Cyclin Dependent Kinase 5 Cdk5

Author : Nancy Y. Ip
Publisher : Springer Science & Business Media
ISBN 13 : 0387788875
Total Pages : 326 pages
Book Rating : 4.76/5 ( download)

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Download or read book Cyclin Dependent Kinase 5 (Cdk5) written by Nancy Y. Ip and published by Springer Science & Business Media. This book was released on 2009-02-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.

Author : Nancy Y. Ip
Publisher : Springer
ISBN 13 : 9780387570440
Total Pages : 0 pages
Book Rating : 4.46/5 ( download)

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Download or read book Cyclin Dependent Kinase 5 (Cdk5) written by Nancy Y. Ip and published by Springer. This book was released on 2008-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.

Author : Narinder P. S. Bajaj
Publisher :
ISBN 13 :
Total Pages : 474 pages
Book Rating : 4.60/5 ( download)

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Download or read book Cyclin Dependent Kinase 5 (CDK5) and Neurodegeneration written by Narinder P. S. Bajaj and published by . This book was released on 1999 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : S. Guidet
Publisher : Springer Science & Business Media
ISBN 13 : 1461518091
Total Pages : 365 pages
Book Rating : 4.99/5 ( download)

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Download or read book Progress in Cell Cycle Research written by S. Guidet and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Cell Cycle Research is a new annual series designed to be the source for up-to-date research on this rapidly expanding field. Review articles by international experts examine various aspects of cell division regulation from fundamental perspectives to potential medical applications. Researchers as well as advanced undergraduate and graduate students in cell biology, biochemistry, and molecular biology will benefit from this series.

Author : Yixia Ye
Publisher :
ISBN 13 :
Total Pages : 408 pages
Book Rating : 4.64/5 ( download)

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Download or read book Activity and Regulation of Cyclin-dependent Kinase 5 (CDK5) During Cell Death written by Yixia Ye and published by . This book was released on 2009 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Yong Zhu
Publisher :
ISBN 13 :
Total Pages : 416 pages
Book Rating : 4.63/5 ( download)

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Download or read book The Study of the Role of Cyclin-dependent Kinase 5 (CDK5) During Cell Death written by Yong Zhu and published by . This book was released on 2002 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Lin Lin
Publisher :
ISBN 13 :
Total Pages : 470 pages
Book Rating : 4.18/5 ( download)

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Download or read book Regulation of Cyclin-dependent Kinase 5 (Cdk5) in Cell Death written by Lin Lin and published by . This book was released on 2003 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Amitabh Gupta
Publisher :
ISBN 13 :
Total Pages : 310 pages
Book Rating : 4.87/5 ( download)

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Download or read book Molecular and Cellular Mechanisms of the Cyclin-dependent Kinase 5 (Cdk5) in Neocortical Migration and Layer Formation written by Amitabh Gupta and published by . This book was released on 2004 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Petri Kerokoski
Publisher :
ISBN 13 : 9789512702145
Total Pages : 98 pages
Book Rating : 4.42/5 ( download)

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Download or read book Regulation of Cyclin-dependent Kinase 5 (cdk5) written by Petri Kerokoski and published by . This book was released on 2006 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Katelyn Rudisill
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.10/5 ( download)

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Download or read book Studying the Role of Cyclin Dependent Kinase 5 (Cdk5) in Maintaining Healthy Neuronal Functions in Class I Dendritic Aborization Neurons of Drosophila written by Katelyn Rudisill and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins constituting the Wnt signaling pathway--[gamma]-tubulin, Axin, Dsh, and Fz--regulate microtubule polarity in the dendrites of class I dendritic arborization (DA) neurons in Drosophila. Due to the distinct polarity of microtubules, microtubule motor proteins--dynein (minus end directed) and kinesin (plus end directed)--can ensure correct transport of cellular cargo within the cell. Within the dendrites, microtubule are oriented plus ends towards the cell body and minus ends directed away from the cell body. Previous studies indicate the Wnt proteins organize microtubule organization centers (MTOCs) to dendritic branch points in class I DA Drosophila neurons--this results in nucleation and maintenance of microtubules in the cell. Additionally, Cyclin Dependent Kinase 5 (Cdk5) exhibits important regulatory roles in neuronal cells. Given this, we aimed to study the role Cdk5 plays in regulating microtubule polarity in class I DA Drosophila neurons. We developed two alternate hypotheses to address our overarching question: H1) Cdk5 acts on proteins upstream of Axin within the Wnt signaling pathway or H2) Cdk5 acts directly on Axin through a parallel pathway outside of the Wnt pathway (Figure 4). Our experimental evidence showed depletion of Cdk5 in the cell resulted in decreased localization of [gamma]-tubulin to dendritic branch points, and mixed microtubule polarity in the cell. Exploration of the localization patterns of various proteins involved in localizing [gamma]-tubulin to dendritic branch points in class I DA Drosophila neurons--Axin, Dsh, APC2, and Fz--following knockdown of Cdk5 in the cells supports hypothesis 1: Cdk5 appears to act on proteins upstream of Axin within the Wnt signaling pathway. Furthermore, fluorescence microscopy experiments revealed Cdk5 localizing to the cell body of class I DA Drosophila neurons, which indicates Cdk5 could have other cellular functions, in addition to regulating microtubule dynamics.