Glia And Inflammation In Neurodegenerative Disease

Author : M. A. Yenari
Publisher : Nova Science Publishers
ISBN 13 :
Total Pages : 290 pages
Book Rating : 4.08/5 ( download)

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Download or read book Glia and Inflammation in Neurodegenerative Disease written by M. A. Yenari and published by Nova Science Publishers. This book was released on 2006 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain has long been considered an immune privileged organ, meaning that inflammatory cells are excluded due to a relatively impenetrable blood brain barrier (BBB). However, this is not to say that the central nervous system is incapable of eliciting immune responses, as resident inflammatory cells exist within the brain parenchyma. Microglia have long been thought to be the brain's resident immune cell with myeloid lineage similar to monocytes and macrophages. In this volume, the authors review the current state of knowledge with regard to immune responses and cell-cell interactions as they pertain to a variety of neurodegenerative diseases. The changing role of inflammation with development is considered. They also present a summary of the various therapeutic strategies employed both in the laboratory and at the clinical level.

Author : Andras Lakatos
Publisher : Frontiers Media SA
ISBN 13 : 2889718409
Total Pages : 88 pages
Book Rating : 4.05/5 ( download)

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Download or read book Primary Glial and Immune Cell Pathology in Neurodegenerative Diseases written by Andras Lakatos and published by Frontiers Media SA. This book was released on 2021-12-21 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Carlos Barcia
Publisher : Frontiers Media SA
ISBN 13 : 2889198359
Total Pages : 226 pages
Book Rating : 4.51/5 ( download)

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Download or read book Glial Cells: Managers of Neuro-immunity written by Carlos Barcia and published by Frontiers Media SA. This book was released on 2016-05-30 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune responses within the brain are still scarcely explored. Nerve tissue damage is accompanied by the activation of glial cells, primarily microglia and astroglia, and such activation is responsible for the release of cytokines and chemokines that maintain the local inflammatory response and actively recruit lymphocytes and monocytes to the damaged areas. Theoretically, these responses are designed to repair the brain damage. However, alterations, or a chronic perpetuation of these responses may underlie a number of neuro-pathologies. It is thought that each inflammatory scenario within the brain have a specific biochemical footprint characterized by the release of determined cytokines, chemokines and growing factors able to define particular immunological responses. Alongside, glial cells transform their cell body, become larger and develop higher number of branches adopting an active morphological phenotype. These changes are related with the search of interactions with other cells, such as bystander resident cells of the brain parenchyma, but also cells homing from the blood stream. In this process, microglia and astrocytes communicates with other cells by the formation of specific intercellular connections that are still poorly understood. These interactions are complex and entail the arrangement of cytoskeletal compounds, secretory and phagocytic domains. In this particular crosstalk there is a two-way communication in which glial cells and target cells come together establishing interfaces with specific information exchange. This way, glial cells orchestrate the particular response recruiting cellular subsets within the central nervous system and organizing the resolution of the brain damage. In this Frontiers Research Topic, we compile a selection of articles unfolding diverse aspects of glial-derived inflammation, focused on neurodegenerative diseases and other nervous system disorders, with special emphasis on microglia/macrophages as leading actors managing neuro-immunity.

Author : Tania Spohr
Publisher : BoD – Books on Demand
ISBN 13 : 1789852536
Total Pages : 164 pages
Book Rating : 4.30/5 ( download)

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Download or read book Glia in Health and Disease written by Tania Spohr and published by BoD – Books on Demand. This book was released on 2020-05-20 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book will highlight the role played by glial cells in the central and peripheral nervous systems in both healthy and unhealthy individuals. Among all processes involved, we will discuss the importance of the enteric nervous system in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions such as metabolic syndrome. We will also look at the relevance of astrocytes during synaptic transmission and the regulation of plasticity by releasing gliotransmitters. Ultimately, we will highlight the influence of astrocytes during the development of a number of neurodegenerative diseases, such as multiple sclerosis and Alzheimer’s disease, focusing on how the serum levels of the astrocytic protein S100B can be used as a biomarker for clinical decisions.

Author : Yu Tang
Publisher : Frontiers Media SA
ISBN 13 : 2889634108
Total Pages : 202 pages
Book Rating : 4.01/5 ( download)

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Download or read book Linking Neuroinflammation and Glial Phenotypic Changes in Neurological Diseases written by Yu Tang and published by Frontiers Media SA. This book was released on 2020-01-15 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Tuan Leng Tay
Publisher : Frontiers Media SA
ISBN 13 : 2889760707
Total Pages : 259 pages
Book Rating : 4.01/5 ( download)

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Download or read book Understanding the Roles of Glia and Circulating Leukocytes in Neurodegenerative Diseases written by Tuan Leng Tay and published by Frontiers Media SA. This book was released on 2022-05-03 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Akio Suzumura
Publisher : Springer Science & Business Media
ISBN 13 : 1461483131
Total Pages : 192 pages
Book Rating : 4.37/5 ( download)

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Download or read book Neuron-Glia Interaction in Neuroinflammation written by Akio Suzumura and published by Springer Science & Business Media. This book was released on 2013-09-13 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accumulation on glia is an active pathological element in many neurological disorders. Gliosis produces neuroinflammation through both neurotrophic and inflammatory means, but the exact mechanism through which this happens remain unclear. It is suspected that damage to neurons activates the growth of glial cells. The proposed book focuses on the interaction between neurons and glia to help elucidate the pathophysiology of neuroinflammation in neurological disorders.​

Author : Marie-Ève Tremblay
Publisher : Springer
ISBN 13 : 1493914294
Total Pages : 490 pages
Book Rating : 4.96/5 ( download)

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Download or read book Microglia in Health and Disease written by Marie-Ève Tremblay and published by Springer. This book was released on 2014-09-22 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.

Author : Rommy von Bernhardi
Publisher : Springer
ISBN 13 : 3319407643
Total Pages : 349 pages
Book Rating : 4.47/5 ( download)

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Download or read book Glial Cells in Health and Disease of the CNS written by Rommy von Bernhardi and published by Springer. This book was released on 2016-10-06 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely overview covering the three major types of glial cells in the central nervous system - astrocytes, microglia, and oligodendrocytes. New findings on glia biology are overturning a century of conventional thinking about how the brain operates and are expanding our knowledge about information processing in the brain. The book will present recent research findings on the role of glial cells in both healthy function and disease. It will comprehensively cover a broad spectrum of topics while remaining compact in size.

Author : Beatriz G. Perez-Nievas
Publisher : Frontiers Media SA
ISBN 13 : 2889457648
Total Pages : 128 pages
Book Rating : 4.49/5 ( download)

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Download or read book The Role of Glia in Alzheimer's Disease written by Beatriz G. Perez-Nievas and published by Frontiers Media SA. This book was released on 2019-03-20 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: We believe that the role of glia is the next frontier to be explored in Alzheimer’s disease research. This eBook is an update on both the current knowledge of astrocytes and microglia involvement in Alzheimer’s disease pathophysiology, and some of the techniques available to study them.