Dna And Chromatin Damage Caused By Radiation

Author : John T. Lett
Publisher : Academic Press
ISBN 13 : 1483282279
Total Pages : 520 pages
Book Rating : 4.75/5 ( download)

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Download or read book DNA and Chromatin Damage Caused by Radiation written by John T. Lett and published by Academic Press. This book was released on 2013-10-22 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Radiation Biology, Volume 17: DNA and Chromatin Damage Caused by Radiation outlines the different biological reactions to radiation. This book discusses the linear energy transfer and energy loss; DNA breaks and track structure; DNA radicals from water radicals; and radiation-induced strand breaks in isolated DNA. The radiation damage to DNA and its nearby environment; thiol radioprotectors and mechanism of action; radiolysis of water and track reactions; and computer simulation of higher order structure of DNA are also elaborated. This publication likewise covers the concept of chromatin structure; DNA supercoiling studied by sedimentation; measurement of radiation-induced DNA breakage; and analysis of damage in interphase cells. This volume is a useful reference to biologists and students concerned with DNA and chromatin damage caused by radiation.

Author : John T. Lett
Publisher :
ISBN 13 :
Total Pages : 507 pages
Book Rating : 4.78/5 ( download)

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Download or read book Advances in Radiation Biology written by John T. Lett and published by . This book was released on 1993 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : John Lett
Publisher :
ISBN 13 : 9780120354146
Total Pages : 348 pages
Book Rating : 4.44/5 ( download)

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Download or read book Relative Radiation Sensitivities of Human Organ Systems written by John Lett and published by . This book was released on 1990 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Radiation Biology, Volume 14: Relative Radiation Sensitivities of Human Organ Systems, Part II focuses on radiation sensitivities of particular human organ systems. The sensitivities are then assessed based on the severity and the rapidity in which the effects of radiation manifest. The opening chapter surveys the clinical and experimental data on approaches toward the prevention of bladder complications in clinical radiotherapy. A discussion on HeLa cells, which are of special importance in human cervical cancer therapy, is then presented. In presenting this topic, this book emph ...

Author : Theodore L. DeWeese
Publisher : Springer Science & Business Media
ISBN 13 : 144198044X
Total Pages : 282 pages
Book Rating : 4.41/5 ( download)

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Download or read book Molecular Determinants of Radiation Response written by Theodore L. DeWeese and published by Springer Science & Business Media. This book was released on 2011-03-23 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury. Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike.

Author : Heidi Carol Newman
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.15/5 ( download)

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Download or read book The Yield and Distribution of Radiation-induced DNA Damage written by Heidi Carol Newman and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author :
Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.27/5 ( download)

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Download or read book Spatiotemporal Characterization of Ionizing Radiation Induced DNA Damage Foci and Their Relation to Chromatin Organization written by and published by . This book was released on 2009 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA damage sensing proteins have been shown to localize to the sites of DSB within seconds to minutes following ionizing radiation (IR) exposure, resulting in the formation of microscopically visible nuclear domains referred to as radiation-induced foci (RIF). This review characterizes the spatio-temporal properties of RIF at physiological doses, minutes to hours following exposure to ionizing radiation, and it proposes a model describing RIF formation and resolution as a function of radiation quality and nuclear densities. Discussion is limited to RIF formed by three interrelated proteins ATM (Ataxia telangiectasia mutated), 53BP1 (p53 binding protein 1) and?H2AX (phosphorylated variant histone H2AX). Early post-IR, we propose that RIF mark chromatin reorganization, leading to a local nuclear scaffold rigid enough to keep broken DNA from diffusing away, but open enough to allow the repair machinery. We review data indicating clear kinetic and physical differences between RIF emerging from dense and uncondensed regions of the nucleus. At later time post-IR, we propose that persistent RIF observed days following exposure to ionizing radiation are nuclear?scars? marking permanent disruption of the chromatin architecture. When DNA damage is resolved, such chromatin modifications should not necessarily lead to growth arrest and it has been shown that persistent RIF can replicate during mitosis. Thus, heritable persistent RIF spanning over tens of Mbp may affect the transcriptome of a large progeny of cells. This opens the door for a non DNA mutation-based mechanism of radiation-induced phenotypes.

Author : Radiation Research Society (U.S.)
Publisher :
ISBN 13 :
Total Pages : 358 pages
Book Rating : 4.08/5 ( download)

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Download or read book Ionizing Radiation Damage to DNA written by Radiation Research Society (U.S.) and published by . This book was released on 1990-09-13 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprised of a series of short papers, dedicated exclusively to the molecular aspects of ionizing radiation-induced damage and its subsequent biological processing. Representing a scientific cross-section, with contributions by major researchers in the field, it examines new and innovative methodologies for detecting and quantifying the broad spectrum of DNA damage, spotlights the use of recombinant DNA technologies for introducing unique model lesions into DNA, and assesses their mutagenic potential.

Author : Heidi Carol Newman
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.64/5 ( download)

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Download or read book The Yields and Distribution of Radiation-induced DNA Damage written by Heidi Carol Newman and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Michael G. Simic
Publisher : Springer Science & Business Media
ISBN 13 : 1461594626
Total Pages : 567 pages
Book Rating : 4.28/5 ( download)

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Download or read book Mechanisms of DNA Damage and Repair written by Michael G. Simic and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.

Author : Miral Dizdaroglu
Publisher : Springer Science & Business Media
ISBN 13 : 1461548659
Total Pages : 502 pages
Book Rating : 4.52/5 ( download)

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Download or read book Advances in DNA Damage and Repair written by Miral Dizdaroglu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.