Cooperativity Theory In Biochemistry

Author : T.L. Hill
Publisher : Springer Science & Business Media
ISBN 13 : 146125082X
Total Pages : 468 pages
Book Rating : 4.21/5 ( download)

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Download or read book Cooperativity Theory in Biochemistry written by T.L. Hill and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was trans mitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramatically different. We have an almost bewildering variety of information detailing many different aspects of life at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for rep licating, distributing and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromolecular nucleic acids and proteins, and the manner in which carbohydrates, lipids and smaller molecules work together to provide the molecular setting of living sys tems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of monographs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field. This will enable the reader to get a sense of historical perspective-what is known about the field today-and a description of the frontiers of research where our knowledge is increasing steadily.

Author : Terrell L. Hill
Publisher :
ISBN 13 : 9783540961031
Total Pages : 459 pages
Book Rating : 4.38/5 ( download)

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Download or read book Cooperativity Theory in Biochemistry written by Terrell L. Hill and published by . This book was released on 1985-01-01 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Arieh Y. Ben-Naim
Publisher : Springer Science & Business Media
ISBN 13 : 147573302X
Total Pages : 358 pages
Book Rating : 4.20/5 ( download)

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Download or read book Cooperativity and Regulation in Biochemical Processes written by Arieh Y. Ben-Naim and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book that attempts to study the origin of cooperatvity in binding systems from the molecular point of view. The molecular approach provides a deeper insight into the mechanism of cooperativity and regulation, than the traditional phenomenological approach. This book uses the tools of statistical mechanics to present the molecular theory of cooperativity. Cooperativity is used in a variety of processes-such as loading and unloading of oxygen at relatively small pressure differences; maintaining an almost constant concentration of various compounds in living cells; and switching on and off the reading of genetic information. This book may be used as a textbook by graduate students in Chemistry, Biochemistry and Biophysics, and will also be of interest to researchers in theoretical biochemistry.

Author : M. Weissbluth
Publisher : Springer Science & Business Media
ISBN 13 : 3642808018
Total Pages : 187 pages
Book Rating : 4.12/5 ( download)

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Download or read book Hemoglobin written by M. Weissbluth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approximately one third of the mass of a mammalian red blood cell is hemo globin. Its major function is to bind oxygen at the partial pressure prevailing in the lungs and to release it to the tissues where the partial pressure is lower. The process whereby hemoglobin performs this essential physiological role is characterized by a cooperative interaction among its constituent subunits. A great deal of research effort has been devoted to this interaction, going back at least as far as the fitst decade of this century. Moreover, cooperativity in hemo globin is probably not unique; it may well be one instance of a general class of interactions that occur in biological molecules. Certain enzymes with a variety of regulatory and catalytic functions, for example, contain several sites which interact in a highly specific manner such that the affinity of a given site for the substrate is markedly influenced by the state of binding at the other sites. But whereas we know very little of the structure of most enzymes of this type, hemo globin is one of a very small number of biological molecules whose immensely intricate machinery has been revealed to us. We owe this insight to the group under the leadership of M. F. PERUTZ in Cambridge, England, whose research over a period of several decades culminated in a detailed description of the three dimensional structure.

Author : A. Levitzki
Publisher : Springer Science & Business Media
ISBN 13 : 3642812317
Total Pages : 115 pages
Book Rating : 4.16/5 ( download)

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Download or read book Quantitative Aspects of Allosteric Mechanisms written by A. Levitzki and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this monograph is to summarize the essential features which characterize the behavior of regulatory systems. Firstly we discuss the laws which govern ligand binding in thermodynamic terms. The basic cooperative and allosteric phenomena are des cribed in thermodynamic terms without assuming any particular mo del. Then the molecular models developed by Monod, Wyman and Changeux and by Koshland, Nemethy and Filmer are presented in detail. Special emphasis has been given to the analysis of the Hill coefficient and its meaning both in thermodynamic terms and in terms of the two allosteric models: the concerted model of Monod, Wyman and Changeux and the sequential model of Koshland, Nemethy and Filmer. Special types of cooperativities are dis cussed in some detail namely, cooperativity stemming from ligand coupled protein association or dissociation, negative cooperati vity and half-of-the-sites reactivity. A slightly extended space was devoted to the discussion of negative cooperativity and half of-the-sites reactivity, since the existence of these phenomena and their possible biological importance is less of a common knowledge than positive cooperativity. This monograph does not attempt to be a review of specific examples analyzed according to one model or another. Rather, an attempt is made to provide the reader with the quantitative tools to analyze any specific regulatory system. Last but not least, I would like to thank Prof. F. W. Dahlquist from the Institute of Molecular Biology, the University of Oregon (Eugene) and Prof. D. E. Koshland, Jr.

Author : Jo M. Holt
Publisher : Elsevier
ISBN 13 : 0080497179
Total Pages : 315 pages
Book Rating : 4.74/5 ( download)

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Download or read book Energetics of Biological Macromolecules, Part D written by Jo M. Holt and published by Elsevier. This book was released on 2004-04-02 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed. *Methods for Evaluating Cooperativity in a Dimeric Hemoglobin*Multiple-Binding of Ligands to a Linear Biopolymer*Fluorescence Quenching Methods to Study Protein-Nucleic Acid Interactions*Linked Equilibria in Biotin Repressor Function: Thermodynamic, Structural and Kinetic Analysis

Author : Terrell L. Hill
Publisher : Springer Science & Business Media
ISBN 13 : 1461247365
Total Pages : 317 pages
Book Rating : 4.64/5 ( download)

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Download or read book Linear Aggregation Theory in Cell Biology written by Terrell L. Hill and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known ofthe chemical constitution of biological systems, the manner in which information was transmitted from one organism to another, or the extent to which the chemical basis oflife is unified. The picture today is dramatically different. We have an almost bewildering variety of information detailing many different aspects of life at the molecular level. These great advances have brought with them some breathtaking insights into the molecular mechanisms used by nature for replicating, distributing, and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromo lecular nucleic acids and proteins, and the manner in which carbohydrates, lipids, and smaller molecules work together to provide the molecular setting ofliving systems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context ofthis flood of information that this series of monographs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field. This will enable the reader to get a sense of historical perspective-what is known about the field today-and a descrip tion of the frontiers of research where our knowledge is increasing steadily.

Author : Arieh Ben-Naim
Publisher :
ISBN 13 : 9781475733037
Total Pages : 368 pages
Book Rating : 4.38/5 ( download)

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Download or read book Cooperativity and Regulation in Biochemical Processes written by Arieh Ben-Naim and published by . This book was released on 2014-01-15 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Sangdun Choi
Publisher : Springer Science & Business Media
ISBN 13 : 1597455318
Total Pages : 549 pages
Book Rating : 4.12/5 ( download)

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Download or read book Introduction to Systems Biology written by Sangdun Choi and published by Springer Science & Business Media. This book was released on 2008-05-17 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. The authors offer a broad overview of the field using key examples and typical approaches to experimental design. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches. The final sections provide ideas for theoretical and modeling optimization in systemic biological researches. The book is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642702031
Total Pages : 187 pages
Book Rating : 4.37/5 ( download)

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Download or read book Progress in Molecular and Subcellular Biology written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: