Forensic Investigative Genetic Genealogy And Fine Scale Structure Of Human Populations

Author : Guanglin He
Publisher : Frontiers Media SA
ISBN 13 : 2832513670
Total Pages : 150 pages
Book Rating : 4.75/5 ( download)

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Download or read book Forensic Investigative Genetic Genealogy and Fine-Scale Structure of Human Populations written by Guanglin He and published by Frontiers Media SA. This book was released on 2023-02-03 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Dominic Nelson
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.59/5 ( download)

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Download or read book Dealing with Relatives written by Dominic Nelson and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "All of humanity, and indeed all living things, are connected by a complex web of ancestral relationships. How much of this shared pedigree is known, how much can be inferred, and how completely it can be described, are important factors in interpreting present-day genetic diversity and discovering genetic contributions to disease. The challenges of using pedigree information are twofold. First, in human populations, genealogical data is often unavailable or incomplete. Second, when such datasets are available, there are significant computational challenges to using them. In both cases the response has often been to use approximate models of pedigree structure, which removes the need for complete historical data and simplifies analysis. But genetic cohorts are growing, and increased sample sizes necessitate more detailed models of relatedness.The work presented here represents a first step in explicitly modeling the relatedness of millions of individuals, and using it to understand the fine-scale diversity of whole populations, as well as the genetic architecture of rare diseases. First we developed a software package, ISGen (Importance Sampling in Genealogies) for inferring the ancestral origin of rare alleles in population-scale pedigrees, as well as their distribution among present-day individuals, in a fully Bayesian framework. Similar analysis had never been possible before at that scale, and as a proof-of-concept we analyzed the distribution of the allele causing Chronic Atrial and Intestinal Dysrhythmia (CAID) within the province of Quebec. Using observations of only 11 patients and 4 heterozygous carriers of the allele, we estimated the allele frequency in 26 geographic regions of the province, finding the highest expected frequency in Charlevoix, where no carriers had yet been observed.Despite its value for supporting the design of screening programs for rare diseases, ISGen is limited to rare alleles and a single locus. Extending to whole-genome inference is a daunting challenge, and can be aided significantly by high-quality data with a known transmission history. Simulations are a natural source of such data, yet the most efficient simulation frameworks were based on coalescent models with known biases for long genomic regions and large sample sizes. We developed two tools to address this issue. One is an extension to the state-of-the-art msprime coalescent simulator which allows simulations under a Wright-Fisher model. This extension makes use of the highly efficient algorithms and data structures of msprime, and we showed more realistic relatedness among simulated individuals as well as improved performance over coalescent simulations at whole-genome scale. We then continued to develop this extension to allow simulations to be performed within a predefined pedigree, and when used with the population-scale genealogy of Quebec, Canada we showed that simulated cohorts captured much of the structure of a real dataset from the same population, and significantly more than comparable simulations of a randomly-mating population. To show the potential of large-scale pedigree simulations more generally, we further described how pedigree simulations can aid in the design of sequencing cohorts for imputation, and be used to detect rare-variant associations while explicitly accounting for relatedness among cohort members"--

Author : Dragan Primorac
Publisher : CRC Press
ISBN 13 : 0429672357
Total Pages : 533 pages
Book Rating : 4.54/5 ( download)

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Download or read book Forensic DNA Applications written by Dragan Primorac and published by CRC Press. This book was released on 2023-04-26 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensic DNA Applications: An Interdisciplinary Perspective, Second Edition is fully updated to outline the latest advances in forensic DNA testing techniques and applications. It continues to fill the need for a reference book for people working in the field of forensic molecular biology testing and research as well as individuals investigating and adjudicating cases involving DNA evidence, whether they be civil or criminal cases. DNA techniques have greatly impacted obvious traditional forensic areas, but such advances have also positively affected myriad new areas of research and inquiry. It is possible today to think about solving forensic problems that were simply unheard of even a few years ago. As such, the book pulls all relevant research and applied science together into a detailed and comprehensive collection. Part I begins with the history and development of DNA typing and profiling for criminal and civil purposes. It discusses the statistical interpretation of results with case examples, mitochondrial DNA testing, Y single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs), and X SNP and STR testing. It also explores low copy number DNA typing, mixtures, and quality assurance and control. Part II moves on to cover the various uses and applications of analyzing collected physical evidence, victim identification in mass disasters, analyzing animal DNA, forensic botany, and other unique applications. Part III is dedicated to the latest advances and developments in human molecular biology and Part IV looks at policies and laws and ethics governing DNA evidence, and its utilization in various cases and the courts. Forensic DNA Applications, Second Edition covers cutting-edge research and advancements in the field and is the most up-to-date reference available. Edited and contributed to by the world's foremost leaders in the field, it is a must-have reference for established professionals, and an essential resource to legal professionals—lawyers and judges dealing with civil and criminal cases involving DNA technology—as well as students entering the fields of genetics and forensic DNA analysis.

Author : Debbie Parker Wayne
Publisher :
ISBN 13 : 9781733694902
Total Pages : 414 pages
Book Rating : 4.00/5 ( download)

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Download or read book Advanced Genetic Genealogy written by Debbie Parker Wayne and published by . This book was released on 2019-03-20 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Genetic Genealogy: Techniques and Case Studies is a textbook for an advanced DNA course for genealogist. It takes those with an intermediate-level understanding of genetic genealogy to the next level. Case studies demonstrate how to analyze the DNA test results, correlate with documentary evidence, and write about findings.

Author : Kurt Weising
Publisher : CRC Press
ISBN 13 : 1420040049
Total Pages : 470 pages
Book Rating : 4.43/5 ( download)

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Download or read book DNA Fingerprinting in Plants written by Kurt Weising and published by CRC Press. This book was released on 2005-02-28 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the explosive development of new molecular marker techniques over the last decade, newcomers and experts alike in the field of DNA fingerprinting will find an easy-to-follow guide to the multitude of techniques available in DNA Fingerprinting in Plants: Principles, Methods, and Applications, Second Edition. Along with step-by-step annotated p

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309047986
Total Pages : 353 pages
Book Rating : 4.82/5 ( download)

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Download or read book Assessing Genetic Risks written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

Author : Mark Jobling
Publisher : Garland Science
ISBN 13 : 1317952251
Total Pages : 1557 pages
Book Rating : 4.51/5 ( download)

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Download or read book Human Evolutionary Genetics written by Mark Jobling and published by Garland Science. This book was released on 2013-06-25 with total page 1557 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Evolutionary Genetics is a groundbreaking text which for the first time brings together molecular genetics and genomics to the study of the origins and movements of human populations. Starting with an overview of molecular genomics for the non-specialist (which can be a useful review for those with a more genetic background), the book shows h

Author : Nina Amelung
Publisher : Springer Nature
ISBN 13 : 9811581835
Total Pages : 155 pages
Book Rating : 4.30/5 ( download)

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Download or read book Modes of Bio-Bordering written by Nina Amelung and published by Springer Nature. This book was released on 2020-10-30 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book explores how biometric data is increasingly flowing across borders in order to limit, control and contain the mobility of selected people, namely criminalized populations. It introduces the concept of bio-bordering, using it to capture reverse patterns of bordering and ordering practices linked to transnational biometric data exchange regimes. The concept is useful to reconstruct how the territorial foundations of national state autonomy are partially reclaimed and, at the same time, partially purposefully suspended. The book focuses on the Prüm system, which facilitates the mandatory exchange of forensic DNA data amongst EU Member States. The Prüm system is an underexplored phenomenon, representing diverse instances of bio-bordering and providing a complex picture of the hidden (dis)integration of Europe. Particular legal, scientific, technical and political dimensions related to the governance and uses of biometric technologies in Germany, the Netherlands, Poland, Portugal and the United Kingdom are specifically explored to demonstrate both similar and distinct patterns.

Author : John M. Butler
Publisher : Academic Press
ISBN 13 : 0080961762
Total Pages : 519 pages
Book Rating : 4.67/5 ( download)

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Download or read book Fundamentals of Forensic DNA Typing written by John M. Butler and published by Academic Press. This book was released on 2009-09-30 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Forensic DNA Typing is written with a broad viewpoint. It examines the methods of current forensic DNA typing, focusing on short tandem repeats (STRs). It encompasses current forensic DNA analysis methods, as well as biology, technology and genetic interpretation. This book reviews the methods of forensic DNA testing used in the first two decades since early 1980’s, and it offers perspectives on future trends in this field, including new genetic markers and new technologies. Furthermore, it explains the process of DNA testing from collection of samples through DNA extraction, DNA quantitation, DNA amplification, and statistical interpretation. The book also discusses DNA databases, which play an important role in law enforcement investigations. In addition, there is a discussion about ethical concerns in retaining DNA profiles and the issues involved when people use a database to search for close relatives. Students of forensic DNA analysis, forensic scientists, and members of the law enforcement and legal professions who want to know more about STR typing will find this book invaluable. Includes a glossary with over 400 terms for quick reference of unfamiliar terms as well as an acronym guide to decipher the DNA dialect Continues in the style of Forensic DNA Typing, 2e, with high-profile cases addressed in D.N.A.Boxes-- "Data, Notes & Applications" sections throughout Ancillaries include: instructor manual Web site, with tailored set of 1000+ PowerPoint slides (including figures), links to online training websites and a test bank with key

Author : Dr. G. Suarez-Kurtz
Publisher : CRC Press
ISBN 13 : 1498713793
Total Pages : 222 pages
Book Rating : 4.95/5 ( download)

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Download or read book Pharmacogenomics in Admixed Populations written by Dr. G. Suarez-Kurtz and published by CRC Press. This book was released on 2007-08-03 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ethnic specificity has become an integral part of research in the overlapping sciences of pharmacogenetics and pharmacogenomics. Pharmacogenomics in Admixed Populations was conceived to compile pharmacogenetic/-genomic (PGx) data from peoples of four continents: Africa, America, Asia and Oceania, where admixture and population stratification occurs