Computational Chemotaxis Models For Neurodegenerative Disease

Author : William E Schiesser
Publisher : World Scientific Publishing Company
ISBN 13 : 9813207477
Total Pages : 172 pages
Book Rating : 4.79/5 ( download)

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Download or read book Computational Chemotaxis Models for Neurodegenerative Disease written by William E Schiesser and published by World Scientific Publishing Company. This book was released on 2017-02-24 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mathematical model presented in this book, based on partial differential equations (PDEs) describing attractant-repellent chemotaxis, is offered for a quantitative analysis of neurodegenerative disease (ND), e.g., Alzheimer's disease (AD). The model is a representation of basic phenomena (mechanisms) for diffusive transport and biochemical kinetics that provides the spatiotemporal distribution of components which could explain the evolution of ND, and is offered with the intended purpose of providing a small step toward the understanding, and possible treatment of ND. The format and emphasis of the presentation is based on the following elements: A statement of the PDE system, including initial conditions (ICs), boundary conditions (BCs) and the model parameters.Algorithms for the calculation of numerical solutions of the PDE system with a minimum of mathematical formality.A set of R routines for the calculation of numerical solutions, including a detailed explanation of all of the sections of the code. The R routines can be executed after a straightforward download of R, an open-source scientific computing system available from the Internet.Presentation of the numerical solutions, particularly in graphical (plotted) format to enhance the visualization of the solution.Summary and conclusions concerning the principal results from the model that might serve as the basis for a next step in the modeling of ND. In other words, a methodology for numerical PDE modeling is presented that is flexible, open ended and readily implemented on modest computers. If the reader is interested in an alternate model, it might possibly be implemented by: (1) modifying and/or extending the current model (for example, by adding terms to the PDEs or adding additional PDEs), or (2) using the reported routines as a prototype for the model of interest. These suggestions illustrate an important feature of computer-based modeling, that is, the readily available procedure of numerically experimenting with a model. The current model is offered as only a first step toward the resolution of this urgent medical problem. Request Inspection Copy

Author : W. E. Schiesser
Publisher :
ISBN 13 : 9789813207462
Total Pages : pages
Book Rating : 4.69/5 ( download)

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Download or read book Computational Chemotaxis Models for Neurodegenerative Disease written by W. E. Schiesser and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

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Publisher :
ISBN 13 :
Total Pages : 576 pages
Book Rating : 4.68/5 ( download)

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Download or read book Journal of the Royal Society, Interface written by and published by . This book was released on 2005 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : John H. Byrne
Publisher : Oxford University Press
ISBN 13 : 0190456787
Total Pages : 608 pages
Book Rating : 4.88/5 ( download)

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Download or read book The Oxford Handbook of Invertebrate Neurobiology written by John H. Byrne and published by Oxford University Press. This book was released on 2019-01-29 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Invertebrates have proven to be extremely useful model systems for gaining insights into the neural and molecular mechanisms of sensory processing, motor control and higher functions such as feeding behavior, learning and memory, navigation, and social behavior. A major factor in their enormous contributions to neuroscience is the relative simplicity of invertebrate nervous systems. In addition, some invertebrates, primarily the molluscs, have large cells, which allow analyses to take place at the level of individually identified neurons. Individual neurons can be surgically removed and assayed for expression of membrane channels, levels of second messengers, protein phosphorylation, and RNA and protein synthesis. Moreover, peptides and nucleotides can be injected into individual neurons. Other invertebrate model systems such as Drosophila and Caenorhabditis elegans offer tremendous advantages for obtaining insights into the neuronal bases of behavior through the application of genetic approaches. The Oxford Handbook of Invertebrate Neurobiology reviews the many neurobiological principles that have emerged from invertebrate analyses, such as motor pattern generation, mechanisms of synaptic transmission, and learning and memory. It also covers general features of the neurobiology of invertebrate circadian rhythms, development, and regeneration and reproduction. Some neurobiological phenomena are species-specific and diverse, especially in the domain of the neuronal control of locomotion and camouflage. Thus, separate chapters are provided on the control of swimming in annelids, crustaea and molluscs, locomotion in hexapods, and camouflage in cephalopods. Unique features of the handbook include chapters that review social behavior and intentionality in invertebrates. A chapter is devoted to summarizing past contributions of invertebrates to the understanding of nervous systems and identifying areas for future studies that will continue to advance that understanding.

Author : Yuen-Cheng Fung
Publisher : World Scientific Publishing Company
ISBN 13 : 9789814713641
Total Pages : 838 pages
Book Rating : 4.43/5 ( download)

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Download or read book Classical and Computational Solid Mechanics written by Yuen-Cheng Fung and published by World Scientific Publishing Company. This book was released on 2016-11-30 with total page 838 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition provides an update of the recent developments in classical and computational solid mechanics. The structure of the book is also updated to include five new areas: Fundamental Principles of Thermodynamics and Coupled Thermoelastic Constitutive Equations at Large Deformations, Functional Thermodynamics and Thermoviscoelasticity, Thermodynamics with Internal State Variables and Thermo-Elasto-Viscoplasticity, Electro-Thermo-Viscoelasticity/Viscoplasticity, and Meshless Method. These new topics are added as self-contained sections or chapters. Many books in the market do not cover these topics. This invaluable book has been written for engineers and engineering scientists in a style that is readable, precise, concise, and practical. It gives the first priority to the formulation of problems, presenting the classical results as the gold standard, and the numerical approach as a tool for obtaining solutions.

Author : Sumeet Dua
Publisher : World Scientific
ISBN 13 : 9814340294
Total Pages : 467 pages
Book Rating : 4.98/5 ( download)

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Download or read book Computational Analysis of the Human Eye with Applications written by Sumeet Dua and published by World Scientific. This book was released on 2011 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in semi-automated high-throughput image data collection routines, coupled with a decline in storage costs and an increase in high-performance computing solutions have led to an exponential surge in data collected by biomedical scientists and medical practitioners. Interpreting this raw data is a challenging task, and nowhere is this more evident than in the field of opthalmology. The sheer speed at which data on cataracts, diabetic retinopathy, glaucoma and other eye disorders are collected, makes it impossible for the human observer to directly monitor subtle, yet critical details. This book is a novel and well-timed endeavor to present, in an amalgamated format, computational image modeling methods as applied to various extrinsic scientific problems in ophthalmology. It is self-contained and presents a highly comprehensive array of image modeling algorithms and methodologies relevant to ophthalmologic problems. The book is the first of its kind, bringing eye imaging and multi-dimensional hyperspectral imaging and data fusion of the human eye, into focus. The editors are at the top of their fields and bring a strong multidisciplinary synergy to this visionary volume. Their "inverted-pyramid" approach in presenting the content, and focus on core applications, will appeal to students and practitioners in the field.

Author : Charles J. Epstein
Publisher : Oxford University Press, USA
ISBN 13 : 019514502X
Total Pages : 1110 pages
Book Rating : 4.21/5 ( download)

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Download or read book Inborn Errors of Development written by Charles J. Epstein and published by Oxford University Press, USA. This book was released on 2004 with total page 1110 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.

Author : Khawaja Husnain Haider
Publisher : Springer Nature
ISBN 13 : 9811926557
Total Pages : 1527 pages
Book Rating : 4.56/5 ( download)

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Download or read book Handbook of Stem Cell Therapy written by Khawaja Husnain Haider and published by Springer Nature. This book was released on 2022-11-07 with total page 1527 pages. Available in PDF, EPUB and Kindle. Book excerpt: The handbook comprehensively reviews the therapeutic potential of stem cells and stem cell secretome-based cell-free strategies in regenerative medicine. The chapters in section I and section II respectively discuss the diverse applications of mesenchymal stem cells and non- mesenchymal stem cells, including skeletal myoblasts, endothelial progenitor cells, adipose tissue-derived stem cells, induced pluripotent stem cells, and neuronal stem cells in myocardial repair, inflammatory bowel disease, cognitive deficits, wound healing, retinal disorders, and COVID-19. The subsequent chapters in section IIIprimarily focused on the fast-emerging cell-free therapy approach in regenerative medicine for tissue repair and regeneration. These chapters review the impact of stem cell-derived secretome on various biological processes such as angiogenesis, neurogenesis, tissue repair, immunomodulation, musculoskeletal pathologies, wound healing, anti-fibrotic, and anti-tumorigenesis for tissue maintenance and regeneration.Lastly, section IV summarizes miscellaneous aspects of cell-based therapy, includingthe treatment advantages, opportunities, and shortcomings in stem cell-based therapy, potentially helping to refine future studies and translate them from experimental to clinical studies. Moreover, this section also has chapters on cancer stem cells as novel targets in cancer therapeutics. This Major Reference Book (MRW) is a valuable resource for researchers involved in stem cell research to understand the multifaceted therapeutic applications of stem cells and their derivative secretome in regenerative medicine.​

Author : Amal Kumar Dhara
Publisher : Springer Nature
ISBN 13 : 9819977037
Total Pages : 637 pages
Book Rating : 4.31/5 ( download)

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Download or read book Role of Herbal Medicines written by Amal Kumar Dhara and published by Springer Nature. This book was released on with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Lee A. Segel
Publisher : Cambridge University Press
ISBN 13 : 9780521274777
Total Pages : 326 pages
Book Rating : 4.7X/5 ( download)

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Download or read book Modeling Dynamic Phenomena in Molecular and Cellular Biology written by Lee A. Segel and published by Cambridge University Press. This book was released on 1984-03-30 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dynamic development of various processes is a central problem of biology and indeed of all the sciences. The mathematics describing that development is, in general, complicated, because the models that are realistic are usually nonlinear. Consequently many biologists may not notice a possible application of theory. They may be unable to decide whether a particular model captures the essence of a system, or to appreciate that analysis of a model can reveal important aspects of biological problems and may even describe in detail how a system works. The aim of this textbook is to remedy the situation by adopting a general approach to model analysis and applying it several times to problems (drawn primarily from molecular and cellular biology) of gradually increasing biological and mathematical complexity. Although material of considerable sophistication is included, little mathematical background is required - only some exposure to elementary calculus; appendixes supply the necessary mathematics and the author concentrates on concepts rather than techniques. He also emphasizes the role of computers in giving a full picture of model behavior and complementing more qualitative analysis. Some problems suitable for computer analysis are also included. This is a class-tested textbook suitable for a one-semester course for advanced undergraduate and beginning graduate students in biology or applied mathematics. It can also be used as a source book for teachers and a reference for specialists.