Biophysical Approaches To Translational Control Of Gene Expression

Author : Jonathan D. Dinman
Publisher : Springer Science & Business Media
ISBN 13 : 1461439906
Total Pages : 325 pages
Book Rating : 4.05/5 ( download)

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Download or read book Biophysical Approaches to Translational Control of Gene Expression written by Jonathan D. Dinman and published by Springer Science & Business Media. This book was released on 2012-07-27 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights major advances in researching a cell’s molecular machinery through analytical, computational, and imaging methods. It focuses on developing biophysical approaches to studying control of gene expression at the translational level.

Author :
Publisher : Academic Press
ISBN 13 : 9780080911960
Total Pages : 300 pages
Book Rating : 4.6X/5 ( download)

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Download or read book Translational Control in Health and Disease written by and published by Academic Press. This book was released on 2009-10-26 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology and translational science. It contains contributions from leaders in their fields and abundant references. This volume focuses on translational control in health and disease. * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Author : Michael B. Mathews
Publisher :
ISBN 13 :
Total Pages : 212 pages
Book Rating : 4.03/5 ( download)

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Download or read book Translational Control written by Michael B. Mathews and published by . This book was released on 1986 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Nahum Sonenberg
Publisher :
ISBN 13 :
Total Pages : 1040 pages
Book Rating : 4.74/5 ( download)

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Download or read book Translational Control of Gene Expression written by Nahum Sonenberg and published by . This book was released on 2000 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is fresh interest in protein synthesis and recognition of the key role of translational control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the 1996 publication, Translational Control, but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translational machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.

Author : Chirlmin Joo
Publisher : Springer Nature
ISBN 13 : 1493997262
Total Pages : 249 pages
Book Rating : 4.68/5 ( download)

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Download or read book Biophysics of RNA-Protein Interactions written by Chirlmin Joo and published by Springer Nature. This book was released on 2019-09-19 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA molecules play key roles in all aspects of cellular life, but to do so efficiently, they must work in synergism with proteins. This book addresses how proteins and RNA interact to carry out biological functions such as protein synthesis, regulation of gene expression, genome defense, liquid phase separation and more. The topics addressed in this volume will appeal to researchers in biophysics, biochemistry and structural biology. The book is a useful resource for anybody interested in elucidating the molecular mechanisms and discrete properties of RNA-protein complexes. Included are reviews of key systems such as microRNA and CRISPR/Cas that exemplify how RNA and proteins work together to perform their biological function. Also covered are techniques ranging from single molecule fluorescence and force spectroscopy to crystallography, cryo-EM microscopy, and kinetic modeling.

Author : Koreaki Ito
Publisher : Springer
ISBN 13 : 4431550526
Total Pages : 313 pages
Book Rating : 4.25/5 ( download)

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Download or read book Regulatory Nascent Polypeptides written by Koreaki Ito and published by Springer. This book was released on 2014-08-19 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems. Translation lies in the hub of the central dogma of biology, in which the genetic information in the forms of 4-letter sentences is translated into 20-letter sentences: sequences of amino acids that constitute proteins, the functional molecules of life. The process involves a huge number of chemical reactions as well as physical movements of the ribosome along a messenger RNA and takes, on average, tens of seconds in prokaryotes and a few minutes in eukaryotes. Detailed knowledge about the progression of translation, called "elongation", only recently started to accumulate. Newly synthesized and growing polypeptides, called nascent polypeptides, can interact with the intra-ribosomal conduit, called the ribosomal exit tunnel, when they have some specific amino acid sequences, called "an arrest sequence". Such interaction leads to a halt in the elongation reaction. Resulting stalling of the ribosome on messenger RNA can affect the secondary structure and/or localization of the message in the cell, consequently leading to biological outputs such as elevation or reduction of a gene product. This book provides a first collection of knowledge focused on regulatory nascent polypeptides, which have been studied recently using diverse organisms including bacteria, plants, and animals. Readers will be impressed by a new paradigm showing that proteins can function even during the course of their biosynthesis and that the ribosome, the "factory" of protein production, interacts with and inspects its products to adjust the speed of completion of each product. Moreover, regulatory nascent polypeptides can sense or monitor physiological states of the cell and modulate its ability to arrest translation. Living organisms use such intricate control mechanisms of translational speed to regulate gene expression. This book will be a useful addition for established scientists while inspiring students and young scientists to gain deeper insights into the processes of expression of genetic information.

Author : Norma Allewell
Publisher : Springer Science & Business Media
ISBN 13 : 1461485487
Total Pages : 401 pages
Book Rating : 4.83/5 ( download)

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Download or read book Molecular Biophysics for the Life Sciences written by Norma Allewell and published by Springer Science & Business Media. This book was released on 2013-09-28 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of the development and scope of molecular biophysics and in-depth discussions of the major experimental methods that enable biological macromolecules to be studied at atomic resolution. It also reviews the physical chemical concepts that are needed to interpret the experimental results and to understand how the structure, dynamics, and physical properties of biological macromolecules enable them to perform their biological functions. Reviews of research on three disparate biomolecular machines—DNA helicases, ATP synthases, and myosin--illustrate how the combination of theory and experiment leads to new insights and new questions.

Author : Yujun George Zheng
Publisher : Academic Press
ISBN 13 : 0128013273
Total Pages : 516 pages
Book Rating : 4.74/5 ( download)

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Download or read book Epigenetic Technological Applications written by Yujun George Zheng and published by Academic Press. This book was released on 2015-05-30 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm. Discusses technologies that are critical for epigenetic research and application Includes epigenetic applications for state-of-the-art technologies Contains a global perspective on the future of epigenetics

Author :
Publisher : Elsevier
ISBN 13 : 0080553184
Total Pages : 510 pages
Book Rating : 4.84/5 ( download)

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Download or read book Translation Initiation: Reconstituted Systems and Biophysical Methods written by and published by Elsevier. This book was released on 2007-10-09 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the second of three on the topic of Translation Initiation includes articles written by leaders in the field.

Author : Laura Soucek
Publisher : Humana
ISBN 13 : 9781071614785
Total Pages : 349 pages
Book Rating : 4.89/5 ( download)

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Download or read book The Myc Gene written by Laura Soucek and published by Humana. This book was released on 2021-05-23 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides new and updated chapters detailing recent advances in MYC research and current techniques. Chapters guide readers through protocols on how to express and purify MYC protein, X-ray crystallography, NMR, techniques to study how MYC is modified, apoptosis, senescence, proliferation, metabolic changes, translation, tumorigenesis,reprogramming, and clinical application of MYC studies.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Myc Gene: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.