Handbook Of Analysis Of Oligonucleotides And Related Products

Author : Jose V. Bonilla
Publisher : CRC Press
ISBN 13 : 1439819947
Total Pages : 502 pages
Book Rating : 4.44/5 ( download)

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Download or read book Handbook of Analysis of Oligonucleotides and Related Products written by Jose V. Bonilla and published by CRC Press. This book was released on 2011-02-23 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essen

Author : Jose V. Bonilla
Publisher : CRC Press
ISBN 13 : 1439819939
Total Pages : 514 pages
Book Rating : 4.37/5 ( download)

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Download or read book Handbook of Analysis of Oligonucleotides and Related Products written by Jose V. Bonilla and published by CRC Press. This book was released on 2011-02-23 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use. Topics discussed include: Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm) Approaches for the accurate determination of molar extinction coefficient of oligonucleotides Accurate determination of assay values Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals Strategies for determining the chemical stability of oligonucleotides The use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical development Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.

Author : Yashwant Vishnupant Pathak
Publisher : CRC Press
ISBN 13 : 143983699X
Total Pages : 346 pages
Book Rating : 4.96/5 ( download)

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Download or read book Handbook of Metallonutraceuticals written by Yashwant Vishnupant Pathak and published by CRC Press. This book was released on 2014-04-28 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nutritional and medicinal value of metals, such as zinc, calcium, and iron, has been known in traditional medicine for a long time. Other metals, such as silver and gold, may also have therapeutic and health benefits. Ancient medicines have long incorporated their use in the treatment of diseases, and they have also more recently been explored

Author : S.Z. Dziedzic
Publisher : Springer Science & Business Media
ISBN 13 : 1461521599
Total Pages : 288 pages
Book Rating : 4.94/5 ( download)

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Download or read book Handbook of Starch Hydrolysis Products and their Derivatives written by S.Z. Dziedzic and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Starch hydrolysis products are arguably the most versatile of all food sugar ingredients because they can be designed to meet many different nutritional and technological requirements. This book covers all aspects of starch production, from its hydrolysis to the analysis of the finished product. In addition, the most important derivatives of starch hydrolysis products are described and their applications in the food and, increasingly pharmaceutical industries are detailed. This book is essential reading for industrial food scientists and technologists, particularly those in processing and will be of interest to those involved in the formulation of pharmaceutical products. It is also a valuable reference source for food scientists and nutritionists in academic research institutes.

Author : Michael M. Wagner
Publisher : Elsevier
ISBN 13 : 0080459994
Total Pages : 621 pages
Book Rating : 4.98/5 ( download)

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Download or read book Handbook of Biosurveillance written by Michael M. Wagner and published by Elsevier. This book was released on 2011-04-28 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a coherent and comprehensive account of the theory and practice of real-time human disease outbreak detection, explicitly recognizing the revolution in practices of infection control and public health surveillance. Reviews the current mathematical, statistical, and computer science systems for early detection of disease outbreaks Provides extensive coverage of existing surveillance data Discusses experimental methods for data measurement and evaluation Addresses engineering and practical implementation of effective early detection systems Includes real case studies

Author : E. Goldberg
Publisher : Springer Science & Business Media
ISBN 13 : 9400915632
Total Pages : 745 pages
Book Rating : 4.33/5 ( download)

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Download or read book Handbook of Downstream Processing written by E. Goldberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last two decades have seen a phenomenal growth of the field of genetic or biochemical engineering and have witnessed the development and ultimately marketing of a variety of products-typically through the manipulation and growth of different types of microorganisms, followed by the recovery and purification of the associated products. The engineers and biotechnologists who are involved in the full-scale process design of such facilities must be familiar with the variety of unit operations and equipment and the applicable regulatory requirements. This book describes current commercial practice and will be useful to those engineers working in this field in the design, construction and operation of pharmaceutical and biotechnology plants. It will be of help to the chemical or pharmaceutical engineer who is developing a plant design and who faces issues such as: Should the process be batch or continuous or a combination of batch and continuous? How should the optimum process design be developed? Should one employ a new revolutionary separation which could be potentially difficult to validate or use accepted technology which involves less risk? Should the process be run with ingredients formulated from water for injection, deionized water, or even filtered tap water? Should any of the separations be run in cold rooms or in glycol jacketed lines to minimize microbial growth where sterilization is not possible? Should the process equipment and lines be designed to be sterilized in-place, cleaned-in-place, or should every piece be broken down, cleaned and autoclaved after every turn?

Author : Els. J. M. Van Damme
Publisher : John Wiley & Sons
ISBN 13 : 9780471964452
Total Pages : 478 pages
Book Rating : 4.5X/5 ( download)

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Download or read book Handbook of Plant Lectins written by Els. J. M. Van Damme and published by John Wiley & Sons. This book was released on 1998-03-06 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant lectins are extensively used as tools and as bioactiveproteins in different areas of biomedical and biological research.The Handbook of Plant Lectins provides a comprehensive yet conciseoverview of the biochemical properties, carbohydrate-bindingspecificity, biological activities and applications of most of thecurrently known plant lectins. This handbook consists of two majorsections: an introductory guide and a quick reference dictionary.Part I acquaints the newcomer to the lectin field with theessential information on lectins and their importance tobiomedicine: * what are lectins? * their carbohydrate-binding specificity * effects on nutrition and immunology * use in histochemistry * application as therapeutic agents Part II lists approximately 200 lectin entries in alphabeticalorder. Each entry deals with the lectin(s) of a particular plantand provides, (where known), details of: * isolation and characterisation; * sugar binding specificity; * biological activities; * applications; * commercial availability; and, * a bibliography. Useful summary tables list lectins according to their specificity,thereby allowing the user to choose the best lectin for theirapplication. A list of suppliers is also provided. Handbook ofPlant Lectins will be of interest to biologists and biomedicalresearchers studying cell biology, cancer research, nutrition,immunology, pathology and physiology.

Author : David Elder
Publisher :
ISBN 13 : 9781906799144
Total Pages : 350 pages
Book Rating : 4.48/5 ( download)

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Download or read book Analysis of Oligonucleotides and Their Related Substances written by David Elder and published by . This book was released on 2012-07 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title provides a comprehensive overview of the analytical challenges inherent in the testing and release of oligonucleotides.

Author : Satoshi Obika
Publisher : Springer
ISBN 13 : 981131912X
Total Pages : 284 pages
Book Rating : 4.29/5 ( download)

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Download or read book Synthesis of Therapeutic Oligonucleotides written by Satoshi Obika and published by Springer. This book was released on 2018-12-08 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research.

Author : George Okafo
Publisher :
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.41/5 ( download)

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Download or read book Analysis of Oligonucleotides and Their Related Substances written by George Okafo and published by . This book was released on 2013 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: