Cancer Chemoprevention

Author : John M. Pezzuto
Publisher : Springer Nature
ISBN 13 : 3030398552
Total Pages : 639 pages
Book Rating : 4.52/5 ( download)

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Download or read book Natural Products for Cancer Chemoprevention written by John M. Pezzuto and published by Springer Nature. This book was released on 2020-04-03 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research.

Author : Manish Kumar
Publisher : Springer Nature
ISBN 13 : 9811559996
Total Pages : 344 pages
Book Rating : 4.90/5 ( download)

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Download or read book Pharmacotherapeutic Botanicals for Cancer Chemoprevention written by Manish Kumar and published by Springer Nature. This book was released on 2020-07-20 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Author : Gary J. Kelloff
Publisher : Springer Science & Business Media
ISBN 13 : 1592597688
Total Pages : 543 pages
Book Rating : 4.80/5 ( download)

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Download or read book Cancer Chemoprevention written by Gary J. Kelloff and published by Springer Science & Business Media. This book was released on 2008-08-17 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite significant advances in cancer treatment and measures of neoplastic progression, drug effect (or early detection, overall cancer incidence has increased, pharmacodynamic markers), and markers that measure cancer-associated morbidity is considerable, and overall prognosis as well as predict responses to specific therapy. cancer survival has remained relatively flat over the past All these biomarkers have the potential to greatly augment several decades (1,2). However, new technology the development of successful chemoprevention therapies, allowing exploration of signal transduction pathways, but two specific types of biomarkers will have the most identification of cancer-associated genes, and imaging of immediate impact on successful chemopreventive drug tissue architecture and molecular and cellular function is development—those that measure the risk of developing increasing our understanding of carcinogenesis and cancer invasive life-threatening disease, and those whose mo- progression. This knowledge is moving the focus of cancer lation can “reasonably predict” clinical benefit and, therapeutics, including cancer preventive treatments, to therefore, serve as surrogate endpoints for later-occurring drugs that take advantage of cellular control mechanisms clinical disease. Thus far, the biomarker that best measures to selectively suppress cancer progression. these two phenomena is intraepithelial neoplasia (IEN) Carcinogenesis is now visualized as a multifocal, because it is a near obligate precursor to cancer.

Author : H.-J. Senn
Publisher : Springer Science & Business Media
ISBN 13 : 3642599451
Total Pages : 205 pages
Book Rating : 4.53/5 ( download)

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Download or read book Chemoprevention of Cancer written by H.-J. Senn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacologic interventions to prevent the evolution of human cancers are still in its infancy, although a good number o- mostly controlled - clinical studies have been performed in the past two decades. However, regarding the partially stagnating therapeutic results of major epithelial cancer types such as breast-, lung-, colon- and ENT-cancer types, the problem of in terference with the evolution of disease at a preclinical level is an intriguing one, and the field seems to develop into one of the fastest growing domaines of modern oncology. This process is fa cilitated by the developments of molecular on co-genetics and the gowing existence of family cancer units, allowing to better identi fy and inform respective high risk groups, thus enabling re searchers and clinicians to more realistically target their chemo preventive efforts to the true populations at risk. On this changing background, the newly formed International Society of Cancer Chemoprevention (ISCaC) together with the Swiss Cancer League and the Interdisciplinary Oncology Center of St. Gallen/Switzerland organized an international Symposium in September 1997, inviting basic researchers, epidemiologists and clinical oncologists of related disciplines to discuss pertinent issues of experimental and clinical chemo- and bio-prevention in a scientific workshop.

Author : Gary J. Kelloff
Publisher : Springer Science & Business Media
ISBN 13 : 159259767X
Total Pages : 998 pages
Book Rating : 4.73/5 ( download)

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Download or read book Cancer Chemoprevention written by Gary J. Kelloff and published by Springer Science & Business Media. This book was released on 2004-06-04 with total page 998 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM in pocket at end of v. 2 contains a compact e-book version of v. 2.

Author : Raymond C. Bergan
Publisher : Springer
ISBN 13 :
Total Pages : 336 pages
Book Rating : 4.55/5 ( download)

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Download or read book Cancer Chemoprevention written by Raymond C. Bergan and published by Springer. This book was released on 2001 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Great advances were made in the pharmacologic-based treatment of cancer in prior decades. However, despite a marked increase in our understanding ofcell and molecular mechanisms underlying the neoplastic process, therapy for advanced disease remains limited. While the reasons for this are many, it is generally accepted that advanced neoplasms contain a relatively large number of genetic and molecularalterations contributingto the maintenanceofthe neoplastic process. Such a situation precludes easy pharmacologic intervention. However, our ability to detect cancer at an earlier stage, coupled with our increased understandingofcarcinogenesis, are propellingboth basic and clinical scientiststo pursue early intervention/chemopreventive approaches. This is based upon the notion that fewer molecularaberrations are presentearlyon inthedisease process. It also takes advantage ofthe fact that advances in both technology, and in the field ofcancer biology, coupled with a heightened vigilance, have increased our ability to detect early disease more readily. The chemopreventive approach is highly attractive for a number ofreasons. First, treatment ofpre-neoplastic, or early neoplastic, lesions would prevent the significant mobility and mortality associated with advanced neoplastic disorders.

Author : Mohammad Fahad Ullah
Publisher : Springer
ISBN 13 : 3319214616
Total Pages : 376 pages
Book Rating : 4.10/5 ( download)

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Download or read book Critical Dietary Factors in Cancer Chemoprevention written by Mohammad Fahad Ullah and published by Springer. This book was released on 2015-10-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the prophylactic potential of diet-derived factors in primary prevention of cancer. It is written by a group of highly reputed experts in the area of dietary agents and cancer chemoprevention. The translational potential of dietary factors from epidemiological, laboratory and clinical studies as prevention strategy in normal and risk populations is highlighted. The work presents options of routine inclusion of specific dietary regimens for prevention as well as therapeutic strategy for better management through adjuvant interventions in cancer treatment.

Author : Daniel W. Nixon
Publisher : CRC Press
ISBN 13 : 9780849368509
Total Pages : 160 pages
Book Rating : 4.02/5 ( download)

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Download or read book Chemoprevention of Cancer written by Daniel W. Nixon and published by CRC Press. This book was released on 1994-11-08 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.

Author : Lee Wattenberg
Publisher : CRC Press
ISBN 13 : 9780849347153
Total Pages : 654 pages
Book Rating : 4.57/5 ( download)

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Download or read book Cancer Chemoprevention written by Lee Wattenberg and published by CRC Press. This book was released on 1992-08-20 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ultimate goal of cancer chemoprevention research and development is the identification of pharmaceutical or dietary constituents that will prevent cancer. Cancer Chemoprevention presents the proceedings of a large workshop on cancer chemoprevention that highlights the latest knowledge in the field, in addition to issues and ideas concerning future directions. Retinoids, sulfur compounds, and a large number of many naturally occurring cancer inhibitors in the diet are discussed, including green tea, garlic constituents, citrus fruit oils, and beans and seeds containing protease inhibitors. Compounds that may prevent the formation of carcinogens in food are covered, and the mechanisms by which chemical or dietary agencts produce cancer inhibitors are discussed.

Author : Summya Rashid
Publisher : Springer
ISBN 13 : 9811025797
Total Pages : 173 pages
Book Rating : 4.92/5 ( download)

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Download or read book Cancer and Chemoprevention: An Overview written by Summya Rashid and published by Springer. This book was released on 2017-07-05 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the most recent, relevant, comprehensive and significant advances in cancer and chemo prevention. It broadly discusses cancer, its hallmarks and classification, molecular mechanisms of outbreak, contributing factors, role of oxidative stress, inflammatory mediators and evading apoptosis, which leads to the progression of disease. Though modern medicine has left us with no option to treat this deadly disease due to drawbacks associated with conventional treatment – like its non-targeted nature, drug resistance, varied organ toxicities and unaffordability – chemoprevention offers a viable therapeutic window. Given chemoprevention’s importance in the present scenario, the book highlights various chemo preventive strategies currently used in the management of cancer; a selection of novel chemo preventive agents used at clinics and in the pre-clinical stage; hurdles to effective chemoprevention; future prospects and the road ahead. It offers a valuable guide for all graduate students and researchers seeking information on cancer and chemoprevention in general, irrespective of the specific type/pathways involved in its onset.