Fidelity And Quality Control In Gene Expression

Author : Assen Marintchev
Publisher : Academic Press
ISBN 13 : 0123864976
Total Pages : 267 pages
Book Rating : 4.70/5 ( download)

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Download or read book Fidelity and Quality Control in Gene Expression written by Assen Marintchev and published by Academic Press. This book was released on 2012-01-27 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this volume is to provide a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. In addition to discussing processes with direct contribution to translation fidelity, such as aminoacylation of tRNAs and translation elongation itself, special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting. Provides a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation Special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting

Author :
Publisher : Academic Press
ISBN 13 : 0123864984
Total Pages : 267 pages
Book Rating : 4.87/5 ( download)

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Download or read book Fidelity and Quality Control in Gene Expression written by and published by Academic Press. This book was released on 2012-01-25 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this volume is to provide a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. In addition to discussing processes with direct contribution to translation fidelity, such as aminoacylation of tRNAs and translation elongation itself, special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting. Provides a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation Special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting

Author : Nancy L. Craig
Publisher : Oxford University Press, USA
ISBN 13 : 0198788657
Total Pages : 1018 pages
Book Rating : 4.52/5 ( download)

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Download or read book Molecular Biology written by Nancy L. Craig and published by Oxford University Press, USA. This book was released on 2021-01-20 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fresh, distinctive approach to the teaching of molecular biology. With its focus on key principles, its emphasis on the commonalities that exist between the three kingdoms of life, and its integrated coverage of experimental methods and approaches, Molecular Biology is the perfect companion to any molecular biology course.

Author : Lynne E. Maquat
Publisher : CRC Press
ISBN 13 : 1498713394
Total Pages : 277 pages
Book Rating : 4.99/5 ( download)

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Download or read book Nonsense-Mediated mRNA Decay written by Lynne E. Maquat and published by CRC Press. This book was released on 2006-02-28 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonsense-Mediated mRNA Decay is the first book devoted to nonsense-mediated mRNA decay (NMD). The rationale for such a book is the enormous information that studies of NMD have provided on the intricacies of post-transcriptional gene expression. The first five sections of the book are divided according to organism and begin with chapters on S. cere

Author : Sandosh Padmanabhan
Publisher : Academic Press
ISBN 13 : 0123868831
Total Pages : 1119 pages
Book Rating : 4.31/5 ( download)

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Download or read book Handbook of Pharmacogenomics and Stratified Medicine written by Sandosh Padmanabhan and published by Academic Press. This book was released on 2014-04-28 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Author : Zonglin Lewis Liu
Publisher : Springer Science & Business Media
ISBN 13 : 3642214673
Total Pages : 311 pages
Book Rating : 4.77/5 ( download)

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Download or read book Microbial Stress Tolerance for Biofuels written by Zonglin Lewis Liu and published by Springer Science & Business Media. This book was released on 2011-09-15 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of sustainable and renewable biofuels is attracting growing interest. It is vital to develop robust microbial strains for biocatalysts that are able to function under multiple stress conditions. This Microbiology Monograph provides an overview of methods for studying microbial stress tolerance for biofuels applications using a systems biology approach. Topics covered range from mechanisms to methodology for yeast and bacteria, including the genomics of yeast tolerance and detoxification; genetics and regulation of glycogen and trehalose metabolism; programmed cell death; high gravity fermentations; ethanol tolerance; improving biomass sugar utilization by engineered Saccharomyces; the genomics on tolerance of Zymomonas mobilis; microbial solvent tolerance; control of stress tolerance in bacterial host organisms; metabolomics for ethanologenic yeast; automated proteomics work cell systems for strain improvement; and unification of gene expression data for comparable analyses under stress conditions.

Author : Robert Resnik
Publisher : Elsevier Health Sciences
ISBN 13 : 1437721354
Total Pages : 1301 pages
Book Rating : 4.55/5 ( download)

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Download or read book Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice E-Book written by Robert Resnik and published by Elsevier Health Sciences. This book was released on 2008-11-25 with total page 1301 pages. Available in PDF, EPUB and Kindle. Book excerpt: In your practice, you require advanced knowledge of the obstetrical, medical, genetic and surgical complications of pregnancy and their effects on the mother and fetus. With both basic science and clinical information, six new chapters, and an updated color design, you need look no further than the 6th edition of this long-time best seller. Includes both basic science and clinical information to give you comprehensive knowledge of the biology of pregnancy. Acts as an excellent resource for OB/GYNs studying for their Maternal-Fetal Medicine boards — and for practitioners who need quick access to practical information. Provides an updated and focused reference list to keep you up to date on the standards of care in maternal-fetal medicine today. Keeps you current with a new section: Disorders at the Maternal-Fetal Interface...and 6 new chapters: Biology of Parturition, Developmental Origins of Health and Disease, Intrapartum Assessment of Fetal Health, Pathogenesis of Pre-term Birth, Maternal and Fetal Infectious Disorders, and Benign Gynecological Conditions of Pregnancy. Features over 50% new authorship with increased focus on international perspectives. Includes the following hot topics in Maternal-Fetal Medicine: o Biology of Parturition o Fetal Growth o Prenatal Genetic Screening and Diagnosis o Fetal Cardiac Malformations and Arrhythmias o Thyroid Disease and Pregnancy o Management of Depression and Psychoses during Pregnancy and the Puerperium Focuses on evidence based medicine, the current best practice in MFM for diagnosing and treating high risk pregnancies. Includes new illustrations and an updated, color design.

Author : K.M.J. Menon, PhD
Publisher : Springer
ISBN 13 : 3319251244
Total Pages : 347 pages
Book Rating : 4.40/5 ( download)

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Download or read book Post-transcriptional Mechanisms in Endocrine Regulation written by K.M.J. Menon, PhD and published by Springer. This book was released on 2015-12-30 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.

Author : Kif Liakath-Ali
Publisher : Frontiers Media SA
ISBN 13 : 2832540732
Total Pages : 171 pages
Book Rating : 4.32/5 ( download)

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Download or read book Alternative Splicing in Brain Function written by Kif Liakath-Ali and published by Frontiers Media SA. This book was released on 2023-12-13 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional and structural intricacies of biological systems emerge from the complex nature of the genome. A key aspect of genome complexity can be attributed to the process of alternative splicing of precursor mRNA (or pre-mRNA), during which introns are removed and exons are selectively spliced together. This highly regulated process generates different mature mRNA transcripts from a single gene and is widespread throughout the eukaryotic evolution. The majority of the genes expressed in the mammalian central nervous system undergo extensive alternative splicing. Some genes can generate more than a thousand isoforms resulting in diverse proteoforms that can differ in their function, binding preference, catalytic activity, and localization. Perturbation in alternative splicing has been linked to many neurological disorders. Despite its significance, we still lack a comprehensive understanding of its role in neuronal function. Recent studies suggest that alternative splicing is a regulator of tissue identity and development. This is particularly relevant to the brain where developmental regulation and heterogenous cell population play a crucial role in shaping its function. For a long time, technological limitations in detecting and measuring alternatively spliced transcripts hindered the progress in understanding the biology of alternative splicing. Recent advances in long-read and native mRNA sequencing and robust computational tools allow us to capture and quantify in their full-length form. Public transcriptomics datasets can be utilized for the meta-analysis of alternative splicing landscapes of various experimental conditions and disease samples. In addition, protein isoform detection complements mRNA isoform levels. Given its biological significance and recent advances, the objective of this Research Topic is to assemble current knowledge, views, and challenges in the studies of alternative splicing in brain function.

Author : Maritza Jaramillo
Publisher : Frontiers Media SA
ISBN 13 : 2889637891
Total Pages : 228 pages
Book Rating : 4.98/5 ( download)

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Download or read book RNA Regulation in Development and Disease written by Maritza Jaramillo and published by Frontiers Media SA. This book was released on 2020-06-15 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: