Grappling With The Multifaceted World Of The Dna Damage Response

Author : Antonio Porro
Publisher : Frontiers Media SA
ISBN 13 : 2889450570
Total Pages : 308 pages
Book Rating : 4.72/5 ( download)

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Download or read book Grappling with the Multifaceted World of the DNA Damage Response written by Antonio Porro and published by Frontiers Media SA. This book was released on 2017-01-10 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.63/5 ( download)

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Download or read book Grappling with the Multifaceted World of the DNA Damage Response written by and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.

Author : United Nations
Publisher : United Nations
ISBN 13 : 9290687894
Total Pages : 492 pages
Book Rating : 4.94/5 ( download)

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Download or read book World Migration Report 2020 written by United Nations and published by United Nations. This book was released on 2019-11-27 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 2000, IOM has been producing world migration reports. The World Migration Report 2020, the tenth in the world migration report series, has been produced to contribute to increased understanding of migration throughout the world. This new edition presents key data and information on migration as well as thematic chapters on highly topical migration issues, and is structured to focus on two key contributions for readers: Part I: key information on migration and migrants (including migration-related statistics); and Part II: balanced, evidence-based analysis of complex and emerging migration issues.

Author : National Intelligence Council
Publisher : Cosimo Reports
ISBN 13 : 9781646797721
Total Pages : 0 pages
Book Rating : 4.28/5 ( download)

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Download or read book Global Trends 2030 written by National Intelligence Council and published by Cosimo Reports. This book was released on 2018-02-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important report, Global Trends 2030-Alternative Worlds, released in 2012 by the U.S. National Intelligence Council, describes megatrends and potential game changers for the next decades. Among the megatrends, it analyzes: - increased individual empowerment - the diffusion of power among states and the ascent of a networked multi-polar world - a world's population growing to 8.3 billion people, of which sixty percent will live in urbanized areas, and surging cross-border migration - expanding demand for food, water, and energy It furthermore describes potential game changers, including: - a global economy that could thrive or collapse - increased global insecurity due to regional instability in the Middle East and South Asia - new technologies that could solve the problems caused by the megatrends - the possibility, but by no means the certainty, that the U.S. with new partners will reinvent the international system Students of trends, forward-looking entrepreneurs, academics, journalists and anyone eager for a glimpse into the next decades will find this essential reading.

Author : United Nations Department of Economic and Social Affairs
Publisher : United Nations
ISBN 13 : 9210548434
Total Pages : 250 pages
Book Rating : 4.34/5 ( download)

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Download or read book State of the World's Indigenous Peoples written by United Nations Department of Economic and Social Affairs and published by United Nations. This book was released on 2011-05-09 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: While indigenous peoples make up around 370 million of the world’s population – some 5 per cent – they constitute around one-third of the world’s 900 million extremely poor rural people. Every day, indigenous communities all over the world face issues of violence and brutality. Indigenous peoples are stewards of some of the most biologically diverse areas of the globe, and their biological and cultural wealth has allowed indigenous peoples to gather a wealth of traditional knowledge which is of immense value to all humankind. The publication discusses many of the issues addressed by the Declaration on the Rights of Indigenous Peoples and is a cooperative effort of independent experts working with the Secretariat of the Permanent Forum on Indigenous Issues. It covers poverty and well-being, culture, environment, contemporary education, health, human rights, and includes a chapter on emerging issues.

Author : Edgar H. Schein
Publisher : John Wiley & Sons
ISBN 13 : 047064057X
Total Pages : 466 pages
Book Rating : 4.79/5 ( download)

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Download or read book Organizational Culture and Leadership written by Edgar H. Schein and published by John Wiley & Sons. This book was released on 2010-07-16 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regarded as one of the most influential management books of all time, this fourth edition of Leadership and Organizational Culture transforms the abstract concept of culture into a tool that can be used to better shape the dynamics of organization and change. This updated edition focuses on today's business realities. Edgar Schein draws on a wide range of contemporary research to redefine culture and demonstrate the crucial role leaders play in successfully applying the principles of culture to achieve their organizational goals.

Author : Claudio Milano
Publisher : CABI
ISBN 13 : 1786399822
Total Pages : 265 pages
Book Rating : 4.23/5 ( download)

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Download or read book Overtourism written by Claudio Milano and published by CABI. This book was released on 2019-06-07 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the evolution of the phenomenon and explores the genesis of overtourism and the system dynamics underlining it. The 'overtourism' phenomenon is defined as the excessive growth of visitors leading to overcrowding and the consequential suffering of residents, due to temporary and often seasonal tourism peaks, that lead to permanent changes in lifestyles, amenities and well- being. Enormous tensions in overtourism affected destinations have driven the intensification of policy making and scholarly attention toward seeking antidotes to an issue that is considered paradoxical and problematic. Moving beyond the 'top 10 things you can do about overtourism', this book examines the evolution of the phenomenon and explores the genesis of overtourism as well as the system dynamics underpinning it. With a rigorous scientific approach, the book uses systems-thinking and contemporary paradigms around sustainable development, resilience planning and degrowth; while considering global economic, socio-political, environmental discourses. Researchers, analysts, policy makers and industry stakeholders working within tourism as well as those within the private sector, community groups, civil society groups and NGOs will find this book an essential source of information.

Author : National Intelligence Council (U.S.)
Publisher : U.S. Government Printing Office
ISBN 13 : 9780160915437
Total Pages : 166 pages
Book Rating : 4.30/5 ( download)

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Download or read book Global Trends 2030 written by National Intelligence Council (U.S.) and published by U.S. Government Printing Office. This book was released on 2012 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report is intended to stimulate thinking about the rapid and vast geopolitical changes characterizing the world today and possible global trajectories over the next 15 years. As with the NIC's previous Global Trends reports, we do not seek to predict the future, which would be an impossible feat, but instead provide a framework for thinking about possible futures and their implications. In-depth research, detailed modeling and a variety of analytical tools drawn from public, private and academic sources were employed in the production of Global Trends 2030. NIC leadership engaged with experts in nearly 20 countries, from think tanks, banks, government offices and business groups, to solicit reviews of the report.

Author : National Intelligence Council and Office
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781543054705
Total Pages : 80 pages
Book Rating : 4.06/5 ( download)

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Download or read book Global Trends written by National Intelligence Council and Office and published by Createspace Independent Publishing Platform. This book was released on 2017-02-17 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition of Global Trends revolves around a core argument about how the changing nature of power is increasing stress both within countries and between countries, and bearing on vexing transnational issues. The main section lays out the key trends, explores their implications, and offers up three scenarios to help readers imagine how different choices and developments could play out in very different ways over the next several decades. Two annexes lay out more detail. The first lays out five-year forecasts for each region of the world. The second provides more context on the key global trends in train.

Author : Alondra Nelson
Publisher : Beacon Press
ISBN 13 : 0807027189
Total Pages : 218 pages
Book Rating : 4.89/5 ( download)

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Download or read book The Social Life of DNA written by Alondra Nelson and published by Beacon Press. This book was released on 2016-09-20 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: The unexpected story of how genetic testing is affecting race in America We know DNA is a master key that unlocks medical and forensic secrets, but its genealogical life is both revelatory and endlessly fascinating. Tracing genealogy is now the second-most popular hobby amongst Americans, as well as the second-most visited online category. This billion-dollar industry has spawned popular television shows, websites, and Internet communities, and a booming heritage tourism circuit. The tsunami of interest in genetic ancestry tracing from the African American community has been especially overwhelming. In The Social Life of DNA, Alondra Nelson takes us on an unprecedented journey into how the double helix has wound its way into the heart of the most urgent contemporary social issues around race. For over a decade, Nelson has deeply studied this phenomenon. Artfully weaving together keenly observed interactions with root-seekers alongside illuminating historical details and revealing personal narrative, she shows that genetic genealogy is a new tool for addressing old and enduring issues. In The Social Life of DNA, she explains how these cutting-edge DNA-based techniques are being used in myriad ways, including grappling with the unfinished business of slavery: to foster reconciliation, to establish ties with African ancestral homelands, to rethink and sometimes alter citizenship, and to make legal claims for slavery reparations specifically based on ancestry. Nelson incisively shows that DNA is a portal to the past that yields insight for the present and future, shining a light on social traumas and historical injustices that still resonate today. Science can be a crucial ally to activism to spur social change and transform twenty-first-century racial politics. But Nelson warns her readers to be discerning: for the social repair we seek can’t be found in even the most sophisticated science. Engrossing and highly original, The Social Life of DNA is a must-read for anyone interested in race, science, history and how our reckoning with the past may help us to chart a more just course for tomorrow.