Conformational Proteomics Of Macromolecular Architecture

Author : R Holland Cheng
Publisher : World Scientific
ISBN 13 : 9814483966
Total Pages : 433 pages
Book Rating : 4.64/5 ( download)

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Download or read book Conformational Proteomics Of Macromolecular Architecture: Approaching The Structure Of Large Molecular Assemblies And Their Mechanisms Of Action (With Cd-rom) written by R Holland Cheng and published by World Scientific. This book was released on 2004-06-21 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological processes involving large macromolecular assemblies are thought to be a dynamic consequence of cooperativity and metastability. The folding of a peptide chain creates local environments from which “activity” can emerge. In the same way, the assembly of large molecular complexes creates dynamic features that would only be feasible in a large construct. The biological implications of such adaptation are explored as it applies to the static quasisymmetry situations, as well as to the dynamics of structural transitions. The current wealth of solved high-resolution complex structures makes this an appropriate time to summarize the state of the art in structural dynamics of living architectures. With contributions by leading scientists in the fields of virology, bacterial flagellum, cytoskeleton, ribosome and giant enzymes, this important book presents cutting-edge knowledge in the various fields of structural proteomics of very large molecular assemblies, with the focus on their mechanisms of action.

Author : R. Holland Cheng
Publisher : World Scientific
ISBN 13 : 9789812386151
Total Pages : 440 pages
Book Rating : 4.57/5 ( download)

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Download or read book Conformational Proteomics of Macromolecular Architecture written by R. Holland Cheng and published by World Scientific. This book was released on 2004 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electronic version of the text of the same title with additional audio and video links.

Author :
Publisher :
ISBN 13 :
Total Pages : 1576 pages
Book Rating : 4.35/5 ( download)

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Download or read book Environmental Health Perspectives written by and published by . This book was released on 2004 with total page 1576 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Vladimir Uversky
Publisher : John Wiley & Sons
ISBN 13 : 0470618310
Total Pages : 532 pages
Book Rating : 4.18/5 ( download)

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Download or read book Flexible Viruses written by Vladimir Uversky and published by John Wiley & Sons. This book was released on 2012-02-07 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.

Author : Gregory J. Morgan
Publisher : JHU Press
ISBN 13 : 142144402X
Total Pages : 388 pages
Book Rating : 4.24/5 ( download)

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Download or read book Cancer Virus Hunters written by Gregory J. Morgan and published by JHU Press. This book was released on 2022-08-02 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traces the history of the study of tumor viruses and its role in driving breakthroughs in cancer research. Worldwide, approximately one-fifth of human cancers are caused by tumor viruses, with hepatitis B virus and HPV being the leading culprits. While the explosive growth in molecular biology in the late twentieth century is well known, the role that the study of tumor viruses has played in driving many of the greatest breakthroughs is not. Without the insights gained by studying tumor viruses, many significant theoretical advancements over the last four decades in cellular and molecular biology would not have been made. More practically, the study of tumor viruses has saved thousands, if not millions, of lives. In Cancer Virus Hunters, Gregory J. Morgan traces the high points in the development of tumor virology, from Peyton Rous's pioneering work on chicken tumors in 1909 to the successful development of an HPV vaccine for cervical cancer in 2006. Morgan offers a novel approach to understanding the interconnectedness of a long series of biomedical breakthroughs, including those that led to seven Nobel prizes. Among other advances, Morgan describes and contextualizes the science that prompted the discoveries of reverse transcriptase, RNA splicing, the tumor suppressor p53, the vaccine for hepatitis B, and the HIV test. He also explores how "cancer virus hunters" have demonstrated the virtue of beginning with a simple system, even when investigating a complex disease like cancer. Based on extensive archival research and over fifty interviews with experts, Cancer Virus Hunters is a tour de force summarizing a century of research to show how discoveries made with tumor viruses came to dominate the contemporary understanding of cancer. By showcasing the scientists themselves, the book makes for an unusually accessible journey through the history of science. It will be of interest to biomedical professionals—especially in oncology, hepatology, and infectious disease—in addition to historians of science and anyone interested in cancer research.

Author : Joachim Frank
Publisher : CRC Press
ISBN 13 : 1000989445
Total Pages : 553 pages
Book Rating : 4.41/5 ( download)

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Download or read book Novel Developments in Cryo‐EM of Biological Molecules written by Joachim Frank and published by CRC Press. This book was released on 2023-10-06 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cryo-EM, as it is currently practiced in many laboratories, is limited to the visualization of molecules that are in thermal equilibrium at the time before freezing. A further limitation is that the existing software does not fully exploit the information that is contained in the images of large ensembles of molecules in thermal equilibrium. This book is a collection of recent articles by the author, reprinted with introductions, and they mainly describe two novel methods in cryo-EM, one computational and the other experimental that requires the use of a microfluidic device. Both methods have the capacity to shed light on the dynamic behavior of biomolecules. Combined, they greatly expand the range of applications of cryo-EM. The book describes a successful approach in which, based on cryo-EM data, all states visited by the molecule in thermal equilibrium are mapped by manifold embedding—a method of geometric machine learning—and the energy landscape of the molecule is derived. It also discusses methods and biological results of time-resolved cryo-EM, following a reaction in a non-equilibrium system over a short period of time and resulting in the capture of short-lived states that have been inaccessible by standard methods of cryo-EM.

Author : MacLennan, Bruce
Publisher : IGI Global
ISBN 13 : 1609601882
Total Pages : 392 pages
Book Rating : 4.81/5 ( download)

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Download or read book Theoretical and Technological Advancements in Nanotechnology and Molecular Computation: Interdisciplinary Gains written by MacLennan, Bruce and published by IGI Global. This book was released on 2010-11-30 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theoretical and Technological Advancements in Nanotechnology and Molecular Computation: Interdisciplinary Gains compiles research in areas where nanoscience and computer science meet. This book explores current and future trends that discus areas such as, cellular nanocomputers, DNA self-assembly, and the architectural design of a "nano-brain." The authors of each chapter have provided in-depth insight into the current state of research in nanotechnology and molecular computation as well as identified successful approaches, tools and methodologies in their research.

Author : Management Association, Information Resources
Publisher : IGI Global
ISBN 13 : 1466651261
Total Pages : 1654 pages
Book Rating : 4.65/5 ( download)

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Download or read book Nanotechnology: Concepts, Methodologies, Tools, and Applications written by Management Association, Information Resources and published by IGI Global. This book was released on 2014-02-28 with total page 1654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few decades, devices and technologies have been significantly miniaturized from one generation to the next, providing far more potential in a much smaller package. The smallest of these recently developed tools are miniscule enough to be invisible to the naked eye. Nanotechnology: Concepts, Methodologies, Tools, and Applications describes some of the latest advances in microscopic technologies in fields as diverse as biochemistry, materials science, medicine, and electronics. Through its investigation of theories, applications, and new developments in the nanotechnology field, this impressive reference source will serve as a valuable tool for researchers, engineers, academics, and students alike.

Author : Anthony J.F. Griffiths
Publisher : Macmillan
ISBN 13 : 9780716749394
Total Pages : 808 pages
Book Rating : 4.94/5 ( download)

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Download or read book An Introduction to Genetic Analysis written by Anthony J.F. Griffiths and published by Macmillan. This book was released on 2005 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eighth edition of 'An Introduction to Genetic Analysis' has been extensively revised, shaping its coverage to match current research and thinking in genetics.

Author : J. Robin Harris
Publisher : Springer Nature
ISBN 13 : 3030589714
Total Pages : 580 pages
Book Rating : 4.14/5 ( download)

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Download or read book Macromolecular Protein Complexes III: Structure and Function written by J. Robin Harris and published by Springer Nature. This book was released on 2020-11-30 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.