Dna Repair Disorders

Author : Chikako Nishigori
Publisher : Springer
ISBN 13 : 9811067228
Total Pages : 221 pages
Book Rating : 4.28/5 ( download)

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Download or read book DNA Repair Disorders written by Chikako Nishigori and published by Springer. This book was released on 2018-12-31 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the clinical aspects of DNA repair disorders. Nucleotide excision repair is an important pathway for humans, as it is involved in biologically fundamental functions. This work presents clinical features together with the pathogenesis of DNA repair disorders such as Xertoderma Pigmentosum (XP). Studies on animal models are included as well. Clinical feature characteristics of each clinical subtype of XP are depicted according to the genotype, giving accurate and detailed information about the clinical features in terms of gene alterations, change of protein structure, and dysfunction in some of the repair pathways. This book is unique in that it provides detailed information on clinical features from more than 100 patients with XP-A, which is characterized by very severe manifestation of skin photosensitivity and neurological dysfunction. It will give readers important knowledge for understanding the concept and molecular mechanisms of DNA repair disorders. It also describes how to treat and care for patients with XP based on vast experience in clinical practice. DNA Repair Disorders will be a useful resource not only for physicians and basic scientists who are interested in and/or take care of patients with DNA repair disorders, but also dermatologists, neurologists, and researchers in the field of radiation biology and photobiology.

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.81/5 ( download)

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Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Shamim Ahmad
Publisher : Springer Science & Business Media
ISBN 13 : 1441964487
Total Pages : 282 pages
Book Rating : 4.89/5 ( download)

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Download or read book Diseases of DNA Repair written by Shamim Ahmad and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since this book is geared to be used by varied groups of readers such as advanced students and instructors in the fields of biology and medicine, scientists and more importantly clinicians, it is considered important to provide brief accounts of the basics of DNA damage, repair, mutagenesis and cancer. The purpose of this book is to present an updated detailed account of some important additional diseases of DNA repair. It has not been possible to cover all the DNA repair deficient diseases in this volume, hence diseases such as Bloom’s syndrome, Werner’s syndrome, Nijmegen breakage syndrome, ataxia telangiectasia‐like disorder, RA D 50 deficiency, RIDDLE syndrome and others will be presented in a forthcoming volume.

Author : Adayabalam Balajee
Publisher : Springer Science & Business Media
ISBN 13 : 0387368027
Total Pages : 161 pages
Book Rating : 4.23/5 ( download)

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Download or read book DNA Repair and Human Disease written by Adayabalam Balajee and published by Springer Science & Business Media. This book was released on 2007-03-06 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.

Author : Qingyi Wei
Publisher : World Scientific
ISBN 13 : 9814477117
Total Pages : 374 pages
Book Rating : 4.16/5 ( download)

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Download or read book Dna Repair, Genetic Instability, And Cancer written by Qingyi Wei and published by World Scientific. This book was released on 2007-01-08 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. It provides a snapshot of current understanding about some of the major DNA repair pathways, including base-excision repair, nucleotide excision repair, mismatch repair, homologous recombination, and non-homologous end-joining as well as cell cycle checkpoints and translesion DNA synthesis. One of the particular emphases of the book is the link between inherited DNA repair deficiencies and susceptibility to cancer in the general population. For the first time, the book brings together a collection of review articles written by a group of active and laboratory-based investigators who have a clear understanding of the recent advances in the fields of DNA damage repair and genomic stability and their implications in carcinogenesis, new approaches in cancer therapy, and cancer prevention.

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481628453
Total Pages : 27 pages
Book Rating : 4.57/5 ( download)

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Download or read book DNA Repair-Deficiency Disorders—Advances in Research and Treatment: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair-Deficiency Disorders—Advances in Research and Treatment: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about DNA Repair-Deficiency Disorders in a compact format. The editors have built DNA Repair-Deficiency Disorders—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about DNA Repair-Deficiency Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of DNA Repair-Deficiency Disorders—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464955050
Total Pages : 22 pages
Book Rating : 4.51/5 ( download)

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Download or read book DNA Repair-Deficiency Disorders: Advances in Research and Treatment: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair-Deficiency Disorders: Advances in Research and Treatment: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about DNA Repair-Deficiency Disorders in a compact format. The editors have built DNA Repair-Deficiency Disorders: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about DNA Repair-Deficiency Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of DNA Repair-Deficiency Disorders: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Clark Chen
Publisher : BoD – Books on Demand
ISBN 13 : 9533076062
Total Pages : 586 pages
Book Rating : 4.65/5 ( download)

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Download or read book Selected Topics in DNA Repair written by Clark Chen and published by BoD – Books on Demand. This book was released on 2011-10-26 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended for students and scientists working in the field of DNA repair, focusing on a number of topics ranging from DNA damaging agents and mechanistic insights to methods in DNA repair and insights into therapeutic strategies. These topics demonstrate how scientific ideas are developed, tested, dialogued, and matured as it is meant to discuss key concepts in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

Author :
Publisher : Elsevier
ISBN 13 : 0080463444
Total Pages : 624 pages
Book Rating : 4.45/5 ( download)

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Download or read book DNA Repair, Part A written by and published by Elsevier. This book was released on 2006-06-06 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair, Part A provides detailed coverage of modern methods for molecular analysis of enzymes and enzyme systems that function in the maintenance of genome integrity. Coverage areas include base excision repair, nucleotide excision repair, translesion DNA polymerases, mismatch repair, genetic recombination, and double strand break repair. A laboratory standard for more than 40 years Over 400 volumes strong Also available on ScienceDirect Part A of a 2-part series

Author : Betsy M. Sutherland
Publisher : Springer Science & Business Media
ISBN 13 : 146130637X
Total Pages : 456 pages
Book Rating : 4.75/5 ( download)

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Download or read book DNA Damage and Repair in Human Tissues written by Betsy M. Sutherland and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical and chemical agents in the environment damage the DNA of humans, and pose a major threat to human health today, and to the genetic integrity of human populations. Although studies on isolated DNA in vitro, on prokaryotes, on mammalian cells in culture, and on laboratory animals have provided essential background information, it is now possible to study DNA damage and repair in human tissues directly. New techniques of high sensitivity, especially those not requiring radioactive labeling have made possible quantitation of DNA damage and repair, as well as detection of residual, unrepaired DNA lesions . In recent years, several investigators have taken up the challenge of studying damage and repair responses in humans, and we have chosen that work as the special focus of this Symposium. Major advances in under standing damage and responses in human skin, in blood cells and in human internal organs indicate three major themes. First, DNA damage levels in human tissues depend not only on the initial exposures, but also on the capapacity of that tissue for repair of the specific lesion type. Second, repair in human tissues may differ quantitatively and qualitatively from that in human cells in culture.