Biomarkers Of Neuroinflammation

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309463653
Total Pages : 89 pages
Book Rating : 4.52/5 ( download)

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Download or read book Biomarkers of Neuroinflammation written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-03-16 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

Author : Mohamed Mosaad Salama
Publisher : Frontiers Media SA
ISBN 13 : 2889636933
Total Pages : 173 pages
Book Rating : 4.38/5 ( download)

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Download or read book Biomarkers in Neurology written by Mohamed Mosaad Salama and published by Frontiers Media SA. This book was released on 2020-05-12 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Philip V. Peplow
Publisher :
ISBN 13 : 9781071617120
Total Pages : 565 pages
Book Rating : 4.25/5 ( download)

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Download or read book Neurodegenerative Diseases Biomarkers written by Philip V. Peplow and published by . This book was released on 2021 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.

Author : Alireza Minagar
Publisher : Elsevier
ISBN 13 : 9780123849144
Total Pages : 540 pages
Book Rating : 4.44/5 ( download)

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Download or read book Neuroinflammation written by Alireza Minagar and published by Elsevier. This book was released on 2010-12-17 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities

Author : Kevin K. W. Wang
Publisher : CRC Press
ISBN 13 : 1482239833
Total Pages : 647 pages
Book Rating : 4.36/5 ( download)

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Download or read book Biomarkers of Brain Injury and Neurological Disorders written by Kevin K. W. Wang and published by CRC Press. This book was released on 2014-10-28 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies

Author : Svetlana Dambinova
Publisher : Royal Society of Chemistry
ISBN 13 : 1849733899
Total Pages : 247 pages
Book Rating : 4.92/5 ( download)

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Download or read book Biomarkers for Traumatic Brain Injury written by Svetlana Dambinova and published by Royal Society of Chemistry. This book was released on 2012 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to injuries sustained in sports and in combat, interest in traumatic brain injury (TBI) has never been greater. This book will fulfill a gap in understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging.

Author : Paola Patrignani
Publisher : Frontiers Media SA
ISBN 13 : 2889742563
Total Pages : 192 pages
Book Rating : 4.61/5 ( download)

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Download or read book Resolution of Inflammation: Mechanisms, Mediators & Biomarkers written by Paola Patrignani and published by Frontiers Media SA. This book was released on 2022-02-01 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Waliza Ansar
Publisher : Springer
ISBN 13 : 8132226801
Total Pages : 301 pages
Book Rating : 4.02/5 ( download)

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Download or read book Biology of C Reactive Protein in Health and Disease written by Waliza Ansar and published by Springer. This book was released on 2016-03-23 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.

Author : Issam A. Awad
Publisher : Thieme
ISBN 13 : 9781879284074
Total Pages : 250 pages
Book Rating : 4.73/5 ( download)

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Download or read book Cavernous Malformations written by Issam A. Awad and published by Thieme. This book was released on 1993 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: The massive convergence of information about cavernous malformations has been synthesized in this volume by experts in the field of pathology, neuroradiology and neurosurgery. Cavernous Malformations represents state-of-the-art knowledge about this lesion and the spectrum of opinion about its nature, clinical behavior and management strategies. Highlights of Cavernous Malformations: Definition and pathologic features Epidemiology Diagnostic imaging Epilepsy Hemorrhage Conservative management Surgical intervention Microsurgical treatments Spinal cavernous malformations Pediatrics Radiotherapy (Distributed by Thieme for the American Association of Neurological Surgeons)

Author : Ulrich Dirnagl
Publisher : Springer Science & Business Media
ISBN 13 : 3662054264
Total Pages : 248 pages
Book Rating : 4.60/5 ( download)

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Download or read book Neuroinflammation in Stroke written by Ulrich Dirnagl and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.