Cellular And Molecular Biology Of Intermediate Filaments

Author : R.D. Goldman
Publisher : Springer Science & Business Media
ISBN 13 : 1475796048
Total Pages : 483 pages
Book Rating : 4.49/5 ( download)

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Download or read book Cellular and Molecular Biology of Intermediate Filaments written by R.D. Goldman and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research activity on intermediate filaments (IF) has increased dramatically over the past decade. For the most part, this surge of interest is due to their identification as ubiquitous constituents of the cytoskeleton and karyoskeleton (nuclear matrix) of eukaryotic cells and the fact that we know very little regarding their functions. In sharp contrast to the other major cytoskeletal systems, microfilaments and microtubules, IF exhibit a high degree of heterogeneity with regard to their protein subunit composition. Indeed, one can only marvel at the number of different IF polypeptides, their associated proteins (IFAP) and, consequently, the number of genes involved in encoding the multiple constituents of the various IF networks found in different cell types. The chapters in this book demonstrate how various experimental approaches involv ing cellular, molecular, biochemical, and immunological methods have been utilized to generate information regarding the structure and function of IF. To this end, we have gathered together chapters from experts in the major fields of IF research. In each chapter, the authors have combined reviews of the available scientific literature with their own ideas on current and future directions for IF research. The chapters have been divided into five major sections which are concerned with the subcellular organization of IF, the molecular structure of IF, the differential expression of IF genes, descriptions of associ ated proteins involved in the intracellular organization of IF, and finally an analysis of the changes seen in IF in pathological conditions.

Author :
Publisher : Academic Press
ISBN 13 : 0128034912
Total Pages : 857 pages
Book Rating : 4.10/5 ( download)

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Download or read book Intermediate Filament Proteins written by and published by Academic Press. This book was released on 2016-01-18 with total page 857 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intermediate Filament Proteins, the latest volume in the Methods in Enzymology series covers all the intermediate filaments in vertebrates and invertebrates, providing a unique understanding of the multiple different tissue-specific intermediate filaments. This volume also covers the latest methods that are currently being used to study intermediate filament protein function and dynamics. It will be an important companion for any experimentalist interesting in studying this protein family in their cell or organism model system. Focuses on intermediate filaments, including the latest information Provides an up-to-date understanding of the field Contains contributions from the major scientists working and publishing in the field

Author : M. Bishr Omary
Publisher : Gulf Professional Publishing
ISBN 13 : 9780125641739
Total Pages : 966 pages
Book Rating : 4.37/5 ( download)

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Download or read book Intermediate Filament Cytoskeleton written by M. Bishr Omary and published by Gulf Professional Publishing. This book was released on 2004-12-02 with total page 966 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intermediate filaments are a large family of proteins that are the cytoskeletal elements involved in a number of skin, liver, neuromuscular, cardiac, eye and hair diseases. Intermediate filament genes are regulated in a tissue-and cell type-specific manner and their polymerized protein products protects the cells and tissue they are part of against a variety of mechanical and nonmechanical stresses. This book provides a comprehensive resource of methodology essentials, describing a variety of essential tools and assays for studying intermediate filaments. The book provides user-friendly advice and protocols covering all aspects of intermediate filaments including protein isolation and structure, protein and gene regulation, relationship to disease and apoptosis, and associated proteins. Both mammalian and non-mammalian systems and animal models are covered, making this book a must-have for any investigator wishing to study IF genes or their protein products. * Covers intermediate filaments from crystallography, protein chemistry, cell and molecular biology, microrheology, gene regulation, to animal models and human disease * Practical and user-friendly with detailed "how-to-protocols and "tricks of the trade" * Includes detailed tables of useful reagents, vendors and web links

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.81/5 ( download)

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Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author :
Publisher : Academic Press
ISBN 13 : 0128034904
Total Pages : 628 pages
Book Rating : 4.03/5 ( download)

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Download or read book Intermediate Filament Associated Proteins written by and published by Academic Press. This book was released on 2016-01-14 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intermediate Filament Associated Proteins, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in intermediate filament associated proteins and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in intermediate filament associated proteins and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers

Author : Jesus Paramio
Publisher : Springer Science & Business Media
ISBN 13 : 0387337814
Total Pages : 158 pages
Book Rating : 4.14/5 ( download)

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Download or read book Intermediate Filaments written by Jesus Paramio and published by Springer Science & Business Media. This book was released on 2007-06-07 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.

Author : P. Traub
Publisher : Springer Science & Business Media
ISBN 13 : 3642702309
Total Pages : 276 pages
Book Rating : 4.03/5 ( download)

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Download or read book Intermediate Filaments written by P. Traub and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on cytoskeletal elements of eukaryotic cells has been expand ing explosively during the past 5 to 10 years. Due largely to the employment of electron and immunofluorescent microscopy, significant results have been obtained which have provided interesting new insights into the dynamics of nucleated cells at the structural, physiological, as well as developmental levels. While a substantial amount of knowledge has accumulated on the function of microfilaments and microtubules, the roles of the third major class of cytoskeletal structures in vertebrate cells, the intermediate filaments, have largely resisted clarification. The investigation of cultured cells and of tissues from various developmental stages has furnished a host of information on the inter-and intracellular distribution of the different types of intermediate filaments and led to the contention that they have a structural and organizing function in the cytoplasm of vertebrate cells. However, the results of recent experimen that vertebrate cells can function perfectly in the tation have shown complete absence of cytoplasmically extended intermediate filament meshworks. It is legitimate to suppose, therefore, that their function in vertebrate cells is much more subtle and complex than generally presumed. Our interest in the structure and function of intermediate filament proteins was initiated approximately 7 years ago while working on the regulation of macromolecular synthesis in picornavirus-infected mam malian cells. In attempts to demonstrate virus-induced changes in the nuclear protein components of the host cells, the nonionic detergent extraction method was used to purify nuclei.

Author : Eric Wong
Publisher : Axolotl Academic Publishing
ISBN 13 : 0985226110
Total Pages : 283 pages
Book Rating : 4.14/5 ( download)

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Download or read book Cells: Molecules and Mechanisms written by Eric Wong and published by Axolotl Academic Publishing. This book was released on 2009 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.

Author : J.W. Shay
Publisher : Springer Science & Business Media
ISBN 13 : 1461321514
Total Pages : 349 pages
Book Rating : 4.14/5 ( download)

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Download or read book Cell and Molecular Biology of the Cytoskeleton written by J.W. Shay and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Harald Herrmann
Publisher : Springer Science & Business Media
ISBN 13 : 9780306458545
Total Pages : 660 pages
Book Rating : 4.43/5 ( download)

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Download or read book Intermediate Filaments written by Harald Herrmann and published by Springer Science & Business Media. This book was released on 1998-09-30 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprises 20 contributions on intermediate filament (IF) proteins, providing a comprehensive overview of the essentials of IF research and very recent developments, including many previously unpublished concepts and results. Representative topics include intermediate filament organization during oogenesis and early development in the clawed frog, lessons from keratin transgenic and knockout mice, cytokeratins as markers of differentiation in the diagnosis of epithelial tumors, vimentin and lipid metabolism, and nuclear lamin- binding proteins. Annotation copyrighted by Book News, Inc., Portland, OR