Functionalised Cardiovascular Stents

Author : Gerard Wall
Publisher : Woodhead Publishing
ISBN 13 : 0081004982
Total Pages : 368 pages
Book Rating : 4.82/5 ( download)

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Download or read book Functionalised Cardiovascular Stents written by Gerard Wall and published by Woodhead Publishing. This book was released on 2018-02-06 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis. This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo. Provides a specific focus on cardiovascular stents Includes a range of topics covering the fundamentals, surface modification and biofunctionalization Provides essential knowledge for researchers on advances in the field

Author : Romain Schieber
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.51/5 ( download)

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Download or read book Novel Functionalized and Patterned Surfaces for Cardiovascular Applications written by Romain Schieber and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Yoshinobu Onuma
Publisher : CRC Press
ISBN 13 : 1498779778
Total Pages : 533 pages
Book Rating : 4.77/5 ( download)

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Download or read book Bioresorbable Scaffolds written by Yoshinobu Onuma and published by CRC Press. This book was released on 2017-10-02 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the coronary bioresorbable scaffold, a new interventional treatment for coronary artery disease, differentiated from a permanent metallic stent. The book provides an overview of the technology including non-clinical studies and clinical evidences in order to help clinicians understand the appropriate application of the technology and the optimal techniques of implantation. It covers the basics of bioresorbable scaffolds; bench test results; preclinical studies; clinical evidences; and tips and tricks of implantation.

Author : Mike Driver
Publisher : Elsevier
ISBN 13 : 0857093673
Total Pages : 381 pages
Book Rating : 4.77/5 ( download)

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Download or read book Coatings for Biomedical Applications written by Mike Driver and published by Elsevier. This book was released on 2012-02-22 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biomaterials sector is rapidly expanding and significant advances have been made in the technology of biomedical coatings and materials, which provide a means to improve the wear of joints, change the biological interaction between implant and host and combine the properties of various materials to improve device performance. Coatings for biomedical applications provides an extensive review of coating types and surface modifications for biomedical applications. The first part of the book explores a range of coating types and their biomedical applications. Chapters look at hydrophilic, mineral and pyrolytic carbon coatings in and ex vivo orthopaedic applications and finally at surface modification and preparation techniques. Part two presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices. With its clear structure and comprehensive review of research, Coatings for biomedical applications is a valuable resource to researchers, scientists and engineers in the biomedical industry. It will also benefit anyone studying or working within the biomedical sector, particularly those specialising in biomedical coatings. Provides an extensive review of coating types and surface modifications for biomedical applications Chapters look at hydrophilic coatings for biomedical applications in and ex vivo, mineral coatings for orthopaedic applications, pyrolytic carbon coating and other commonly-used biomedical coatings Presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices

Author : Craig Bonsignore
Publisher :
ISBN 13 : 9781481080699
Total Pages : 94 pages
Book Rating : 4.95/5 ( download)

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Download or read book Open Stent Design written by Craig Bonsignore and published by . This book was released on 2012-11-23 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design and engineering of self expanding cardiovascular stents.

Author : Ashutosh Tiwari
Publisher : John Wiley & Sons
ISBN 13 : 1118773683
Total Pages : 421 pages
Book Rating : 4.80/5 ( download)

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Download or read book Advanced Healthcare Materials written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2014-05-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers

Author : Terence Gourlay
Publisher : Woodhead Publishing
ISBN 13 : 9780081014684
Total Pages : 0 pages
Book Rating : 4.86/5 ( download)

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Download or read book Biomaterials and Devices for the Circulatory System written by Terence Gourlay and published by Woodhead Publishing. This book was released on 2016-08-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease is one of the leading causes of death in the world today. Thanks to major advances in circulatory biomaterials and medical devices over the past few decades, many complications of this prevalent disease can be managed with great success for prolonged periods. Biomaterials and devices for the circulatory system reviews the latest developments in this important field and how they can be used to improve the success and safety in this industry. Part one discusses physiological responses to biomaterials with chapters on tissue response, blood interface and biocompatibility. Part two then reviews clinical applications including developments in valve technology, percutaneous valve replacement, bypass technologies and cardiovascular stents. Part three covers future developments in the field with topics such as nanomedicine, cardiac restoration therapy, biosensor technology in the treatment of cardiovascular disease and vascular tissue engineering. With its distinguished editors and international team of contributors Biomaterials and devices for the circulatory system is a vital reference for those concerned with bioengineering, medical devices and clinicians within this critical field.

Author : Jinlian Hu
Publisher : Smithers Rapra
ISBN 13 : 1909030333
Total Pages : 326 pages
Book Rating : 4.36/5 ( download)

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Download or read book Shape Memory Polymers written by Jinlian Hu and published by Smithers Rapra. This book was released on 2014-05-27 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shape-memory polymers (SMP) are a unique branch of the smart materials family which are capable of changing shape on-demand upon exposure to external stimulus. The discovery of SMP made a significant breakthrough in the developments of novel smart materials for a variety of engineering applications, superseded the traditional materials, and also influenced the current methods of product designing. This book provides the latest advanced information of on-going research domains of SMP. This will certainly enlighten the reader to the achievements and tremendous potentials of SMP. The basic fundamentals of SMP, including shape-memory mechanisms and mechanics are described. This will aid reader to become more familiar with SMP and the basic concepts, thus guiding them in undergoing independent research in the SMP field. The book also provides the reader with associated challenges and existing application problems of SMP. This could assist the reader to focus more on these issues and further exploit their knowledge to look for innovative solutions. Future outlooks of SMP research are discussed as well. This book should prove to be extremely useful for academics, R&D managers, researcher scientists, engineers, and all others related to the SMP research.

Author : Anil Kumar
Publisher : Springer Nature
ISBN 13 : 9811596786
Total Pages : 1134 pages
Book Rating : 4.80/5 ( download)

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Download or read book Recent Advances in Mechanical Engineering written by Anil Kumar and published by Springer Nature. This book was released on 2021-05-25 with total page 1134 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the select proceedings of the second International Conference on Recent Advances in Mechanical Engineering (RAME 2020). The topics covered include aerodynamics and fluid mechanics, automation, automotive engineering, composites, ceramics and polymers processing, computational mechanics, failure and fracture mechanics, friction, tribology and surface engineering, heating and ventilation, air conditioning system, industrial engineering, IC engines, turbomachinery and alternative fuels, machinability and formability of materials, mechanisms and machines, metrology and computer-aided inspection, micro- and nano-mechanics, modelling, simulation and optimization, product design and development, rapid manufacturing technologies and prototyping, solid mechanics and structural mechanics, thermodynamics and heat transfer, traditional and non-traditional machining processes, vibration and acoustics. The book also discusses various energy-efficient renewable and non-renewable resources and technologies, strategies and technologies for sustainable development and energy & environmental interaction. The book is a valuable reference for beginners, researchers, and professionals interested in sustainable construction and allied fields.

Author : Hesam Dadafarin
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.45/5 ( download)

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Download or read book Electrochemically-assisted Functionalization of a 316L Stainless Steel Surface with Fibronectin written by Hesam Dadafarin and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Cardiovascular disease (CVD) is reported to be the single largest cause of death in developed countries. Among different types of CVD, a common and prevalent disorder is atherosclerosis, which is characterized mostly by the formation of a plaque resulting in considerable narrowing (stenosis) and hardening of the arteries. Approximately one third of atherosclerosis patients are treated by angioplasty and stenting. However, all current stents offer low biocompatibility, which results in occurrence of in-stent thrombosis and restenosis in up to ca. 30% patients, and the need for further medical treatment. Various stent-surface modification approaches have been employed in order to minimize in-stent restenosis, but none of them has proven to give long-term satisfactory benefits. The aim of this work was to develop a new method for the stent surface modification, in an attempt to decrease the in-stent restenosis rate. The ultimate aim of the project was to functionalize 316L stainless steel, CoCr and NiTi surfaces with a chemically-bound extracellular matrix protein fibronectin (Fn), in order to control and mediate endothelial cell (EC) and smooth muscle cell (SMC) / surface (Fn) interactions. In this PhD project, a novel electrochemistry-based method for the immobilization of Fn on 316L stainless steel, CoCr and NiTi surface was developed. The method is based on the formation of a stable alkanethiol monolayer ("linker") on the alloy surface, which was further chemically modified to allow covalent attachment of Fn. Polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) revealed that the formed alkanethiol monolayer is relatively ordered and well-packed. X-ray photoelectron spectroscopy (XPS) demonstrated that monolayer is attached to the 316L stainless steel surface through the sulfur atom. It was further confirmed that the monolayer remained stable over a period of seven days of constant immersion in a corrosive phosphate buffered saline solution. Long-term electrochemical impedance spectroscopy experiments demonstrated that the formed monolayer also provided a diffusion barrier for aggressive / corrosive ions, yielding a high (ca. 94%) corrosion protection efficiency for 316L stainless steel. It was determined that the covalent attachment of Fn to the alkanethiol monolayer pre-formed on 316L stainless steel, CoCr and NiTi surfaces resulted in the formation of a very stable protein layer. PM-IRRAS indicated that the covalent attachment of Fn resulted in a change of the protein's secondary structure. Scanning electron microscopy (SEM) and energy dispersive X-Ray (EDX) analysis of Fn molecules immobilized on a surface of a commercial 316L stainless steel cardiovascular stent revealed that a relative homogenous spatial distribution of Fn was achieved and the molecule spacing was appropriate for cell adhesion.The effect of Fn immobilization on a 316L stainless steel surface on cell/surface behavior was further investigated by examining the interaction with platelets, ECs and SMCs. Lower platelet adhesion and aggregation was observed on Fn-modified surfaces, in comparison to the naked (unmodified) surface, which implies a lower thrombogenicity of the Fn-modified surface. It was shown that the presence of Fn on the surface significantly enhanced EC attachment, while no detectable improvement in SMC attachment was observed. Higher proliferation rate of both ECs and SMCs was achieved on the Fn-modified surface. The comparative study of EC and SMC attachment revealed that Fn-modified surfaces can selectively attract more ECs than SMCs. This indicates a higher biocompatibility of the Fn-modified surface for coronary stent applications." --