Frontiers In Dengue Virus Research

Author : Kathryn A. Hanley
Publisher :
ISBN 13 : 9781912530908
Total Pages : pages
Book Rating : 4.02/5 ( download)

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Download or read book Frontiers in Dengue Virus Research written by Kathryn A. Hanley and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together a panel of expert dengue virologists to produce a timely review of the rapidly expanding dengue research literature. In addition authors identify the most pressing questions that remain to be answered, thus providing a stimulus for future research. Topics include: evolutionary history, epidemiology, translation and processing of the viral polyprotein, viral replication, the role of the viral untranslated regions, pathogenesis, host response to DENV, development of animal models, DENV-mosquito interactions, dynamics of dengue virus transmission, emergence of DENV from.

Author : Qiangming Sun
Publisher : Frontiers Media SA
ISBN 13 : 2889660028
Total Pages : 127 pages
Book Rating : 4.25/5 ( download)

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Download or read book Research Advances in Dengue Virus written by Qiangming Sun and published by Frontiers Media SA. This book was released on 2020-09-14 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Alan L. Rothman
Publisher : Springer Science & Business Media
ISBN 13 : 3642022154
Total Pages : 173 pages
Book Rating : 4.59/5 ( download)

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Download or read book Dengue Virus written by Alan L. Rothman and published by Springer Science & Business Media. This book was released on 2009-10-03 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific research on dengue has a long and rich history. The literature has been touched by famous names in medicine- Benjamin Rush, Walter Reed, and Albert Sabin, to name a very few- and has been fertile ground for medical historians . The advances made in those early investigations are all the more remarkable for the limited tools available at the time. The demonstration of a viral etiology for dengue fever, the recognition of mosquitoes as the vector for transmission to humans, and the existence of multiple viral variants (serotypes) with only partial cross-protection were all accomplished prior to the ability to culture and characterize the etiologic agent. Research on dengue in this period was typically driven by circumstances. Epidemics of dengue created public health crises, although these were relatively short-lived in any one location, as the population of susceptible individuals quickly shrank. Military considerations became as a major driving force for research. With the introduction of large numbers of non-immune individuals into endemic areas, dengue could cripple military readiness, taking more soldiers out of action than hostile fire. Dengue and dengue hemorrhagic fever, which assumed pandemic proportions during the latter half of the last century, have shown no indication of slowing their growth during this first decade of the twenty-first century. Challenges remain in understanding the basic mechanisms of viral replication and disease pathogenesis, in clinical management of patients, and in control of dengue viral transmission. Nevertheless, new tools and insights have led to major recent scientific advances. As the first candidate vaccines enter large-scale efficacy trials, there is reason to hope that we may soon "turn the corner" on this disease.

Author : Laura Rivino
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.71/5 ( download)

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Download or read book Dengue Virus-Specific T Cell Immunity written by Laura Rivino and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Simona Zompi
Publisher : Frontiers Media SA
ISBN 13 : 2889195112
Total Pages : 98 pages
Book Rating : 4.14/5 ( download)

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Download or read book Protective Immune Response to Dengue Virus Infection and Vaccines: perspectives from the field to the bench written by Simona Zompi and published by Frontiers Media SA. This book was released on 2015-04-14 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dengue is the most important mosquito-transmitted viral disease in humans. Half of the world population is at risk of infection, mostly in tropical and sub-tropical areas. The World Health Organization (WHO) estimates that 50 to 100 million infections occur yearly, with 50,000 to 100,000 deaths related to dengue, mainly in children. Recent estimates show higher numbers, up to three times more, with 390 million estimated dengue infections per year, among which 96 million apparent infections (Bhatt et al. 2013). Initially localized to South-East Asia, dengue virus (DENV) started its spread in Latin America in the 80’s. Little is known about DENV spread in Africa, but multiple seroprevalence surveys over several years are now clearly showing endemic areas in East and West Africa (Brady et al. 2013). Finally, due to global warming and intense traveling there is a risk of global spread towards more temperate regions, and both US Key islands (FL) and southern Europe recently faced DENV outbreaks. There are currently no specific treatments or vaccines available. Even though several dengue vaccines are in the pipeline, clear correlates of protection are still lacking. The recent failure of the live-attenuated Sanofi vaccine Phase 2b trial (Sabchareon et al. 2013) and the lack of correlation between clinical protection and in vitro neutralization assays, clearly underlines the necessity to better understand the role of the different components of the immune system in protection against dengue virus infection and the requirement for the development of additional and/or improved predictive assays. The aim of this research topic is to provide novel data, opinions and literature reviews on the best immune correlates of protection and recent advances in the immune response to DENV infection that can allow rapid progress of dengue vaccines. Authors can choose to submit original research papers, reviews or opinions on pre-clinical or clinical observations that will help unify the field, with perspectives from epidemiology, virology, immunology and vaccine developers. This research topic will discuss different aspects of the protective immune response to DENV that can influence vaccine development. It will include a review of epidemiological data generated in the field, which will address spatio-temporal diversity of DENV epidemics, the importance of cross-reactive protection and of the time-interval between infections as a predictor of disease. It will further include a review of the role of both the innate and adaptive immunity in DENV infection control, and discuss the usefulness of new improved animal models in dissecting the role of each immunological compartment, which will help define new correlate of immune protection. New data concerning the DENV structure and anti-dengue antibody structure will address the necessity of improved neutralization assays. The ultimate test to prove vaccine efficacy and study immune correlates of protection in humans before large trials will open up the discussion on human DENV challenges using controlled attenuated viral strains. Finally, the role of vaccines, administered in flavi-immune populations, in the modification of future epidemics will also be approached and will include novel studies on mosquitoes infection thresholds.

Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9241547871
Total Pages : 159 pages
Book Rating : 4.71/5 ( download)

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Download or read book Dengue written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is intended to contribute to prevention and control of the morbidity and mortality associated with dengue and to serve as an authoritative reference source for health workers and researchers. These guidelines are not intended to replace national guidelines but to assist in the development of national or regional guidelines. They are expected to remain valid for five years (until 2014), although developments in research could change their validity.--Publisher's description.

Author : Jorge Abelardo Falcón-Lezama
Publisher : BoD – Books on Demand
ISBN 13 : 1789849993
Total Pages : 182 pages
Book Rating : 4.98/5 ( download)

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Download or read book Dengue Fever written by Jorge Abelardo Falcón-Lezama and published by BoD – Books on Demand. This book was released on 2019-01-30 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over 70 years, dengue fever has challenged health systems in every region of the World. It has evolved from a benign febrile illness from the tropics to a major concern in urban settlements, overwhelming health infrastructure with large outbreaks, as it continues to teach us important lessons with its complexities. This book intends to review the latest updates on dengue fever, the tools available for its study and control, and promising technologies currently in the pipeline. With this work, the editors wish to provide students with an updated reference text on the basics of this disease as well as researchers and academics, with a useful document to understand the current outlook and the perspectives for the future.

Author : Sazaly Abu Bakar
Publisher :
ISBN 13 :
Total Pages : 2 pages
Book Rating : 4.31/5 ( download)

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Download or read book Advances in Dengue Virus Research written by Sazaly Abu Bakar and published by . This book was released on 1999 with total page 2 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present study was undertaken to investigate the pathogenesis of dengue. It was found that almost all DF patient sera had detectable presence of specific antibodies that recognized specific dengue virus proteins. It was also noted that dengue virus infection resulted in activation of cellular apoptotic responses. Binding of dengue viruses to mosquito cells was determined to be mediated by a 49 kD cellular protein. [Authors' abstract].

Author : Alfonso J. Rodriguez-Morales
Publisher : BoD – Books on Demand
ISBN 13 : 1789848245
Total Pages : 179 pages
Book Rating : 4.43/5 ( download)

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Download or read book Current Topics in Tropical Emerging Diseases and Travel Medicine written by Alfonso J. Rodriguez-Morales and published by BoD – Books on Demand. This book was released on 2018-12-19 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tropical emerging diseases pose a significant risk for the circulation of old and new pathogens in areas previously unknown, also implying the possibility of new morbidities and mortalities and new consequences for naïve populations. Globalization, migration and travel are key factors for tropical diseases, and represent the need for integration of tropical medicine, travel medicine and epidemiology in the understanding of such complex situations. Neglected tropical diseases such as leprosy or Chagas disease, arboviral diseases, HIV, Ebola, and arenaviral infections are just a few examples. This book tries to update significant epidemiological and clinical research in many aspects with a multinational perspective.

Author : Huan-Yao Lei
Publisher :
ISBN 13 : 9788130802909
Total Pages : 309 pages
Book Rating : 4.02/5 ( download)

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Download or read book Dengue Disease written by Huan-Yao Lei and published by . This book was released on 2008-01-01 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: PART 1 -- Dengue virus infection is an emerging infectious disease with an increasing prevalence of global scale, especially in the tropical countries. Several socioeconomic and environmental factors are responsible for the surging of dengue outbreaks in the 21st century. The easy access to transportation and global urbanization contribute most significantly to the prevalence of dengue infection in the late 20th century. The poor environmental conditions in many countries make the control of mosquito vector a difficult or even impossible task and the dengue outbreaks therefore become an uncontrollable issue in these countries. In central/southern America and southeastern Asia, dengue outbreaks up to a scale of beyond hundred thousands cases occurred annually. The control measures depend largely on improving the proper management of patients with dengue hemorrhagic fever/ dengue shock syndrome (DHF/DSS). The past decades have witnessed the improvement of mortality of DHF/DSS from around 10% to the current 0.1% in these DHF/DSS cases. However, the development of dengue vaccine turned out to be unsuccessful using the live attenuated viruses due to the incomplete immune response to the tetravalent vaccine and the high morbidity associated with vaccination. The story behind the failure of vaccine development reflects our lack of understanding regarding the complex immunopathogenesis of virus-host interaction in dengue virus infection. In the past years, the scientific field started to understand the importance of basic researches in the development of anti-virus compounds and vaccine development in dengue virus infection. Under the combined efforts of Pediatric Dengue Vaccine Initiative (PDVI) led by Professor Scott Halstead, and the establishment of Novartis Institute for Tropical Diseases in Singapore, a significant improvement in our understanding of the virology, virus-host interaction, and immune response in dengue infection have been achieved. In Taiwan, the dengue research is actively sponsored by National Health Research Institutes starting from 2000. Since then, several progresses such as the epitpoe mapping for the antibody dependent enhancement and the development of autoantibodies against endothelial cells and platelets have been achieved. Significant progresses have also been made in diagnostic technology and molecular epidemiology of dengue infections. The urgent demand in dengue research is to develop a good animal model to study the pathogenesis and also for the development of anti-viral compounds and dengue vaccine. Based on the results obtained from the researches in the past decade, scientific knowledge on basic and clinical fields of dengue infection accumulated and a special book to summarize these knowledge becomes necessary. Under the coordination of Professor Lei HY in the National Cheng Kung University Medical School, scientists in Taiwan and in Asian regions contribute their expertise in each chapter to publish a book to address the specific issues in each field of dengue virus infection. These knowledge will not only provide scientific data in each specific topic but also offer the direction for future studies. Hopefully, we can reach some breakthrough in the coming years to develop strategy for anti-viral compounds and vaccine development. PART 2 -- Dengue fever and Dengue hemorrhagic fever is an important tropical infectious disease, afflicting millions of people every year. It is also alarmingly spreading northward to North America. The virus has been studied for many years and its molecular structure is thoroughly known. It is a flavivirus and consists of 4 serotypes (and genotypes). It is spread through mosquito as a vector. Repeated infections with viruses of different genotypes result in severe hemorrhagic fever. Despite such wealth of knowledge, Dengue fever and Dengue virus remain a scientific and medial challenge. First of all, the mechanism of Dengue hemorrhagic fever remains elusive. Is it a viral load problem? Or, is it due to genetic makeup of certain hemorrhagic virus strains? Or, as suggested by several articles in this book, is it an autoimmune disease? Convincing scientific evidence presented in this book showed a pathogenic role for the auto-antibodies against some viral proteins. Also, cytokine storms may trigger the pathology. This hypothesis was a major contribution from Dengue researchers in Taiwan previously and is elaborated by several chapters in this book. The understanding of Dengue pathogenesis has been hampered by lack of animal models for hemorrhagic fever. An animal model is described in this book. Second, the diagnosis of Dengue fever remains slow and time-consuming. It used to rely mainly on serological tests. This book outlined molecular detection and biochip detection methods, which may facilitate Dengue diagnosis. Third, treatment for Dengue hemorrhagic fever remains mainly symptomatic. There are still no effective antivirals available for Dengue. This book did not address this issue but outlined the strategies for managing Dengue hemorrhagic fever. Finally, the most important issue concerns vaccines. Several clinical trials for Dengue vaccines are currently ongoing. The most challenging issue in Dengue vaccine development is whether the vaccine can produce broad enough immunity to ensure that all the potential virus strains of different genotypes are covered by the antibodies induced. Only the complete coverage can prevent viral superinfection, which may cause hemorrhagic fever. A summary chapter by the editor Dr. Huan-Yao Lei elegantly discusses the challenges and opportunities for Dengue vaccine development. Taiwan has been a stronghold for Dengue research. All the authors in this book are from various institutions in Taiwan. This collection of articles provides excellent glimpses into the quality of research in this regard in this country and also represents the state of arts in Dengue virus research. Besides the topics discussed above, this book also addresses virology of Dengue virus, including virus entry, apoptosis, autophagy, production of interferon and immune responses. It is rare that there is such a concentration of Dengue researchers in a small country like Taiwan. It is even rarer that these scientists together will contribute to a book like this. As a fellow virologist, I am proud to write a preface for this book. PART 3 -- The global prevalence of dengue has grown dramatically and is now endemic in more than 100 countries. There are at least 50 million cases of dengue infection and several hundred thousand cases of dengue hemorrhagic fever (DHF) per year. Dengue disease is an important health problem in tropical or sub-tropical areas and the DHF is the leading cause of hospitalization for children in Southeastern Asia. So far, there is no effective dengue vaccine, although several candidate vaccines are currently being evaluated. Serious dengue disease involves life-threatening complications such as vascular leakage and hemorrhagic diathesis. In endemic areas such as southeastern Asia or Latin America, most of the DHF/DSS are children while some are infants. However, in non-endemic areas like Taiwan, the majority of the DHF/DSS cases are adults and the infected elders tend to have high mortality. Taiwan s dengue outbreaks also have a unique type of transmission: starting from imported cases from abroad, spreading out locally, and ending in the winter. This pattern repeats every year. The dengue disease pattern in Taiwan represents a new type of epidemiology which is different from that in the endemic area of Southeast Asia. In this book, a comprehensive review from dengue epidemiology, diagnosis, clinical, dengue genome, cellular response post dengue virus infection, animal model, dengue-induced autoimmunity, antibody-dependent enhancement, immunopathogenesis, patient management, to dengue vaccine development is covered. All chapters are contributed by Taiwanese dengue researchers. Based on the Dengue Research Team in Department of Microbiology and Immunology, National Cheng Kung University Medical College, we have established a vigorous research network linking various laboratories in National Taiwan University Medical College, Academia Sinica, Center for Disease Control, and National Defense Medical Center with the financial support for dengue program project by National Health Research Institute. We also collaborate with dengue investigators from Canada, Thailand, and Vietnam. Through intensive communication, research ideas are generated, fine-tuned and executed by members from different laboratories within an interactive and cooperative atmosphere. Using approaches aimed at the patient, virus, animal, cellular, and molecular levels, an intensive study of dengue pathogenesis by this highly-integrated research network is helping to develop new understanding and strategies to cope with dengue disease. In particularly, acute dengue virus infection can induce autoimmunity due to molecular mimicry between dengue NS-1, prM and platelet, endothelial cells. A new autoantibody-associated immunopathogenesis is proposed and offers new insights into the molecular mechanisms underlying DHF/DSS, and will have impact on the future design of safe and protective dengue vaccines.