Genomics Of Immunoregulation And Inflammatory Responses In The Tumor Microenvironment

Author : Lan Zhao
Publisher : Frontiers Media SA
ISBN 13 : 283251748X
Total Pages : 416 pages
Book Rating : 4.82/5 ( download)

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Download or read book Genomics of immunoregulation and inflammatory responses in the tumor microenvironment written by Lan Zhao and published by Frontiers Media SA. This book was released on 2023-03-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Apostolos Zaravinos
Publisher : Frontiers Media SA
ISBN 13 : 2832527124
Total Pages : 218 pages
Book Rating : 4.22/5 ( download)

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Download or read book Tumor Microenvironment, Inflammation, and Resistance to Immunotherapies written by Apostolos Zaravinos and published by Frontiers Media SA. This book was released on 2023-06-29 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Xi Cheng
Publisher : Frontiers Media SA
ISBN 13 : 2832540821
Total Pages : 213 pages
Book Rating : 4.24/5 ( download)

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Download or read book Community Series in the Role of Angiogenesis and Immune Response in Tumor Microenvironment of Solid Tumor, volume II written by Xi Cheng and published by Frontiers Media SA. This book was released on 2023-12-13 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is the second volume of the “Community Series in the Role of Angiogenesis and Immune Response in Tumor Microenvironment of Solid Tumor". Please Volume I here. The microenvironment of tumors is consisted of the tumor stroma, proliferating tumor cells, infiltrating inflammatory cells, blood vessels, and various associated tissue cells. The pre-metastatic niche (PRN) is described as supportive and receptive, which undergoes cellular and molecular changes to form the fertile “soil” or metastatic-designated sites for metastatic tumor cell “seed” colonization. Thus, the PRN supports promoting tumor metastasis and tumor settlement in distant organs. The infiltration of the immune cells and the formation of blood vessels from the pre-metastatic sites are critical for the tumor microenvironment. Typically, the angiogenic factor is strongly associated with the inflammatory response during the development of tumors. Additionally, the immunoediting processes are essentially devoted to promoting angiogenesis and modulating the innate and specific immune responses.

Author : Macfarlane Burnet
Publisher : Elsevier
ISBN 13 : 1483159221
Total Pages : 289 pages
Book Rating : 4.25/5 ( download)

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Download or read book Immunological Surveillance written by Macfarlane Burnet and published by Elsevier. This book was released on 2014-05-17 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Surveillance

Author : Rudolf A. Raff
Publisher : University of Chicago Press
ISBN 13 : 022625657X
Total Pages : 545 pages
Book Rating : 4.73/5 ( download)

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Download or read book The Shape of Life written by Rudolf A. Raff and published by University of Chicago Press. This book was released on 2012-12-14 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rudolf Raff is recognized as a pioneer in evolutionary developmental biology. In their 1983 book, Embryos, Genes, and Evolution, Raff and co-author Thomas Kaufman proposed a synthesis of developmental and evolutionary biology. In The Shape of Life, Raff analyzes the rise of this new experimental discipline and lays out new research questions, hypotheses, and approaches to guide its development. Raff uses the evolution of animal body plans to exemplify the interplay between developmental mechanisms and evolutionary patterns. Animal body plans emerged half a billion years ago. Evolution within these body plans during this span of time has resulted in the tremendous diversity of living animal forms. Raff argues for an integrated approach to the study of the intertwined roles of development and evolution involving phylogenetic, comparative, and functional biology. This new synthesis will interest not only scientists working in these areas, but also paleontologists, zoologists, morphologists, molecular biologists, and geneticists.

Author : Tim F. Greten
Publisher : Springer
ISBN 13 : 9783319879116
Total Pages : 0 pages
Book Rating : 4.11/5 ( download)

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Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Author : Xiangqian Guo
Publisher : Frontiers Media SA
ISBN 13 : 2889767973
Total Pages : 192 pages
Book Rating : 4.77/5 ( download)

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Download or read book Tumor-Associated Antigens and Their Autoantibodies: From Discovering to Clinical Utilization written by Xiangqian Guo and published by Frontiers Media SA. This book was released on 2022-08-18 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Maciej Henneberg
Publisher : Bentham Science Publishers
ISBN 13 : 1681082357
Total Pages : 192 pages
Book Rating : 4.56/5 ( download)

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Download or read book The Dynamic Human written by Maciej Henneberg and published by Bentham Science Publishers. This book was released on 2016-03-24 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The natural world can be viewed as a continuously changing complex system comprising variable units that do not conform to any stable plan. Within this framework, human evolution is not the story of the past that created Homo sapiens and then handed this account over to written history. It is the ongoing process that shapes us now and will shape us in the future, body and mind. We must understand it in order to survive and be able to direct it to our advantage. The Dynamic Human presents a general theory of how humans function as a multi-individual system embedded in the natural world. The authors employ a unified approach of systems theory to outline forces that direct ongoing human evolution and produce its outcomes in terms of the past, present and future. Readers will find a perspective on the human place in nature, through a brief account of the past human evolution over 10 million years ago, a discussion of the earliest appearance of humans some 2 million years ago, and a description of the mechanisms of the changes in the gene pool of humans from generation-to-generation. Understanding the forces involved in these mechanisms (physical and mental growth and development) may allow us to understand world better. The Dynamic Human presents a simplified perspective on human evolution for all readers interested in a discourse on the origins, nature and future of human beings.

Author : Nicola Fabris
Publisher : Springer Science & Business Media
ISBN 13 : 1468445472
Total Pages : 473 pages
Book Rating : 4.73/5 ( download)

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Download or read book Immunoregulation written by Nicola Fabris and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunoregulation is one of the areas which has witnessed the most explosive advances of immunology during the past decade. It is in this area that the current view of the immune system has arisen and developed. There is indeed little doubt that immune reactions are primarily determined by messages which are genera ted within the immune system and passed among different types of immunologie cells. This cell communication not only determines the type, intensity and duration of the response after perturbation of the immune system by exogenous antigens, but it is also essential for preventing autoimmune reactions and their clinical conse quences. In order to assure aperfect balance within the enormous com plexity of the immune system, it is not surprising that multiple self-regulatory mechanisms are organized at different levels, such as antibody feedback, idiotypic-anti-idiotypic responses, suppres sor and helper T cells, lymphokine signals and genetic require ments. A nu mb er of observations in recent years have, however, demonstrated that consistent contributions to the immunological homeostasis are given also by signals generated outside of the immune system, namely,in the central and autonomous nervous system as weIl as in the endocrine apparatus. Furthermore, the interactions between the immune system and the other body homestatic mechanisms seem to be bidirectional: if immunological cells may be targets of neuroendocrinological factors, immunological products seem in turn to contribute to the neuro endocrine homeostasis.

Author : Manzoor M. Khan
Publisher : Springer Science & Business Media
ISBN 13 : 0387779760
Total Pages : 275 pages
Book Rating : 4.68/5 ( download)

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Download or read book Immunopharmacology written by Manzoor M. Khan and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.