Cardiovascular Genomics New Pathophysiological Concepts

Author : P.A.F.M. Doevendans
Publisher : Springer Science & Business Media
ISBN 13 : 1461510058
Total Pages : 306 pages
Book Rating : 4.55/5 ( download)

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Download or read book Cardiovascular Genomics: New Pathophysiological Concepts written by P.A.F.M. Doevendans and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Four years ago-in December 1997-the first European Science Foundation Workshop on Cardiovascular Specific Gene Expression was held in Maastricht. It was hardly possible to imagine the progress in the field in those four years. In 1997, gene expression was still an art focused on individual genes; in 200 I, many labs have access to micro-array facilities to determine the expression of thousands of genes simultaneously. In 1997, gene expression was an area of fundamental research in basis molecular biology laboratories; in 200 I, clinical cardiovascular research has incorporated gene expression approaches. In 1997, the interpretation of a gene expression experiment was usually straightforward; in 200 I, advanced bioinformatics tools are needed to approach the extreme complexities of genetic control of cell and tissue function. The second symposium in this series is focused on Cardiovascular Genomics. New Pathophysiological Concepts. The organizing committee chose to invite a group of renown scientists and young investigators around four topics of eminent importance in cardiovascular research. These topics reflect the major present-day clinical cardiovascular problems: atherosclerosis, hypertension, arrhythmias and heart failure. In addition to these four disease-driven topics, the workshop has sessions on gene expression methodologies and cellular transplant approaches to cardiovascular disease.

Author : Richard E. Klabunde
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975150090
Total Pages : 689 pages
Book Rating : 4.99/5 ( download)

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Download or read book Cardiovascular Physiology Concepts written by Richard E. Klabunde and published by Lippincott Williams & Wilkins. This book was released on 2020-12-01 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praised for its concise coverage, this highly accessible monograph lays a foundation for understanding the underlying concepts of normal cardiovascular function and offers a welcome alternative to a more mechanistically oriented approach or an encyclopedic physiology text. Clear explanations, ample illustrations and engaging clinical cases and problems provide the perfect guidance for self-directed learning and prepare you to excel in clinical practice.

Author : Thomas H. Marwick
Publisher : Springer Science & Business Media
ISBN 13 : 1461503310
Total Pages : 261 pages
Book Rating : 4.16/5 ( download)

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Download or read book Stress Echocardiography written by Thomas H. Marwick and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress Echocardiography - Its Role in the Diagnosis and Evaluation of Coronary Artery Disease - Second Edition by Thomas Marwick is a concise, practical guide for anyone new to the field of stress echocardiography or an excellent summary of the existing evidence base for the experienced user. Dr. W.F. Armstrong described the first edition of this book in his Foreword to the first edition as "a thorough, comprehensive review of the basic and advanced concepts of stress echocardiography. This text represents an excellent starting point for individuals wishing to gain initial familiarity with stress echocardiography and a superb reference source for more experienced investigators and clinicians finding a need to further develop their understanding of the technique and advance its clinical relevance in their laboratories."

Author : Martial G. Bourassa
Publisher : Springer Science & Business Media
ISBN 13 : 9780387295527
Total Pages : 520 pages
Book Rating : 4.26/5 ( download)

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Download or read book Antioxidants and Cardiovascular Disease written by Martial G. Bourassa and published by Springer Science & Business Media. This book was released on 2006 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic oxidative stress is associated with the aging process and often leads to the development of disorders such as cancer and arterial disease. Cardiovascular conditions in which oxidation damage has been strongly implicated include atherosclerosis, myocardial ischemia and reperfusion, coronary restenosis, diabetes mellitus, and congestive heart failure. Antioxidants and Cardiovascular Disease, Second Edition covers three major topics: 1) the first seven chapters review the oxidative modifcation hypothesis and its close relationship to lipid metabolism and to the pathogenesis of atherosclerosis; 2) the next four chapters describe the different compounds, nutrients and supplements with antioxidant properties and their mechanisms of action; 3) and finallly, the last ten chapters discuss the potential benefits of antioxidants in overall cardiovascular prevention, including hypertension, diabetes mellitus, dyslipidemias, and in the treatment and prevention of specific conditions such as chronic coronary artery disease, restenosis after percutaneous coronary intervention, and chronic heart failure. Antioxidants and Cardiovascular Disease, Second Edition is written by recognized experts in the fields of atherosclerosis, heart failure and antioxidants. It should be of interest to medical students and fellows, researchers, and practicing physicians. There has been rapid progress in our knowledge in this field during the last two to three years. Thus the current reedition appears timely. For instance, this second edition captures several recently reported and published clinical trials as welll as new information on diabetic and hypertensive cardiovascular disease.

Author : Guillem Pons-Llado
Publisher : Springer Science & Business Media
ISBN 13 : 0387236341
Total Pages : 158 pages
Book Rating : 4.46/5 ( download)

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Download or read book Atlas of Practical Applications of Cardiovascular Magnetic Resonance written by Guillem Pons-Llado and published by Springer Science & Business Media. This book was released on 2005-12-28 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: • Richly illustrated with over 200 illustrations • Contains a Glossary of Terms • Very practical and user-friendly guide

Author : José Marín-García
Publisher : Springer Science & Business Media
ISBN 13 : 0387255753
Total Pages : 416 pages
Book Rating : 4.50/5 ( download)

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Download or read book Mitochondria and the Heart written by José Marín-García and published by Springer Science & Business Media. This book was released on 2005-12-17 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria have been pivotal in the development of some of the most important ideas in modern biology. Since the discovery that the organelle has its own DNA and specific mutations were found in association with neuromuscular and cardiovascular diseases and with aging, an extraordi-nary number of publications have followed, and the term mitochondrial medicine was coined. Furthermore, our understanding of the multiple roles that mitochondria play in cardiac cell homeostasis opened the door for intensive experimentation to understand the pathogenesis and to find new treatments for cardiovascular diseases. Besides its role in adenosine triphosphate generation, mitochondria regu-late a complex network of cellular interactions, involving (1) generation and detoxification of reactive oxygen species, including superoxide anion, hy-drogen peroxide, and hydroxyl radical; (2) maintenance of the antioxidant glutathione in a reduced state and adequate level of mitochondrial matrix superoxide dismutase; (3) cytoplasmic calcium homeostasis, particularly under conditions of cellular calcium loading; (4) transport of metabolites between cytoplasm and matrix; (5) both programmed (apoptosis) and necrotic cell death; and (6) cell growth and development. It is therefore not surprising that this organelle has come to be the center stage in many current investigations of cardiovascular diseases, aging, and agi- related disease. Concomitant with these advances, an impressive effort is under- way for the development of new tools and methodologies to study mitochondrial structure and function, including powerful ways to visualize, monitor, and alter the organelle function to assess the genetic consequences of these perturbations.

Author : Macdonald Dick
Publisher : Springer Science & Business Media
ISBN 13 : 0387291709
Total Pages : 331 pages
Book Rating : 4.03/5 ( download)

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Download or read book Clinical Cardiac Electrophysiology in the Young written by Macdonald Dick and published by Springer Science & Business Media. This book was released on 2006-08-13 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the practical aspects of clinical electrophysiology of cardiac arrhythmias in the young as practiced in the Department of Pediatric Cardiology at the University of Michigan. Cardiac arrhythmias in children are often symptomatic as well as frightening to the child patient and parent. This volume is intended as a practical guide for the novice or seasoned physician presented with a child with a cardiac arrhythmia.

Author : Akira Matsumori
Publisher : Springer Science & Business Media
ISBN 13 : 1441992642
Total Pages : 572 pages
Book Rating : 4.42/5 ( download)

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Download or read book Cardiomyopathies and Heart Failure written by Akira Matsumori and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprises the most up-to-date account of existing knowledge on the subject of cardiomyopathy and heart failure. Its multidisciplinary approach covers cardiovascular medicine; biochemistry; immunology; molecular biology; virology; epidemiology; and clinical medicine. Cardiomyopathies and Heart Failure: -Covers all major investigational and clinical aspects of the topic; -Provides syntheses as well as reviews; -Offers a unique multidisciplinary and international perspective; -Includes an extensive list of references to relevant work; -Targeted towards practicing physicians and basic researchers.

Author : Francisco Villarreal
Publisher : Springer Science & Business Media
ISBN 13 : 038722825X
Total Pages : 370 pages
Book Rating : 4.59/5 ( download)

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Download or read book Interstitial Fibrosis in Heart Failure written by Francisco Villarreal and published by Springer Science & Business Media. This book was released on 2005-12-17 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis. This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment.

Author : Jack Rychik
Publisher : Springer Science & Business Media
ISBN 13 : 1461502535
Total Pages : 430 pages
Book Rating : 4.31/5 ( download)

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Download or read book Hypoplastic Left Heart Syndrome written by Jack Rychik and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite approximately 50 years of progress in the management of com plex congenital heart disease, hypoplastic left heart syndrome (HLHS) has been one of the last cardiac malformations to yield to effective surgical treat ment. The surgical therapies for hypoplastic left heart syndrome have evolved by two quite disparate routes. One approach has been the staged reconstruc tion operations utilizing an initial operation pioneered by many but developed by Dr. William Norwood and subsequently modified by many other investigators. The first stage reconstruction operation has been refined and standardized such that the majority of infants now proceed to second and third stage reconstruc tive operations culminating in a Pontan Kreutzer single ventricle physiology. An alternative surgical approach has been the development of neonatal and infant heart transplantation for HLHS. This approach also has had a signifi cant impact on the treatment of HLHS and other cardiac malformations and has been associated with good intermediate term results. Both of the thera peutic approaches devised for treatment of hypoplastic left heart syndrome have been effective and the outcomes are continuing to improve with each.