Bioreactor Design Concepts For Viral Vaccine Production

Author : Surajbhan Sevda
Publisher : Elsevier
ISBN 13 : 0443153795
Total Pages : 476 pages
Book Rating : 4.92/5 ( download)

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Download or read book Bioreactor Design Concepts for Viral Vaccine Production written by Surajbhan Sevda and published by Elsevier. This book was released on 2024-05-12 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioreactor Design Concepts for Viral Vaccine Production covers a range of interdisciplinary chapters from the engineering perspective of bioreactor design to the biotechnological perspectives of vector design for vaccine development. The book covers bioreactor concepts such as static systems, single-use systems, stirred tanks, perfusion, wave and packed-beds. It reviews options for efficient and economical production of human vaccines and discusses basic factors relevant for viral antigen production in mammalian cells, avian cells, and insect cells. This book will be a great resource for those interested in implemented novel bioreactor design or experimental schemes towards intensified or/and enhanced vaccine production. Covers the fundamentals of bioreactor designs Provides strategies for designing a successful vector-based vaccine Discusses the applications of biological kinetics, thermodynamics and basic substrate requirements for viral vaccine production

Author : Amine Kamen
Publisher : CRC Press
ISBN 13 : 1000643050
Total Pages : 267 pages
Book Rating : 4.53/5 ( download)

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Download or read book Bioprocessing of Viral Vaccines written by Amine Kamen and published by CRC Press. This book was released on 2022-09-06 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on cell culture-produced viral vaccines to meet the needs of the rapidly expanding research and development in academia and industry in the field. This book introduces the basic principles of vaccination and the manufacturing of viral vaccines. Bioprocessing of Viral Vaccines, will provide an overview of the advanced strategies needed to respond to the challenges of new and established viral infection diseases. The first few chapters cover the basics of virology and immunology as essential concepts to understand the function and design of viral vaccines. The core of the content is dedicated to process development, including upstream processing and cell culture of viral vaccines, downstream processing, and extensive analytical technologies specific to viral vaccines. Advanced process analytical technologies (PAT) and Quality by Design (QbD) concepts are also introduced in the context of vaccine manufacturing. The case studies included cover inactivated, attenuated vaccines exemplified by influenza vaccines, sub-unit vaccines exemplified by Virus Like Particles (VLPs: HPV vaccines) and sub-unit vaccines (Flublock), vectored vaccines: adenoviruses and Vesicular stomatitis Virus (VSV) vectored vaccines, genomic vaccines (DNA and mRNA) vaccines as developed for COVID-19 response in particular and a review of COVID-19 vaccines approved or in advanced clinical trials. This book is aimed at graduate engineers and professionals in the fields of vaccinology, bioprocessing, and biomanufacturing of viral vaccines.

Author : Kaylee Christine Schickel
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.04/5 ( download)

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Download or read book Design and Analysis of Methods to Eliminate Oscillatory Behavior in Bioreactors for Viral Vaccine Manufacturing written by Kaylee Christine Schickel and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thus, tracking cell ages provides avenues to design new systems that may be able to filter such aging cell populations out, thereby potentially increasing the overall productivity of the system. The groundwork for this is providing solution strategies for population balance models including numerical approaches as well as direct analytical solutions. Both approaches are analyzed here in great depth.

Author : Luigi Salvay
Publisher :
ISBN 13 : 9781681176956
Total Pages : 304 pages
Book Rating : 4.55/5 ( download)

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Download or read book Bioreactors written by Luigi Salvay and published by . This book was released on 2017-02 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Saurabh Gautam
Publisher : Springer Nature
ISBN 13 : 3031284895
Total Pages : 448 pages
Book Rating : 4.92/5 ( download)

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Download or read book Bioprocess and Analytics Development for Virus-based Advanced Therapeutics and Medicinal Products (ATMPs) written by Saurabh Gautam and published by Springer Nature. This book was released on 2023-08-10 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the knowledge, methods and available techniques in the rapidly advancing field of virus based vaccines and gene therapeutics. It also highlights new innovative tools and interdisciplinary techniques for bioprocess development and analytics of viruses and viral vectors. As such, it provides a timely and highly relevant resource, since current advances in pharmaceutical research have seen the rise of vaccines and advanced therapeutics and medicinal products (ATMPs), that rely on the power of viruses. However, developing bioprocesses and analytics required to create this often called “magic bullet” (i.e. gene therapy) remains an extremely challenging and costly task. This book offers strategies for overcoming hurdles and difficulties within in all the necessary steps of viral vector development - from scalability to purification methods and quality control. The book is intended for researchers working in academia or industry, as well as graduate students pursuing a career in virology.

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
ISBN 13 : 0128136308
Total Pages : 696 pages
Book Rating : 4.00/5 ( download)

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Download or read book Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2017-12-11 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Author : Binoy Ranjan Maiti
Publisher :
ISBN 13 : 9789387925076
Total Pages : 587 pages
Book Rating : 4.72/5 ( download)

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Download or read book Principles of Bioreactor Design written by Binoy Ranjan Maiti and published by . This book was released on 2018 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Regine Eibl
Publisher : John Wiley & Sons
ISBN 13 : 1119477786
Total Pages : 368 pages
Book Rating : 4.85/5 ( download)

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Download or read book Single-Use Technology in Biopharmaceutical Manufacture written by Regine Eibl and published by John Wiley & Sons. This book was released on 2019-07-18 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authoritative guide to the principles, characteristics, engineering aspects, economics, and applications of disposables in the manufacture of biopharmaceuticals The revised and updated second edition of Single-Use Technology in Biopharmaceutical Manufacture offers a comprehensive examination of the most-commonly used disposables in the manufacture of biopharmaceuticals. The authors—noted experts on the topic—provide the essential information on the principles, characteristics, engineering aspects, economics, and applications. This authoritative guide contains the basic knowledge and information about disposable equipment. The author also discusses biopharmaceuticals’ applications through the lens of case studies that clearly illustrate the role of manufacturing, quality assurance, and environmental influences. This updated second edition revises existing information with recent developments that have taken place since the first edition was published. The book also presents the latest advances in the field of single-use technology and explores topics including applying single-use devices for microorganisms, human mesenchymal stem cells, and T-cells. This important book: • Contains an updated and end-to-end view of the development and manufacturing of single-use biologics • Helps in the identification of appropriate disposables and relevant vendors • Offers illustrative case studies that examine manufacturing, quality assurance, and environmental influences • Includes updated coverage on cross-functional/transversal dependencies, significant improvements made by suppliers, and the successful application of the single-use technologies Written for biopharmaceutical manufacturers, process developers, and biological and chemical engineers, Single-Use Technology in Biopharmaceutical Manufacture, 2nd Edition provides the information needed for professionals to come to an easier decision for or against disposable alternatives and to choose the appropriate system.

Author : Wei-Shou Hu
Publisher : CRC Press
ISBN 13 : 0429531893
Total Pages : 576 pages
Book Rating : 4.97/5 ( download)

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Download or read book Cell Culture Bioprocess Engineering, Second Edition written by Wei-Shou Hu and published by CRC Press. This book was released on 2020-03-06 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the culmination of three decades of accumulated experience in teaching biotechnology professionals. It distills the fundamental principles and essential knowledge of cell culture processes from across many different disciplines and presents them in a series of easy-to-follow, comprehensive chapters. Practicality, including technological advances and best practices, is emphasized. This second edition consists of major updates to all relevant topics contained within this work. The previous edition has been successfully used in training courses on cell culture bioprocessing over the past seven years. The format of the book is well-suited to fast-paced learning, such as is found in the intensive short course, since the key take-home messages are prominently highlighted in panels. The book is also well-suited to act as a reference guide for experienced industrial practitioners of mammalian cell cultivation for the production of biologics.

Author : Mohamed Al-Rubeai
Publisher : Springer
ISBN 13 : 3319103202
Total Pages : 766 pages
Book Rating : 4.04/5 ( download)

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Download or read book Animal Cell Culture written by Mohamed Al-Rubeai and published by Springer. This book was released on 2014-11-28 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​Animal cells are the preferred “cell factories” for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation) of biopharmaceutical protein products. They are used for the production of viral vectors for gene therapy. Major targets for this therapy include cancer, HIV, arthritis, cardiovascular and CNS diseases and cystic fibrosis. Animal cells are used as in vitro substrates in pharmacological and toxicological studies. This book is designed to serve as a comprehensive review of animal cell culture, covering the current status of both research and applications. For the student or R&D scientist or new researcher the protocols are central to the performance of cell culture work, yet a broad understanding is essential for translation of laboratory findings into the industrial production. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field to produce state-of-the-art collection of current research. A major reference volume on cell culture research and how it impacts on production of biopharmaceutical proteins worldwide, the book is essential reading for everyone working in cell culture and is a recommended volume for all biotechnology libraries.