Genetic Control Of Malaria And Dengue

Author : Zach N. Adelman
Publisher : Academic Press
ISBN 13 : 0128004053
Total Pages : 486 pages
Book Rating : 4.50/5 ( download)

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Download or read book Genetic Control of Malaria and Dengue written by Zach N. Adelman and published by Academic Press. This book was released on 2015-10-15 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission Provides a summary of the concepts of both population suppression and population replacement Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309377595
Total Pages : 397 pages
Book Rating : 4.91/5 ( download)

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Download or read book Global Health Impacts of Vector-Borne Diseases written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-10-21 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathogens transmitted among humans, animals, or plants by insects and arthropod vectors have been responsible for significant morbidity and mortality throughout recorded history. Such vector-borne diseases â€" including malaria, dengue, yellow fever, and plague â€" together accounted for more human disease and death in the 17th through early 20th centuries than all other causes combined. Over the past three decades, previously controlled vector-borne diseases have resurged or reemerged in new geographic locations, and several newly identified pathogens and vectors have triggered disease outbreaks in plants and animals, including humans. Domestic and international capabilities to detect, identify, and effectively respond to vector-borne diseases are limited. Few vaccines have been developed against vector-borne pathogens. At the same time, drug resistance has developed in vector-borne pathogens while their vectors are increasingly resistant to insecticide controls. Furthermore, the ranks of scientists trained to conduct research in key fields including medical entomology, vector ecology, and tropical medicine have dwindled, threatening prospects for addressing vector-borne diseases now and in the future. In June 2007, as these circumstances became alarmingly apparent, the Forum on Microbial Threats hosted a workshop to explore the dynamic relationships among host, pathogen(s), vector(s), and ecosystems that characterize vector-borne diseases. Revisiting this topic in September 2014, the Forum organized a workshop to examine trends and patterns in the incidence and prevalence of vector-borne diseases in an increasingly interconnected and ecologically disturbed world, as well as recent developments to meet these dynamic threats. Participants examined the emergence and global movement of vector-borne diseases, research priorities for understanding their biology and ecology, and global preparedness for and progress toward their prevention, control, and mitigation. This report summarizes the presentations and discussions from the workshop.

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309437873
Total Pages : 231 pages
Book Rating : 4.75/5 ( download)

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Download or read book Gene Drives on the Horizon written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-08-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Author : Rebeca Carballar-Lejarazú
Publisher : CRC Press
ISBN 13 : 1000626008
Total Pages : 277 pages
Book Rating : 4.01/5 ( download)

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Download or read book Mosquito Gene Drives and the Malaria Eradication Agenda written by Rebeca Carballar-Lejarazú and published by CRC Press. This book was released on 2023-02-24 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is one of most serious infectious diseases today and has afflicted humankind for thousands of years. A significant number of people still die from this mosquito-borne disease, despite the use of various malaria prevention and control methods over hundreds of years and more than a century of coordinated global control efforts using modern tools, together with research into and development of new strategies for prevention, diagnosis, and disease treatment. Genetic approaches that focus on the vector mosquitoes to prevent malaria parasite transmission have been considered for many decades. Genetic control strategies received a significant boost with the successful development of gene drive systems, genetic methods for rapidly spreading beneficial genes and phenotypes through mosquito populations. This book reviews some concepts of gene drive systems and describes pioneering applications to control mosquito populations and prevent parasite transmission.

Author : Christophe Boete
Publisher : CRC Press
ISBN 13 : 149871286X
Total Pages : 174 pages
Book Rating : 4.66/5 ( download)

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Download or read book Genetically Modified Mosquitoes for Malaria Control written by Christophe Boete and published by CRC Press. This book was released on 2006-07-15 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite a century of research and attempts to control one of the deadliest foes of mankind, the malaria situation remains a major public health problem. Obviously biological explanations (the resistance of parasites and mosquitoes against available drugs and insecticides respectively) are often given, but they remain partial and incomplete. Indeed,

Author : Arnim von Gleich
Publisher : Springer Nature
ISBN 13 : 3030389340
Total Pages : 264 pages
Book Rating : 4.45/5 ( download)

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Download or read book Gene Drives at Tipping Points written by Arnim von Gleich and published by Springer Nature. This book was released on 2020-01-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book reports on a pilot project aiming at collecting information on the socio-ecological risks that could arise in the event of an uncontrolled spread of genetically engineered organisms into the environment. The researchers will, for instance, be taking a closer look at genetically engineered oilseed rape, genetically engineered olive flies as well as plants and animals with so-called gene drives. The book mainly adresses researchers.

Author : Brij Kishore Tyagi
Publisher :
ISBN 13 : 9789811629655
Total Pages : 0 pages
Book Rating : 4.5X/5 ( download)

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Download or read book Genetically Modified and Other Innovative Vector Control Technologies written by Brij Kishore Tyagi and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies. This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.

Author : Norbert Becker
Publisher : Springer Nature
ISBN 13 : 3030116239
Total Pages : 570 pages
Book Rating : 4.31/5 ( download)

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Download or read book Mosquitoes written by Norbert Becker and published by Springer Nature. This book was released on 2020-09-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Mosquitoes – Identification, Ecology and Control” presents a wealth of information on the bionomics, systematics, ecology, research techniques and control of both nuisance and disease vector mosquitoes. It provides practical guidance and important information in an easily readable style, suitable for anyone involved with, or interested in mosquitoes and their management. In this new edition, 102 European species including the most important invasive species and more than 100 globally important vector and nuisance species are described. Most of them, including all European species, are presented in the fully illustrated identification keys, followed by a detailed description of the morphology, biology, distribution and medical importance of each species, including over 700 detailed drawings. “Mosquitoes – Identification, Ecology and Control” includes: · systematics and biology · medical significance · research techniques · morphological characteristics used for identification of larvae and adults · illustrated identification keys for larval and adult mosquito genera · morphology, ecology, and distribution of the species identified in the keys · biological, genetic, physical and chemical control of mosquitoes “Mosquitoes – Identification, Ecology and Control” is a valuable tool for vector ecologists, medical entomologists, students and all those involved with mosquito systematics, biology, ecology, and control world-wide. Society as a whole benefit from the implementation of carefully designed and sustainable programs for the management of mosquitoes, and the diseases they transmit. The third edition of this successful publication has been comprehensively updated and expanded, to provide the foundation of a more enlightened and informed approach to mosquito management.

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309177707
Total Pages : 350 pages
Book Rating : 4.02/5 ( download)

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Download or read book Vector-Borne Diseases written by Institute of Medicine and published by National Academies Press. This book was released on 2008-03-18 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vector-borne infectious diseases, such as malaria, dengue fever, yellow fever, and plague, cause a significant fraction of the global infectious disease burden; indeed, nearly half of the world's population is infected with at least one type of vector-borne pathogen (CIESIN, 2007; WHO, 2004a). Vector-borne plant and animal diseases, including several newly recognized pathogens, reduce agricultural productivity and disrupt ecosystems throughout the world. These diseases profoundly restrict socioeconomic status and development in countries with the highest rates of infection, many of which are located in the tropics and subtropics. Although this workshop summary provides an account of the individual presentations, it also reflects an important aspect of the Forum philosophy. The workshop functions as a dialogue among representatives from different sectors and allows them to present their beliefs about which areas may merit further attention. These proceedings summarize only the statements of participants in the workshop and are not intended to be an exhaustive exploration of the subject matter or a representation of consensus evaluation. Vector-Borne Diseases : Understanding the Environmental, Human Health, and Ecological Connections, Workshop Summary (Forum on Microbial Threats) summarizes this workshop.

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 9780309045278
Total Pages : 312 pages
Book Rating : 4.74/5 ( download)

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Download or read book Malaria written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.