Calcium And Ion Channel Modulation

Author : A. D. Grinnell
Publisher : Springer Science & Business Media
ISBN 13 : 1461309751
Total Pages : 442 pages
Book Rating : 4.58/5 ( download)

DOWNLOAD NOW!

Download or read book Calcium and Ion Channel Modulation written by A. D. Grinnell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular neurobiology has been transformed in the past decade by new technologies and fundamental discoveries. One result is an enormous increase in our understanding of how ion channels function in nerve and muscle cells and a widening perspective on the role of ion channels in non-neuronal cell physiology and development. Patch clamp techniques now permit direct observation of the transitions between functional confor mations of individual ion channels in their native membrane. Recombinant DNA techniques are being used to determine the primary structure of ion channel proteins and to test hypotheses about channel conformations, sites of grating and modulation, and the basis of ion selectivity. At the same time, biochemical techniques have revealed intricate signalling systems in side cells, involving second messengers such as calcium, phospholipids and cyclic nucleotides, which interface with the external milieu through GTP binding proteins and regulate cell metabolism by altering protein phos phorylation. This panorama of second messenger systems has greatly increas ed our application for their potential role in regulating ion channel function. We now recognize that ion channels are much more complicated than we once thought, and more interesting. They are not simply isolated macro molecules in the membrane, gated directly by depolarization or trans mitter binding to open briefly at a fixed conductance and then close or inactivate. Instead, individual channels now appear to have many open and closed states that are regulated independently by voltage and transmitters.

Author : A. D Grinnell
Publisher :
ISBN 13 : 9781461309765
Total Pages : 464 pages
Book Rating : 4.6X/5 ( download)

DOWNLOAD NOW!

Download or read book Calcium and Ion Channel Modulation written by A. D Grinnell and published by . This book was released on 1988-06-01 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Valentin K. Gribkoff
Publisher : John Wiley & Sons
ISBN 13 : 0470429895
Total Pages : 505 pages
Book Rating : 4.91/5 ( download)

DOWNLOAD NOW!

Download or read book Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels written by Valentin K. Gribkoff and published by John Wiley & Sons. This book was released on 2008-12-09 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.

Author : L. Donald Partridge
Publisher : CRC Press
ISBN 13 : 9780849388071
Total Pages : 510 pages
Book Rating : 4.74/5 ( download)

DOWNLOAD NOW!

Download or read book Calcium Channels written by L. Donald Partridge and published by CRC Press. This book was released on 1991-07-03 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive compendium of information available on calcium channels Calcium channels are a common component of the membranes of a wide range of excitable cells, and their presence is crucial to the functioning of these cells. This book presents a current review of the biophysics, physiology, pharmacology, and clinical role of calcium channels. Chapters discussing the biophysics of calcium channels include topics in ion permeation, channel activation, channel inactivation, and second messenger modulation. The chapters on physiology cover excitation-contraction coupling, excitation-secretion coupling, sensory transduction, regulation of electrical activity, and the regulation of cell growth and development. Issues discussed in the pharmacology chapters of the book include the effects of permeant and inhibitory inorganic ions, blocking and activating effects of organic ions, and the regulatory effects of naturally occurring compounds. The chapters exploring the clinical aspects of calcium channels examine topics such as the modulation of calcium channels in the treatment of ischemic heart disease, cardiomyopathies, hypertension, cardiac arrhythmias, peripheral vascular diseases, platelet-related disorders, neurological disorders, and psychiatric disorders. Physicians neuroscientists, and pharmacologists should consider this book essential to their reference collections.

Author : Fatima Shad Kaneez
Publisher : BoD – Books on Demand
ISBN 13 : 1789842271
Total Pages : 204 pages
Book Rating : 4.72/5 ( download)

DOWNLOAD NOW!

Download or read book Ion Channels in Health and Sickness written by Fatima Shad Kaneez and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.

Author : Juliusz Ashot Kozak
Publisher : CRC Press
ISBN 13 : 149875273X
Total Pages : 343 pages
Book Rating : 4.32/5 ( download)

DOWNLOAD NOW!

Download or read book Calcium Entry Channels in Non-Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.

Author : Alan Dale Grinnell
Publisher :
ISBN 13 :
Total Pages : 435 pages
Book Rating : 4.47/5 ( download)

DOWNLOAD NOW!

Download or read book Calcium and Ionchannel Modulation written by Alan Dale Grinnell and published by . This book was released on 1988 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Gerald Werner Zamponi
Publisher : Springer Science & Business Media
ISBN 13 : 0387275266
Total Pages : 392 pages
Book Rating : 4.60/5 ( download)

DOWNLOAD NOW!

Download or read book Voltage-Gated Calcium Channels written by Gerald Werner Zamponi and published by Springer Science & Business Media. This book was released on 2007-02-26 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar macological targets in the treatment of a variety of disorders, such as epi lepsy, hypertension, and pain. Voltage-gated calcium channels have there fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac tivity, the book delves into a provocative overview of the history of the cal cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat ing, permeation, modulation and interactions with members of the exo- totic machinery—contributed by both established leaders and rising stars in the field.

Author : William J. Brammar
Publisher : Academic Press
ISBN 13 : 0080535208
Total Pages : 905 pages
Book Rating : 4.03/5 ( download)

DOWNLOAD NOW!

Download or read book Ion Channel Factsbook written by William J. Brammar and published by Academic Press. This book was released on 1998-10-16 with total page 905 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Academic Press FactsBooks series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as 'a growing series of excellent manuals' by Molecular Medicine Today, and 'essential works of reference' by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. As they are meticulously researched and use an easy-to-follow format, the FactsBooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity.In a set of four interrelated volumes, The Ion Channel FactsBook provides a comprehensive framework of facts about channel molecules central to electrical signaling phenomena in living cells. The fourth volume is devoted to Voltage-gated Channel Families, including those molecular complexes activated or modulated by calcium, potassium, and chloride. Nomenclature Expression Sequence Analyses Structure and function Electrophysiology Pharmacology Information retrieval

Author : Jörg Striessnig
Publisher : Springer Nature
ISBN 13 : 3031384377
Total Pages : 319 pages
Book Rating : 4.70/5 ( download)

DOWNLOAD NOW!

Download or read book Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease written by Jörg Striessnig and published by Springer Nature. This book was released on 2023-07-31 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.