Brain Energetics And Neuronal Activity

Author : Robert G. Shulman
Publisher : John Wiley & Sons
ISBN 13 : 0470020512
Total Pages : 336 pages
Book Rating : 4.17/5 ( download)

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Download or read book Brain Energetics and Neuronal Activity written by Robert G. Shulman and published by John Wiley & Sons. This book was released on 2005-08-19 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states It provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders. Novel and potentially controversial Will inspire future research directions

Author : Yuri Zilberter
Publisher : Frontiers E-books
ISBN 13 : 2889191273
Total Pages : 120 pages
Book Rating : 4.77/5 ( download)

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Download or read book The link between brain energy homeostasis and neuronal activity written by Yuri Zilberter and published by Frontiers E-books. This book was released on with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is an extremely energy consuming part of the body, which makes it dangerously vulnerable to metabolic stress. It’s no wonder then that abnormalities of brain energy metabolism are becoming the usual suspects and a hallmark of many neurodegenerative diseases. The socioeconomic burden of these alone begs for urgent measures to be taken for better understanding both fundamental and applied problems of neuroenergetics and neuroprotection. For instance, brain imaging reveals that the diseased brains of Alzheimer’s patients cannot efficiently utilize the vital brain fuel, glucose. The resulting energy deficit causes neuronal hyperactivity, seizures and cognitive impairments. Administration of native energy substrates complementary to glucose is a logical (and attractive in its simplicity) approach in fighting the energy crisis in the brain*. The two closely related aspects of brain activity -- neuronal and metabolic – are currently considered to be of utmost importance in both fundamental and applied neuroscience. Although recently the studies of both brain activity and metabolism in normal conditions, under metabolic stress, and in neurodegenerative diseases have experienced significant progress, their overlapping areas deserve further clarification by joint efforts from experts in such fields as (1) energy demands, supplies, and efficiency at the cellular level: in neurons, glial elements, micro-vessels and in the process of their coordinated interactions; (2) specific roles of energy substrates in fine-tuning of the demand-supply mechanism in the condition of metabolic stress; and (3) the macro-level of energy homeostasis and dietary manipulations possible beneficial for neurodegenerative diseases. The result of combining into a coherent whole the recent findings in these fields will hopefully bring forward a broader view and better understanding of the knowledge continuum, which is under the threat of further fragmentation due to the unavoidable process of specialization in neuroscience. Current issue covers the three major groups of topics: 1. The Pros and Cons of studies of neuronal activity using brain slice preparations 2. The role of particular energy substrates in metabolic support of neuronal activity 3. The macro-level of energy homeostasis and the dietary manipulations that seem promising in prevention and correction of the diseases of brain energy metabolism.

Author : Johannes Hirrlinger
Publisher : Humana Press
ISBN 13 : 9781493910588
Total Pages : 0 pages
Book Rating : 4.82/5 ( download)

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Download or read book Brain Energy Metabolism written by Johannes Hirrlinger and published by Humana Press. This book was released on 2014-09-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab. Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.

Author : Gary E. Gibson
Publisher : Springer Science & Business Media
ISBN 13 : 0387303669
Total Pages : 917 pages
Book Rating : 4.66/5 ( download)

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Download or read book Handbook of Neurochemistry and Molecular Neurobiology written by Gary E. Gibson and published by Springer Science & Business Media. This book was released on 2007-03-13 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Anusha Priya
Publisher :
ISBN 13 : 9781321196092
Total Pages : 228 pages
Book Rating : 4.91/5 ( download)

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Download or read book Mechanisms of Coupling Energy Metabolism and Neuronal Activity at the Molecular Level written by Anusha Priya and published by . This book was released on 2013 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : In-Young Choi
Publisher : Springer Science & Business Media
ISBN 13 : 1461417872
Total Pages : 1168 pages
Book Rating : 4.73/5 ( download)

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Download or read book Neural Metabolism In Vivo written by In-Young Choi and published by Springer Science & Business Media. This book was released on 2012-03-14 with total page 1168 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the preface: “Neural Metabolism In Vivo aims to provide a comprehensive overview of neurobiology by presenting the basic principles of up-to-date and cutting-edge technology, as well as their application in assessing the functional, morphological and metabolic aspects of the brain. Investigation of neural activity of the living brain via neurovascular coupling using multimodal imaging techniques extended our understanding of fundamental neurophysiological mechanisms, regulation of cerebral blood flow in connection to neural activity and the interplay between neurons, astrocytes and blood vessels. Constant delivery of glucose and oxygen for energy metabolism is vital for brain function, and the physiological basis of neural activity can be assessed through measurements of cerebral blood flow and consumption of glucose and oxygen.... This book presents the complex physiological and neurochemical processes of neural metabolism and function in response to various physiological conditions and pharmacological stimulations. Neurochemical detection technologies and quantitative aspects of monitoring cerebral energy substrates and other metabolites in the living brain are described under the “Cerebral metabolism of antioxidants, osmolytes and others in vivo” section. Altogether, the advent of new in vivo tools has transformed neuroscience and neurobiology research, and demands interdisciplinary approaches as each technology could only approximate a very small fraction of the true complexity of the underlying biological processes. However, translational values of the emerging in vivo methods to the application of preclinical to clinical studies cannot be emphasized enough. Thus, it is our hope that advances in our understanding of biochemical, molecular, functional and physiological processes of the brain could eventually help people with neurological problems, which are still dominated by the unknowns.” -- In-Young Choi and Rolf Gruetter

Author : Abel Lajtha
Publisher : Springer
ISBN 13 : 9780306409721
Total Pages : 516 pages
Book Rating : 4.20/5 ( download)

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Download or read book Experimental Neurochemistry written by Abel Lajtha and published by Springer. This book was released on 1982-12-01 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume of the Handbook does not parallel any volume of the first edition; it is one more sign, or reflection, of the expansion of the field. By emphasizing the experimental approach, it illustrates the tools that have re cently become available for investigating the nervous system. Also, perhaps even more than other volumes, it illustrates the multidisciplinary nature of the field, requiring multidisciplinary methodology. It is now recognized that the availability of methodology is often the rate-limiting determinant of studies and that improvements or innovations in instrumentation can open up new avenues. A new improved method, although opening up new possibilities and being crucial to making advances, is only a tool whose use will determine its use fulness. If we do not recognize its possibilities, its use will be limited; if we do not recognize its limitations, it will mislead us. It is the possibilities and limitations and the results obtained that are illustrated here.

Author : Francisco Gonzalez-Lima
Publisher : Springer Science & Business Media
ISBN 13 : 1475799365
Total Pages : 294 pages
Book Rating : 4.61/5 ( download)

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Download or read book Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s Disease written by Francisco Gonzalez-Lima and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on an international symposium titled "Cytochrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T. T. Wong-Riley because, in our opinion, the cytochrome oxidase histo chemical method introduced by Dr. Wong-Riley in 1979 was the most significant break through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic map ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized tech niques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cytochrome oxidase cytochemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cytochrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually re sulting in failure of oxidative energy metabolism. Could impairment of cytochrome oxi dase in energy metabolism initiate the degenerative process? Cytochrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegen eration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts.

Author : Bo K. Siesjö
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 634 pages
Book Rating : 4.64/5 ( download)

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Download or read book Brain Energy Metabolism written by Bo K. Siesjö and published by John Wiley & Sons. This book was released on 1978 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Derek Richter
Publisher : Elsevier
ISBN 13 : 1483184358
Total Pages : 664 pages
Book Rating : 4.57/5 ( download)

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Download or read book Metabolism of the Nervous System written by Derek Richter and published by Elsevier. This book was released on 2013-10-22 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism of the Nervous System contains the proceedings of the 2nd International Neurochemical Symposium, held at Aarhus, Denmark, in July 1956. The book discusses the molecular structure and morphology of the adult nervous tissue; the chemical composition and cytochemical localization of adult nervous tissue; and the permeability and blood-brain barrier. The text also describes topics on electrolytes and nervous conduction; the metabolism of isolated nerve and ganglion; and the metabolism of the brain in vivo. The metabolism of brain tissue preparations in vitro; energy metabolism and coenzymes in relation to the nervous system; and lipid and fatty acid metabolism are also considered. The book further tackles nucleic acid metabolism; protein and amino acid metabolism; and cholinergic and non-cholinergic transmission. The text also discusses other pharmacologically active compounds related to the adult nervous tissue.