Gaba In Autism And Related Disorders

Author : Dirk M. Dhossche
Publisher : Gulf Professional Publishing
ISBN 13 : 9780123668721
Total Pages : 528 pages
Book Rating : 4.27/5 ( download)

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Download or read book Gaba in Autism and Related Disorders written by Dirk M. Dhossche and published by Gulf Professional Publishing. This book was released on 2005-12-07 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gamma-aminobutyric acid (GABA) was discovered in the brain in 1950 by Eugene Roberts. GABA is now considered one of the most important neurotransmitters and developmental signals. Knowledge on the complexity of GABA function is increasing exponentially. This volume covers basic research on GABA in the developing brain as it may relate to onset of autism and related developmental disorders. The evidence that dysfunction of GABA and related molecules is associated with autism is limited but expanding and seems to converge. Pertinent data are reviewed in this book and new research avenues in the basic and clinical arenas are described. The topics are of imminent interest to basic and clinical researchers as well as interested clinicians. * Discusses the neuropathology of the GABA system in autism * Presents new findings on common genetic mechanisms in Rett syndrome, Angelman syndrome, and autism * Includes information on the shared genetic risk factors between autism and major mental disorders * Foreword by Eugene Roberts

Author : Michael Fitzgerald
Publisher : BoD – Books on Demand
ISBN 13 : 9535120379
Total Pages : 380 pages
Book Rating : 4.77/5 ( download)

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Download or read book Autism Spectrum Disorder written by Michael Fitzgerald and published by BoD – Books on Demand. This book was released on 2015-04-02 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism cross culturally. It also examines the issue of hyperandrogenism and evidence-based treatments of autism. In terms of assessment, it focuses on psychological and biological assessment including neurotransmitters systems, structural and functional brain imaging, coping strategies of parents, examines the intertwining of language impairment, specific language impairment and ASD, as well as implicit and spontaneous Theory of Mind reading in ASD. In terms of aetiology, it focuses on genetic factors, epigenetics, synaptic vesicles, toxicity during neurodevelopment, immune system and sex differences. It also examines the link between social cognitive anatomical and neurophysiologic biomarkers and candidate genes. This book will be relevant to all mental health professionals because autism occurs in all the different areas of psychiatry and professionals who will find it helpful will be psychiatrists, psychologists, social workers, nurses, teachers and all those working with persons with Autism including parents who nowadays are interested in knowing more and more, at a detailed level about their children or adults with autism.

Author : Joseph I. Tracy
Publisher : Oxford University Press, USA
ISBN 13 : 0199965242
Total Pages : 433 pages
Book Rating : 4.43/5 ( download)

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Download or read book Cognitive Plasticity in Neurologic Disorders written by Joseph I. Tracy and published by Oxford University Press, USA. This book was released on 2014-12-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.

Author : Gene J. Blatt
Publisher : Springer Science & Business Media
ISBN 13 : 144191272X
Total Pages : 300 pages
Book Rating : 4.25/5 ( download)

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Download or read book The Neurochemical Basis of Autism written by Gene J. Blatt and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: A perceived rise in autism worldwide has led to a dramatic increase in autism research. This is a uniquely interdisciplinary text that presents the latest findings regarding the physiological, neuropathological, neurochemical and clinical elements of autism.

Author : David Amaral
Publisher : Oxford University Press
ISBN 13 : 0199707472
Total Pages : 1456 pages
Book Rating : 4.78/5 ( download)

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Download or read book Autism Spectrum Disorders written by David Amaral and published by Oxford University Press. This book was released on 2011-05-01 with total page 1456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research. Approximately 1 in 150 children are diagnosed as autistic, so it is also an intense growth area in behavioral and educational treatments. Financial resources have begun to be raised for more comprehensive research and an increasing number of scientists are becoming involved in autism research. In many respects, autism has become a model for conducting translational research on a psychiatric disorder. This text provides a comprehensive summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders including major behavioral and cognitive syndromology, common co-morbid conditions, neuropathology, neuroimmunology, and other neurological correlates such as seizures, allergy and immunology, gastroenterology, infectious disease, and epidemiology. Edited by three leading researchers, this volume contains over 80 chapters and nine shorter commentaries by thought leaders in the field, making the book a virtual "who's who" of autism research. This carefully developed book is a comprehensive and authoritative reference for what we know in this area as well as a guidepost for the next several years in all areas of autism research.

Author : Manuel F. Casanova
Publisher : CRC Press
ISBN 13 : 9781498709811
Total Pages : 0 pages
Book Rating : 4.18/5 ( download)

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Download or read book Autism Imaging and Devices written by Manuel F. Casanova and published by CRC Press. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface -- Contributors -- 1 Present and future autism data science -- 2 Twin research in autism spectrum disorder -- 3 Neurodevelopment of autism: The first three years of life -- 4 Anatomy of autism -- 5 Neurobiology of imitation in autism -- 6 Neuroimaging biomarkers for autism spectrum disorder -- 7 Structural magnetic resonance imaging of autism spectrum disorder -- 8 Atypical hemispheric asymmetries in autism spectrum disorders -- 9 Corpus callosum and autism -- 10 Macrocephaly and megalencephaly in autism spectrum disorder -- 11 Imaging the striatum in autism spectrum disorder -- 12 GABA system dysfunction in autism and related disorders: From synapse to symptoms? -- 13 Imaging brain connectivity in autism spectrum disorder -- 14 Brain network organization in ASD: Evidence from functional and diffusion weighted MRI -- 15 Behavioral signal processing and autism: Learning from multimodal behavioral signals -- 16 Behavior Imaging®: Innovative technology to enable remote autism diagnosis -- 17 Behavior Imaging®: Resolving assessment challenges for autism spectrum disorder in pharmaceutical trials -- 18 Virtual reality with psychophysio logical monitoring as an approach to evaluate emotional reactivity, social skills, and joint attention in autism spectrum disorder -- 19 The impact of robots on children with autism spectrum disorder -- 20 Using an ecological systems approach to target technology development for autism research and beyond -- 21 Electrophysiology of error processing in individuals with autism spectrum disorder: A meta-analysis -- 22 Gamma abnormalities in autism spectrum disorders -- 23 Repetitive transcranial magnetic stimulation (rTMS) effects on evoked and induced gamma frequency EEG oscillations in autism spectrum disorder -- Index

Author : Detlev Boison
Publisher : Oxford University Press
ISBN 13 : 0199322295
Total Pages : 657 pages
Book Rating : 4.99/5 ( download)

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Download or read book Homeostatic Control of Brain Function written by Detlev Boison and published by Oxford University Press. This book was released on 2016 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

Author : Takao K. Hensch
Publisher : Springer Science & Business Media
ISBN 13 : 1461500397
Total Pages : 286 pages
Book Rating : 4.91/5 ( download)

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Download or read book Excitatory-Inhibitory Balance written by Takao K. Hensch and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new perspective on brain function depends upon an understanding of the interaction and integration of excitation and inhibition. A recent surge in research activity focused on inhibitory interneurons now makes a more balanced view possible. Technological advances such as improved imaging methods, visualized patch-clamp recording, multiplex single-cell PCR, and gene-targeted deletion or knock-in mice are some of the novel tools featured in this book. This book will provide an integrated view of neuron function, operating in a balanced regime of excitation and inhibition. It is a timely contribution emphasizing how this balance is established, maintained, and modified from the molecular to system levels. The broad spectrum of topics from molecular to cellular and system/computational neuroscience will appeal to a wide audience of advanced graduate students, post-docs, and faculty. Moreover, this book this book features active young researchers from around the world, who are currently educating the brain scientists of tomorrow.

Author : Mario Manto
Publisher : Springer
ISBN 13 : 9789400713321
Total Pages : 0 pages
Book Rating : 4.20/5 ( download)

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Download or read book Handbook of the Cerebellum and Cerebellar Disorders written by Mario Manto and published by Springer. This book was released on 2012-08-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.

Author : Andreas M. Grabrucker
Publisher :
ISBN 13 :
Total Pages : 117 pages
Book Rating : 4.89/5 ( download)

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Download or read book Autism Spectrum Disorders written by Andreas M. Grabrucker and published by . This book was released on 2021 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism spectrum disorders are developmental disorders. Individuals with autism spectrum disorders develop differently. These differences are usually present in social interaction, communication, and sensory processing, and become visible through a wide variety of behavioral responses that differ from individuals without autism spectrum disorders. Despite significant research efforts, the exact causes of autism spectrum disorders remain poorly understood; however, researchers have gained extensive insights into possible pathomechanisms, even at the molecular level of cells. Many diagnostic criteria have been developed, adapted, and improved. The eight chapters in this book highlight the current state-of-the-art in many areas of autism spectrum disorders. Chapter 1 provides an overview of the epidemiology of autism spectrum disorders and the current knowledge of the underlying pathogenic mechanisms. Chapter 2 summarizes the diagnostic criteria and procedures and highlights present and upcoming therapeutic strategies. Chapter 3 reviews the adverse events and trauma in people with autism spectrum disorders. Chapters 4 and 5 focus on atypical sensory processing, and Chapter 6 discusses the genetic overlap of autism spectrum disorders with other neuropsychiatric disorders such as attention deficit hyperactivity disorder (ADHD), depression, and schizophrenia. Chapter 7 focuses on the contribution of abnormalities in mitochondria, and chapter 8 discusses gut-brain interactions and a potential role for microbiota in autism spectrum disorders. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.