Press
ISBN 13 : 9789186274924
Total Pages : 926 pages
Book Rating : 4.29/5 ( download)

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Download or read book Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition written by Johan Gabrielsson and published by CRC Press. This book was released on 2001-11-30 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.

Author : Wolfgang A. Ritschel
Publisher : American Pharmacists Association (APhA)
ISBN 13 :
Total Pages : 590 pages
Book Rating : 4.53/5 ( download)

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Download or read book Handbook of Basic Pharmacokinetics-- Including Clinical Applications written by Wolfgang A. Ritschel and published by American Pharmacists Association (APhA). This book was released on 1999 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1976, this handbook is a consolidation of principles and techniques for practitioners, researchers and students involved in the various applications of pharmacokinetics. Twenty-six of the previous edition's 37 chapters have been revised. A new chapter entitled Extracorporeal Methods of Drug Removal addresses the clinical pharmacokinetic challenges that accompany renal replacement therapy. Pharmacokinetic data profiles for an additional 128 drugs have been added to the appendix, which now provides accessible information on 426 drugs.

Author :
Publisher :
ISBN 13 :
Total Pages : 730 pages
Book Rating : 4.42/5 ( download)

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Download or read book International Journal of Clinical Pharmacology and Therapeutics written by and published by . This book was released on 2003 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Edythe D. London
Publisher : Routledge
ISBN 13 : 1351439332
Total Pages : 454 pages
Book Rating : 4.36/5 ( download)

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Download or read book Imaging Drug Action in the Brain written by Edythe D. London and published by Routledge. This book was released on 2017-11-22 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.