Epigenetics Territory And Cancer

Author : Parvin Mehdipour
Publisher : Springer
ISBN 13 : 9401796394
Total Pages : 538 pages
Book Rating : 4.92/5 ( download)

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Download or read book Epigenetics Territory and Cancer written by Parvin Mehdipour and published by Springer. This book was released on 2015-03-18 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthropology’. Translating multi-disciplinary research into therapeutic design is at the core of this book. Readers may explore how cancer management involves unmasking the involved networks and the interactive status of different genes to achieve the appropriate methylome based therapy. Early chapters explore fundamental aspects and brain tumours, whilst later chapters investigate breast cancer and various other cancers, and the final chapter presents an evolutionary insight in cancer epigenetics, considering that the epigene is beyond DNA methylation, RNA interference and histone modification in cancer development. This book will be of interest to researchers in different medical and scientific fields, including clinical management (diagnosis, prognosis, prediction, prevention, and guidelines), genetic education, nutrition and nutrigenomics, industrial chemistry, and drug innovation. Because of the unique bridging between science and medicine this book will also be useful as an educational and translational research package.

Author : Fazlul H. Sarkar
Publisher : Springer Science & Business Media
ISBN 13 : 9400766122
Total Pages : 287 pages
Book Rating : 4.29/5 ( download)

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Download or read book Epigenetics and Cancer written by Fazlul H. Sarkar and published by Springer Science & Business Media. This book was released on 2013-05-29 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. All the articles have been carefully chosen to represent several cancer systems with state of our knowledge on the role of epigenetic deregulation of microRNAs (miRNAs) and their target mRNAs along with epigenetic deregulation of mRNAs. This book also illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in modulating the epigenetic reprogramming of miRNAs and mRNAs for the prevention and/or treatment of human malignancies. It is well known that genetic aberrations, especially inherited through parents (somatic genetic alterations) contribute to the development of less than 10% of all cancer yet epigenetic alterations in genes especially through selective methylation and acetylation appears to be responsible for the development and progression of the vast majority of all cancers. Therefore, understanding the role of epigenetics in the regulation of genes especially through deregulated expression of miRNAs as presented in this book will allow scientists to devise targeted therapeutic strategies for re-expression of the lost genes or down-regulate the genes that are over-expressed in order to eradicate cancer. It is hoped that targeting epigenetics will not only target cancer cells but it will also target the tumor microenvironment (more like the entire tumor environment such as the entire host) for achieving better treatment outcomes for patients diagnosed with cancer which will lead to achieve the long-term objective for complete eradication of cancer. This book contains fifteen chapters which begins with the concept of systems and network biology for investigating the epigenetics of cancer followed by a series of articles on the role of miRNAs and their target genes in the biology of pancreatic cancer and other cancers such as breast, kidney, prostate and and colon. Since it is becoming increasingly clear that cancer stem cells (CSCs) are important in the development and progression of cancer, and CSCs are important in therapeutic resistance, treatment failure and tumor recurrence, thus the importance of CSCs and epigenetics has been highlighted by a very timely article on epigenetic variations of stem cell markers in cancer including miRNAs. Moreover, just targeting heterogeneous cancer cell populations may not be optimal to eradicate tumors and for which one must take a holistic approach for developing drugs that could also target the tumor microenvironment and tumor dormancy that are regulated through epigenetics. Keeping abreast with this thought process the concluding chapter provides a concept towards curative cancer therapy with maspin, which could be a unique window of opportunity to target tumor dormancy. Therefore, it suggest that targeting the tumor dormancy and the tumor microenvironment using novel therapeutics specifically by targeting epigenetics would become the future of medicine.

Author : Adam R. Karpf
Publisher : Springer Science & Business Media
ISBN 13 : 1441999671
Total Pages : 355 pages
Book Rating : 4.72/5 ( download)

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Download or read book Epigenetic Alterations in Oncogenesis written by Adam R. Karpf and published by Springer Science & Business Media. This book was released on 2012-09-06 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

Author : Trygve Tollefsbol
Publisher : CRC Press
ISBN 13 : 1420045806
Total Pages : 472 pages
Book Rating : 4.02/5 ( download)

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Download or read book Cancer Epigenetics written by Trygve Tollefsbol and published by CRC Press. This book was released on 2008-09-19 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being de

Author : Tapas Kumar Kundu
Publisher : Springer Science & Business Media
ISBN 13 : 9400745257
Total Pages : 698 pages
Book Rating : 4.54/5 ( download)

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Download or read book Epigenetics: Development and Disease written by Tapas Kumar Kundu and published by Springer Science & Business Media. This book was released on 2012-11-13 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.

Author : Manoj K. Mishra
Publisher : Springer
ISBN 13 : 3319249517
Total Pages : 246 pages
Book Rating : 4.13/5 ( download)

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Download or read book Epigenetic Advancements in Cancer written by Manoj K. Mishra and published by Springer. This book was released on 2016-05-04 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression. Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and non-coding RNAs expression are involved in a complex network of regulating expression of oncogenes and tumor suppressor genes and constitute an important event of the multistep process of carcinogenesis. Recent advances in the understanding of the epigenetic regulation and detailed information of these epigenetic changes in various cancers provide new avenues of advancements in diagnostics, prognostics, and therapies of this highly fatal disease.

Author : Sabita Saldanha
Publisher : Academic Press
ISBN 13 : 0128134607
Total Pages : 392 pages
Book Rating : 4.03/5 ( download)

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Download or read book Epigenetic Mechanisms in Cancer written by Sabita Saldanha and published by Academic Press. This book was released on 2017-11-16 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes. Offers broad coverage that is applicable to audiences in various area of cancer research - population studies, diagnostics, prognosis, prediction, therapy, risk, etc. Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer management Covers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesis Features contributions by leading experts in the field Provides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs

Author : Anupam Bishayee
Publisher : Academic Press
ISBN 13 : 0128125667
Total Pages : 442 pages
Book Rating : 4.63/5 ( download)

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Download or read book Epigenetics of Cancer Prevention written by Anupam Bishayee and published by Academic Press. This book was released on 2018-11-27 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics of Cancer Prevention, Volume Ten is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, together they will set an advanced understanding for the reader in this upcoming field of chemoprevention influencing epigenetics. This book discusses molecular epigenetic targets of natural products, such as green tea polyphenols, curcumin and resveratrol, and organ specific epigenetic targets related to diverse types of cancer, for example prostate, colorectal, breast, lung and skin cancers. Additionally, it encompasses a discussion on research methods and limitations to study epigenetics and epigenomics of chemopreventive drugs and personalized cancer treatment with phytochemicals. The book is ideal for cancer researchers, health care professionals and all individuals who are interested in cancer prevention research and its clinical applications, especially in natural remedies. Lists natural agents, including nutraceuticals, and their effects on normal or tumor genome Addresses various epigenetic systems and mechanisms in the regulation and support of the mammalian genome Discusses how various parts of dietary phytochemicals can influence or modify epigenetic mechanisms in several types of cancer

Author : Xiao Zhu
Publisher : Frontiers Media SA
ISBN 13 : 2889743764
Total Pages : 183 pages
Book Rating : 4.66/5 ( download)

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Download or read book Epigenetics in Cancer: Mechanisms and Drug Development written by Xiao Zhu and published by Frontiers Media SA. This book was released on 2022-07-25 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Manel Esteller
Publisher : CRC Press
ISBN 13 : 9781420007077
Total Pages : 312 pages
Book Rating : 4.76/5 ( download)

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Download or read book Epigenetics in Biology and Medicine written by Manel Esteller and published by CRC Press. This book was released on 2008-09-17 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its