Characterization Of The Mechanism Of Oxidation Of Ng Hydroxy L Arginine By Macrophage Nitric Oxide Synthase

Author : Robert Allen Pufahl
Publisher :
ISBN 13 :
Total Pages : 358 pages
Book Rating : 4.34/5 ( download)

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Download or read book Characterization of the Mechanism of Oxidation of NG̲-Hydroxy-L-Arginine by Macrophage Nitric Oxide Synthase written by Robert Allen Pufahl and published by . This book was released on 1994 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Yann A. Henry
Publisher : Springer Science & Business Media
ISBN 13 : 1461311853
Total Pages : 343 pages
Book Rating : 4.50/5 ( download)

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Download or read book Nitric Oxide Research from Chemistry to Biology: EPR Spectroscopy of Nitrosylated Compounds written by Yann A. Henry and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : M. A Titheradge
Publisher : Springer Science & Business Media
ISBN 13 : 1592597491
Total Pages : 321 pages
Book Rating : 4.99/5 ( download)

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Download or read book Nitric Oxide Protocols written by M. A Titheradge and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Michael Titheradge provides both the experienced researcher and the newcomer with time-tested techniques to cover all aspects of NO synthase and metabolism. Topics range from the cloning and expression of the different isoforms of NO synthase to the role of NO in DNA damage and apoptosis and include indirect and direct measurements of NO production, measurement on NO synthase mRNA both in situ and in vitro, and Western blotting and immunohistochemical localization of different isoforms of NO synthase. A variety of alternative techniques are described to enable researchers to set up an assay using either the simplest equipment or the most expensive EPR machines.

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 370916351X
Total Pages : 221 pages
Book Rating : 4.11/5 ( download)

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Download or read book Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to make further progress in elucidating the mechanism of NOS catalysis it will be essential to throw light on the interaction between the enzyme and its substrate. An understanding of the catalytic site will also assist the development of therapeutically important NOS inhibitors. In particular. it will be useful to uncover any differences that exist between the substrate binding sites of the three NOS isozymes which might be exploited for the development of isoform selective NOS inhibitors. A comparison of NOS to other Arg-binding proteins has shown no significant sequence homology (159). Moreover, the lack of a 3D structure and absence of significant sequence homology between the NOS oxygenase domain and known cytochromes P450 has made it difficult to identify residues and construct a model of the distal heme pocket responsible for substrate binding. However, a number of groups are currently working towards crystallisation of the separate NOS reductase and oxygenase domains of the three isoforms for X-ray diffraction studies; the first X-ray structure is likely to be forthcoming within a matter of months. * The results of these studies are expected to resolve many of the uncertainties surrounding the structure of the NOS catalytic site. Preliminary X-ray diffraction analysis of CPR from rat liver has already been reported by MASTERS et al. (524) and the future emergence of a detailed structure for this protein should throw light on the structure and function of the NOS reductase domain.

Author :
Publisher :
ISBN 13 :
Total Pages : 1840 pages
Book Rating : 4.82/5 ( download)

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Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1840 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Gabor M. Rubanyi
Publisher : CRC Press
ISBN 13 : 0203303725
Total Pages : 378 pages
Book Rating : 4.26/5 ( download)

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Download or read book Pathophysiology and Clinical Applications of Nitric Oxide written by Gabor M. Rubanyi and published by CRC Press. This book was released on 2003-09-02 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems. A number of the fundamental research observations are now being developed into therapeutic principles and these are being pursued through clinical trials. This is the first work summarizing, in its two volumes, the quantum leap from basic science to clinical applications emerging from this decade of research.

Author : Kimberly Ann White
Publisher :
ISBN 13 :
Total Pages : 270 pages
Book Rating : 4.17/5 ( download)

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Download or read book Studies of the Heme Environment and Electron Flow in the Inducible Murine Macrophage Nitric Oxide Synthase written by Kimberly Ann White and published by . This book was released on 1994 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : N. Allon
Publisher : Springer Science & Business Media
ISBN 13 : 1461519039
Total Pages : 250 pages
Book Rating : 4.34/5 ( download)

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Download or read book Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide written by N. Allon and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: A decade ago, for most scientists investigating various issues in life sciences the word "NO" was used in a negative context. It is astounding to observe how recently researchers are addressing the issue of NO, namely, nitric oxide, in over fifty publications weekly. Science journal, while naming nitric oxide: "Molecule of the Year" (December 1992), said it all: "NO news is good news. " For a long period of time NO was considered as a pollutant and every ecology minded person tried to eliminate it. It was the discovery of NO involvement in the process of host killing by macrophages and several years later the finding that EDRF is none else but NO, that promoted this field. Nitric oxide's major role in the control of blood pressure is merely one factor of an extensive list of effects and functions attributed to it. NO is implicated in long-term potentiation (LPT), a principal process involved in memory consolidation and it is considered as the main biochemical substance responsible for penile erection. It should be noted that additional roles for NO are discovered continuously as many laboratories join the quest for the mystery of this small molecule. The observation that NO is involved in various biological processes is not unique, as other second messengers (i. e. , cyclic AMP), participate in a diverse set of functions.

Author :
Publisher :
ISBN 13 :
Total Pages : 778 pages
Book Rating : 4.10/5 ( download)

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Download or read book Dissertation Abstracts International written by and published by . This book was released on 1995 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Louis J. Ignarro
Publisher : Academic Press
ISBN 13 : 9780080525037
Total Pages : 1017 pages
Book Rating : 4.32/5 ( download)

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Download or read book Nitric Oxide written by Louis J. Ignarro and published by Academic Press. This book was released on 2000-09-13 with total page 1017 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense