Handbook Of Downstream Processing

Author : E. Goldberg
Publisher : Springer Science & Business Media
ISBN 13 : 9400915632
Total Pages : 745 pages
Book Rating : 4.33/5 ( download)

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Download or read book Handbook of Downstream Processing written by E. Goldberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last two decades have seen a phenomenal growth of the field of genetic or biochemical engineering and have witnessed the development and ultimately marketing of a variety of products-typically through the manipulation and growth of different types of microorganisms, followed by the recovery and purification of the associated products. The engineers and biotechnologists who are involved in the full-scale process design of such facilities must be familiar with the variety of unit operations and equipment and the applicable regulatory requirements. This book describes current commercial practice and will be useful to those engineers working in this field in the design, construction and operation of pharmaceutical and biotechnology plants. It will be of help to the chemical or pharmaceutical engineer who is developing a plant design and who faces issues such as: Should the process be batch or continuous or a combination of batch and continuous? How should the optimum process design be developed? Should one employ a new revolutionary separation which could be potentially difficult to validate or use accepted technology which involves less risk? Should the process be run with ingredients formulated from water for injection, deionized water, or even filtered tap water? Should any of the separations be run in cold rooms or in glycol jacketed lines to minimize microbial growth where sterilization is not possible? Should the process equipment and lines be designed to be sterilized in-place, cleaned-in-place, or should every piece be broken down, cleaned and autoclaved after every turn?

Author : M. S. Verrall
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.55/5 ( download)

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Download or read book Downstream Processing of Natural Products written by M. S. Verrall and published by John Wiley & Sons. This book was released on 1996-08-06 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products, broadly defined as high value chemical entities derived from plants or microbial sources, have been known and exploited for many years. In recent years, as the need for higher potency and predictability of such products has increased, more sophisticated concentration and isolation procedures have been developed. With the passage of time, such procedures have been rationalized in terms of scientific principles but, in general, theory has followed behind practice, leading at any given time to an absence from the literature of methods which are truly state of the art. Downstream Processing of Natural Products: A Practical Handbook is a highly practical manual which addresses this issue, and guides researchers and industrial workers through the many potential pitfalls of natural product isolation. The contributors to this volume, all of whom have wide practical experience in this field, present state-of-the-art techniques and observations. The three main stages of natural product purification are covered, namely product release, capture, and purification, and both proteins and secondary metabolites are covered. There is special mention of the requirements of the regulatory authorities with respect to Good Manufacturing Practice, and practical guidance is given on scale-up procedures and process scale instrumentation. Downstream Processing of Natural Products: A Practical Handbook will provide essential practical guidance to all those involved in natural product isolation. This includes academic and industrial researchers, postgraduate students and technicians working in the biotechnology field.

Author : Gunter Jagschies
Publisher : Elsevier
ISBN 13 : 0080554512
Total Pages : 383 pages
Book Rating : 4.18/5 ( download)

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Download or read book Handbook of Process Chromatography written by Gunter Jagschies and published by Elsevier. This book was released on 2007-12-08 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers. Updates include: - sources and productivity - types of products made today - experiences in clinical and licensed products - economics - current status of validation - illustrations and tables - automated column packing - automated systems New topics include: - the use of disposables - multiproduct versus dedicated production - design principles for chromatography media and filters - ultrafiltration principles and optimization - risk assessments - characterization studies - design space - platform technologies - process analytical technologies (PATs) - biogenerics - comparability assessments Key Features: - new approaches to process optimiaztion - use of patform technologies - applying risk assessment to process design

Author : Sanjay Sahay
Publisher : Academic Press
ISBN 13 : 0128231335
Total Pages : 692 pages
Book Rating : 4.33/5 ( download)

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Download or read book Handbook of Biofuels written by Sanjay Sahay and published by Academic Press. This book was released on 2021-10-31 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Biofuels looks at the many new developments in various type of bioenergy, along with the significant constraints in their production and/or applications. Beyond introducing current approaches and possible future directions of research, this title covers sources and processing of raw materials to downstream processing, constraints involved and research approaches to address and overcome these needs. Different combinations of products from the biorefinery are included, along with the material to answer questions surrounding the optimum process conditions for conversion of different feedstocks to bioenergy, the basis for choosing conversion technology, and what bioenergy products make economic sense. With chapters on the techno-economic analysis of biofuel production and concepts and step-by-step approaches in bioenergy processing, the objective of this book is to present a comprehensive and all-encompassing reference about bioenergy to students, teachers, researchers and professionals. Reviews all existing and emerging technologies surrounding the production of advanced biofuels, including biodiesel and bioethanol Includes biofuel applications with compatible global application case studies Offers new pathways for converting biomass

Author : Giorgio Carta
Publisher : John Wiley & Sons
ISBN 13 : 352734666X
Total Pages : 440 pages
Book Rating : 4.60/5 ( download)

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Download or read book Protein Chromatography written by Giorgio Carta and published by John Wiley & Sons. This book was released on 2020-06-02 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: An all-in-one practical guide on how to efficiently use chromatographic separation methods Based on a training course that teaches the theoretical as well as practical aspects of protein bioseparation to bioprocess professionals, this fully updated and revised new edition offers comprehensive coverage of continuous chromatography and provides readers with many relevant examples from the biopharmaceutical industry. Divided into two large parts, Protein Chromatography: Process Development and Scale-Up, Second Edition presents all the necessary knowledge for effective process development in chromatographic bioseparation, both on small and large scale. The first part introduces chromatographic theory, including process design principles, to enable the reader to rationalize the set-up of a bioseparation process. The second part illustrates by way of case studies and sample protocols how the theory learned in the first part may be applied to real-life problems. Chapters look at: Downstream Processing of Biotechnology Products; Chromatography Media; Laboratory and Process Columns and Equipment; Adsorption Equilibrium; Rate Processes; and Dynamics of Chromatography Columns. The book closes with chapters on: Effects of Dispersion and Rate Processes on Column Performance; Gradient Elution Chromatography; and Chromatographic Column Design and Optimization. -Presents the most pertinent examples from the biopharmaceutical industry, including monoclonal antibodies -Provides an overview of the field along with design tools and examples illustrating the advantages of continuous processing in biopharmaceutical productions -Focuses on process development and large-scale bioseparation tasks, making it an ideal guide for the professional bioengineer in the biotech and pharma industries -Offers field-tested information based on decades of training courses for biotech and chemical engineers in Europe and the U.S. Protein Chromatography: Process Development and Scale-Up, Second Edition will appeal to biotechnologists, analytical chemists, chromatographers, chemical engineers, pharmaceutical industry, biotechnological industry, and biochemists.

Author : Krishna Kant Prasad
Publisher : PHI Learning Pvt. Ltd.
ISBN 13 : 812034040X
Total Pages : 374 pages
Book Rating : 4.04/5 ( download)

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Download or read book Downstream Process Technology: A New Horizon In Biotechnology written by Krishna Kant Prasad and published by PHI Learning Pvt. Ltd.. This book was released on 2010-01-30 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, biochemical process industry demands fast and economic processes for the partitioning and purification of biomolecules that give high yield and high purity of the product. An integral and cost intensive part of these processes is associated with downstream processing for product isolation and purification. The aim of this comprehensive text is to provide an insightful overview of the whole aspects of downstream processing for biochemical product recovery. Intended for undergraduate and postgraduate students of biotechnology and chemical engineering, this self-contained text includes the chapters based on the recent developments in the industry and academics. It covers the importance of the downstream processing in terms of its relevancy to modern days ever-changing consumer needs, process design criteria relevance to set objectives, and physicochemical factors that help to formulate the strategy to develop a configuration among the raw material, methodology and instruments. This overview is followed by different downstream processing steps. The text concludes with the discussion on stabilization of the product to improve the shelf life of the product. Key Features Includes detailed biological, mathematical, chemical and physical aspects of downstream processing. Distinguishes downstream processing from analytical bioseparation. Contains numerous illustrations and solved problems.

Author : Amos Richmond
Publisher : John Wiley & Sons
ISBN 13 : 1405172495
Total Pages : 587 pages
Book Rating : 4.93/5 ( download)

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Download or read book Handbook of Microalgal Culture written by Amos Richmond and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Microalgal Culture is truly a landmarkpublication, drawing on some 50 years of worldwide experience inmicroalgal mass culture. This important book comprisescomprehensive reviews of the current available information onmicroalgal culture, written by 40 contributing authors from aroundthe globe. The book is divided into four parts, with Part I detailingbiological and environmental aspects of microalgae with referenceto microalgal biotechnology and Part II looking in depth at majortheories and techniques of mass cultivation. Part III compriseschapters on the economic applications of microalgae, includingcoverage of industrial production, the use of microalgae in humanand animal nutrition and in aquaculture, in nitrogen fixation,hydrogen and methane production, and in bioremediation of pollutedwater. Finally, Part IV looks at new frontiers and includeschapters on genetic engineering, microalgae as platforms forrecombinant proteins, bioactive chemicals, heterotrophicproduction, microalgae as gene-delivery systems for expressingmosquitocidal toxins and the enhancement of marine productivity forclimate stabilization and food security. Handbook of Microalgal Culture is an essential purchasefor all phycologists and also those researching aquatic systems,aquaculture and plant sciences. There is also much of great use toresearchers and those involved in product formulation withinpharmaceutical, nutrition and food companies. Libraries in alluniversities and research establishments teaching and researchingin chemistry, biological and pharmaceutical sciences, food sciencesand nutrition, and aquaculture will need copies of this book ontheir shelves. Amos Richmond is at the Blaustein Institute for DesertResearch, Ben-Gurion University of the Negev, Israel.

Author : Nikolaos E. Labrou
Publisher :
ISBN 13 : 9781536143652
Total Pages : 0 pages
Book Rating : 4.50/5 ( download)

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Download or read book Handbook on Protein Purification written by Nikolaos E. Labrou and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are important biomolecules that are vital for the cellular structure and function. They perform a vast array of functions within organisms, including the catalysis of metabolic reactions, DNA replication, response to stimuli, and transporting molecules from one location to another. The technological advances in the omics areas (e.g., genomics, transcriptomics, proteomics, metagenomics, etc.) have dramatically increased the rate of discovering new proteins. Some of them hold large opportunities for innovative research and the development of commercial products and applications. It is worth noting that the global protein ingredients market is poised to grow over the next decade to reach approximately 58.49 billion USD by 2022, with the protein therapeutics market valuing around USD 315.9 billion by 2025. Interestingly, about seventy monoclonal antibody products will be on the market by 2020 with a combined worldwide sales of about 125 billion USD.The most significant parameter for the successful commercial exploitation of proteins rely on the development of an efficient and effective isolation and purification technology, known as protein downstream processing. Downstream processing refers to the technology that involves the isolation and production of purified products from natural sources such as animal tissues, plant tissues, microorganisms or fermentation broth. The most important element of this technology is the high purification processes, most important of which is chromatography and in particular affinity chromatography.This book provides information on the resent developments of protein downstream processing and deals with the information gained over the last years from the application of protein purification technologies on different research areas. Each chapter gives key examples that cover a wide range of diverse scientific disciplines in order to provide the reader with a representative sample of the current status of the field. The present book would definitely be an ideal source of scientific information to the advanced students, junior researchers, and scientists involved in cellular and molecular biology, biochemistry, microbiology, biotechnology and other related areas.

Author : Gunter Jagschies
Publisher : Elsevier
ISBN 13 : 0128125527
Total Pages : 1308 pages
Book Rating : 4.26/5 ( download)

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Download or read book Biopharmaceutical Processing written by Gunter Jagschies and published by Elsevier. This book was released on 2018-01-18 with total page 1308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. Offers a comprehensive, go-to reference for daily work decisions Covers both upstream and downstream processes Includes case studies that emphasize financial outcomes Presents summaries, decision grids, graphs and overviews for quick reference

Author : Uwe Gottschalk
Publisher : John Wiley & Sons
ISBN 13 : 1119126932
Total Pages : 849 pages
Book Rating : 4.35/5 ( download)

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Download or read book Process Scale Purification of Antibodies written by Uwe Gottschalk and published by John Wiley & Sons. This book was released on 2017-03-07 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing • Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification • Emphasizes antibodies and innovative chromatography methods for processing