Genomics And Pharmacogenomics In Anticancer Drug Development And Clinical Response

Author : Federico Innocenti
Publisher : Springer Science & Business Media
ISBN 13 : 1603270884
Total Pages : 379 pages
Book Rating : 4.85/5 ( download)

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Download or read book Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response written by Federico Innocenti and published by Springer Science & Business Media. This book was released on 2008-10-30 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer - tients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients, the tumor DNA information should be in- grated with the available data on polymorphic drug-metabolizing enzyme and tra- porter genes mediating the exposure of patients to active drugs and/or their active metabolites. The chapters of this book clearly show how DNA information from both the host (germline) and the tumor should be taken into account for rational selection of drug therapies in cancer patients, an aspect that received little attention, despite its importance. The availability of new molecular approaches to the selection of drug therapy is an emerging need, because the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many treated patients do not experience signi?cant bene?ts from the treatment, while they often experience moderate to severe toxicities. In addition, the development and clinical use of novel molecularly targeted agents (alone or in combination with classical cytotoxic therapy) requires the und- standing of the molecular features of the tumors and the identi?cation of tumor markers of response.

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309462630
Total Pages : 145 pages
Book Rating : 4.31/5 ( download)

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Download or read book Enabling Precision Medicine written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-11-17 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine. On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development. Participants examined successes, challenges, and possible best practices for effectively using genetic information in the design and implementation of clinical trials to support the development of precision medicines, including exploring the potential advantages and disadvantages of such trials across a variety of disease areas. This publication summarizes the presentations and discussions from the workshop.

Author : Dimitri Semizarov
Publisher : John Wiley & Sons
ISBN 13 : 0470409762
Total Pages : 496 pages
Book Rating : 4.63/5 ( download)

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Download or read book Genomics in Drug Discovery and Development written by Dimitri Semizarov and published by John Wiley & Sons. This book was released on 2008-11-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.

Author : Yui-Wing Francis Lam
Publisher : Academic Press
ISBN 13 : 0123983037
Total Pages : 515 pages
Book Rating : 4.39/5 ( download)

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Download or read book Pharmacogenomics written by Yui-Wing Francis Lam and published by Academic Press. This book was released on 2013-02-12 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. Multi-contributed book and chapters are written by contributors who are experts in their field Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Author : Yui-Wing Francis Lam
Publisher : Academic Press
ISBN 13 : 0128126272
Total Pages : 442 pages
Book Rating : 4.71/5 ( download)

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Download or read book Pharmacogenomics written by Yui-Wing Francis Lam and published by Academic Press. This book was released on 2018-11-27 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition, provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as pharmacogenomic data technologies, clinical testing strategies, cost-effectiveness, and pharmacogenomic education and practice guidelines. The importance of ethnicity is also discussed, which highlights phar,acogenomic diversity across Latin American populations. With chapters written by interdisciplinary experts and insights into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation. Provides viewpoints that focus on the scientific and translational challenges and opportunities associated with advancing the field of pharmacogenomics Highlights progress in both the research and clinical areas of pharmacogenomics, as well as relevant implementation experience, challenges, and perspectives on direct-to-consumer genetic testing Includes, where applicable, discussion points, review questions, and cases for self-assessment purposes and to facilitate in-depth discussion

Author : Qing Yan
Publisher : Springer Nature
ISBN 13 : 107162573X
Total Pages : 618 pages
Book Rating : 4.36/5 ( download)

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Download or read book Pharmacogenomics in Drug Discovery and Development written by Qing Yan and published by Springer Nature. This book was released on 2022-09-06 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

Author :
Publisher : Elsevier
ISBN 13 : 9780080471013
Total Pages : 432 pages
Book Rating : 4.13/5 ( download)

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Download or read book Advances in Cancer Research written by and published by Elsevier. This book was released on 2011-07-29 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume stands as the first ever thematic volume in the series, focusing on the topic of genomics in cancer drug development. The chapters included in this book represent the cutting-edge information in the field and span such topics as Mass Spectrometry: Uncovering the Cancer Proteome for Diagnostics; Biomarker Discovery in Epithelial Ovarian Cancer by Genomic Approaches; The Application of siRNA Technology to Cancer Biology Discovery; Ribozyme Technology for Cancer Gene Target Identification and Validation; Cancer Cell-Based Genomic and Small Molecule Screens; Tumour Antigens as Surrogate Markers and Targets for Therapy and Vaccines; Practices and Pitfalls of Mouse Cancer Models in Drug Discovery; Biomarker Assay Translation from Discovery to Clinical Studies in Cancer Drug Development – Quantification of Emerging Protein Biomarkers; Molecular Optical Imaging of Therapeutic Targets of Cancer; Cancer Drug Approval in the United States, Europe and Japan.

Author : Linda P. Barnes
Publisher : Nova Publishers
ISBN 13 : 9781600210563
Total Pages : 636 pages
Book Rating : 4.62/5 ( download)

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Download or read book New Research on Pharmacogenetics written by Linda P. Barnes and published by Nova Publishers. This book was released on 2007 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: The terms pharmacogenomics and pharmacogenetics tend to be used interchangeably, and a precise, consensus definition of either remains elusive. Pharmacogenetics is generally regarded as the study of genetic variation that gives rise to differing response to drugs, while pharmacogenomics is the broader application of genomic technologies to new drug discovery and further characterization of older drugs. Pharmacogenetics considers one or at most a few genes of interest, while pharmacogenomics considers the entire genome. Much of current clinical interest is at the level of pharmacogenetics, involving variation in genes involved in drug metabolism with a particular emphasis on improving drug safety. This new book presents leading-edge research in this dynamic field.

Author : Weimin Cai
Publisher : Springer Nature
ISBN 13 : 9811538956
Total Pages : 290 pages
Book Rating : 4.57/5 ( download)

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Download or read book Pharmacogenomics in Precision Medicine written by Weimin Cai and published by Springer Nature. This book was released on 2020-06-12 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Author : Showkat Ahmad Ganie
Publisher : Elsevier
ISBN 13 : 044315337X
Total Pages : 392 pages
Book Rating : 4.72/5 ( download)

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Download or read book Pharmacogenomics written by Showkat Ahmad Ganie and published by Elsevier. This book was released on 2023-06-13 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics: From Discovery to Clinical Implementation is a complete reference aimed at building a solid foundation of the key concepts in this fast-moving knowledge area. The editors lined up a group of worldwide experts to contribute to the book. Following a consistent chapter structure, the authors cover the foundational aspects of pharmacogenomics in the first four chapters of the book that include basic concepts, drug metabolism, drug discovery and development, and testing. The second part of the book is dedicated to detailed studies of key health conditions and the potential therapeutic applications of pharmacogenomics. Diseases covered include diabetes, cardiovascular diseases, psychiatric disease, cancer, pulmonary and respiratory diseases, viral diseases, gastroenterology, autoimmune diseases, immunosuppressants, and, finally, an overview of computational resources. Pharmacogenomics: From Discovery to Clinical Implementation is the perfect resource for pharmaceutical science graduate students to learn the key concepts of the area. Researchers and graduate students in the related fields of Genetics, pharmacoepidemiology, molecular biology, and medicinal chemistry will also benefit of the structured approach of the book. Provides an in-depth review of pharmacogenomics and its role in drug discovery/metabolism and its clinical impacts Describes the practice of pharmacogenomics in the treatment of diabetes, cancers, cardiovascular diseases, psychiatric disorders, pulmonary diseases, infectious, gastroenterology, and autoimmune diseases Uses a consistent chapter structure to support understanding of the fundamental concepts in the area