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Author : Dejan Djuric
Publisher : Cuvillier Verlag
ISBN 13 : 3867276439
Total Pages : 115 pages
Book Rating : 4.36/5 ( download)
Download or read book Continuous Granulation with a Twin-Screw Extruder written by Dejan Djuric and published by Cuvillier Verlag. This book was released on 2008 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Isaac Ghebre-Sellassie
Publisher : CRC Press
ISBN 13 : 1351129007
Total Pages : 464 pages
Book Rating : 4.08/5 ( download)
Download or read book Pharmaceutical Extrusion Technology written by Isaac Ghebre-Sellassie and published by CRC Press. This book was released on 2018-03-05 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Pharmaceutical Extrusion Technology, published in 2003, was deemed the seminal book on pharmaceutical extrusion. Now it is expanded and improved, just like the usage of extrusion has expanded, improved and evolved into an accepted manufacturing technology to continuously mix active pharmaceutical ingredients with excipients for a myriad of traditional and novel dosage forms. Pharmaceutical Extrusion Technology, Second Edition reflects how this has spawned numerous research activities, in addition to hardware and process advancements. It offers new authors, expanded chapters and contains all the extrusion related technical information necessary for the development, manufacturing, and marketing of pharmaceutical dosage forms. Key Features: Reviews how extrusion has become an accepted technology to continuously mix active pharmaceutical ingredients with excipients Focuses on equipment and process technology Explains various extrusion system configurations as a manufacturing methodology for a variety of dosage forms Presents new opportunities available only via extrusion and future trends Includes contributions of experts from the process and equipment fields
Author : Dennis Douroumis
Publisher : John Wiley & Sons
ISBN 13 : 1118307879
Total Pages : 404 pages
Book Rating : 4.78/5 ( download)
Download or read book Hot-Melt Extrusion written by Dennis Douroumis and published by John Wiley & Sons. This book was released on 2012-04-24 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusion twin screw extrusion techniques and practices in the laboratory and on production scale HME developments for the pharmaceutical industry solubility parameters for prediction of drug/polymer miscibility in HME formulations the influence of plasticizers in HME applications of polymethacrylate polymers in HME HME of ethylcellulose, hypromellose, and polyethylene oxide bioadhesion properties of polymeric films produced by HME taste masking using HME clinical studies, bioavailability and pharmacokinetics of HME products injection moulding and HME processing for pharmaceutical materials laminar dispersive & distributive mixing with dissolution and applications to HME technological considerations related to scale-up of HME processes devices and implant systems by HME an FDA perspective on HME product and process understanding improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here.
Author : Peter Kleinebudde
Publisher : John Wiley & Sons
ISBN 13 : 1119001323
Total Pages : 645 pages
Book Rating : 4.24/5 ( download)
Download or read book Continuous Manufacturing of Pharmaceuticals written by Peter Kleinebudde and published by John Wiley & Sons. This book was released on 2017-09-05 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.
Author : Klemens Kohlgrüber
Publisher : Carl Hanser Verlag GmbH Co KG
ISBN 13 : 3446433414
Total Pages : 370 pages
Book Rating : 4.10/5 ( download)
Download or read book Co-Rotating Twin-Screw Extruder written by Klemens Kohlgrüber and published by Carl Hanser Verlag GmbH Co KG. This book was released on 2012-11-12 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Co-rotating screws and/or extruders are used in many branches of industry for producing, preparing and/or processing highly viscous materials. They find a wide variety of applications especially in the plastics, rubber and food industries. Co-rotating twin-screw machines usually have modular configurations and are thus quite flexible for adapting to changing tasks and material properties. Well-founded knowledge of machines, processes and material behavior are required in order to design twin-screw extruder for economically successful operations. This book provides basic engineering knowledge regarding twin-screw machines; it lists the most important machine-technical requirements and provides examples based on actual practice. Better understanding of the processes is emphasized as this is a prerequisite for optimizing twin-screw designs and operating them efficiently. Besides basic functions, such as compounding, the book focuses on: - the historical development of twin-screws - the geometry of the screw elements (fundamentals, basic patents, patents overview) - material properties and material behavior in the machine - fundamentals of feed behavior, pressure build-up and power input - examples of applications for various processing tasks - compounding: tasks, applications, processing zones - potential and limits of modeling - scaling-up various processes - machine design incl. drives and materials
Author : Michael A. Repka
Publisher : Springer Science & Business Media
ISBN 13 : 1461484324
Total Pages : 472 pages
Book Rating : 4.25/5 ( download)
Download or read book Melt Extrusion written by Michael A. Repka and published by Springer Science & Business Media. This book was released on 2013-10-11 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with the basic principles and fundamentals of extrusion technology and a detailed description of the practical applications of a variety of extrusion processes, including various pharma grade extruders. In addition, the downstream production of films, pellets and tablets, for example, for oral and other delivery routes, are presented and discussed utilizing melt extrusion. This book is the first of its kind that discusses extensively the well-developed science of extrusion technology as applied to pharmaceutical drug product development and manufacturing. By covering a wide range of relevant topics, the text brings together all technical information necessary to develop and market pharmaceutical dosage forms that meet current quality and regulatory requirements. As extrusion technology continues to be refined further, usage of extruder systems and the array of applications will continue to expand, but the core technologies will remain the same.
Author : Günter Beyer
Publisher : John Wiley & Sons
ISBN 13 : 352734098X
Total Pages : 432 pages
Book Rating : 4.89/5 ( download)
Download or read book Reactive Extrusion written by Günter Beyer and published by John Wiley & Sons. This book was released on 2018-01-03 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive overview of reactive extrusion technology for over a decade combines the views of contributors from both academia and industry who share their experiences and highlight possible applications and markets. They also provide updated information on the underlying chemical and physical concepts, summarizing recent developments in terms of the material and machinery used. As a result, readers will find here a compilation of potential applications for reactive extrusion to access new and cost-effective polymeric materials, while using existing compounding machines.
Author : Harold F. Giles Jr
Publisher : William Andrew
ISBN 13 : 1437734820
Total Pages : 638 pages
Book Rating : 4.29/5 ( download)
Download or read book Extrusion written by Harold F. Giles Jr and published by William Andrew. This book was released on 2013-09-21 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Extrusion is designed to aid operators, engineers, and managers in extrusion processing in quickly answering practical day-to-day questions. The first part of the book provides the fundamental principles, for operators and engineers, of polymeric materials extrusion processing in single and twin screw extruders. The next section covers advanced topics including troubleshooting, auxiliary equipment, and coextrusion for operators, engineers, and managers. The final part provides applications case studies in key areas for engineers such as compounding, blown film, extrusion blow molding, coating, foam, and reprocessing. This practical guide to extrusion brings together both equipment and materials processing aspects. It covers basic and advanced topics, for reference and training, in thermoplastics processing in the extruder. Detailed reference data are provided on such important operating conditions as temperatures, start-up procedures, shear rates, pressure drops, and safety. A practical guide to the selection, design and optimization of extrusion processes and equipment Designed to improve production efficiency and product quality Focuses on practical fault analysis and troubleshooting techniques
Author : Isaac Ghebre-Selassie
Publisher : CRC Press
ISBN 13 : 0824755200
Total Pages : 383 pages
Book Rating : 4.01/5 ( download)
Download or read book Pharmaceutical Extrusion Technology written by Isaac Ghebre-Selassie and published by CRC Press. This book was released on 2003-05-14 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Extrusion Technology is the only resource to provide in-depth descriptions and analyses of the key parameters of extruders and extrusion processes. The book highlights the applicability of melt extrusion in pharmaceutical drug development and product manufacturing, including controlled release, dissolution rate and bioavailability enhancement, and granulation technology. It brings together the technical information necessary to develop and market pharmaceutical dosage forms that meet current quality and regulatory requirements and details extruder hardware and controls, process definition and troubleshooting of single and twin screw extrusion processes, and more.
Author : Isaac Ghebre-Sellassie
Publisher : CRC Press
ISBN 13 : 1498704921
Total Pages : 433 pages
Book Rating : 4.22/5 ( download)
Download or read book Pharmaceutical Extrusion Technology written by Isaac Ghebre-Sellassie and published by CRC Press. This book was released on 2018-03-05 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Pharmaceutical Extrusion Technology, published in 2003, was deemed the seminal book on pharmaceutical extrusion. Now it is expanded and improved, just like the usage of extrusion has expanded, improved and evolved into an accepted manufacturing technology to continuously mix active pharmaceutical ingredients with excipients for a myriad of traditional and novel dosage forms. Pharmaceutical Extrusion Technology, Second Edition reflects how this has spawned numerous research activities, in addition to hardware and process advancements. It offers new authors, expanded chapters and contains all the extrusion related technical information necessary for the development, manufacturing, and marketing of pharmaceutical dosage forms. Key Features: Reviews how extrusion has become an accepted technology to continuously mix active pharmaceutical ingredients with excipients Focuses on equipment and process technology Explains various extrusion system configurations as a manufacturing methodology for a variety of dosage forms Presents new opportunities available only via extrusion and future trends Includes contributions of experts from the process and equipment fields
