Biochemical Modulation Of Skin Reactions

Author : Agis F. Kydonieus
Publisher : CRC Press
ISBN 13 : 9780849321177
Total Pages : 352 pages
Book Rating : 4.74/5 ( download)

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Download or read book Biochemical Modulation of Skin Reactions written by Agis F. Kydonieus and published by CRC Press. This book was released on 1999-12-15 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Like almost every major scientific or medical breakthrough in history, the transdermal delivery of drugs started as only an idea - slowly moving its way from the drawing board to actual testing and eventually approval. Today, there are more than 20 companies involved in transdermal drug delivery. In addition, almost every large pharmaceutical firm has ongoing transdermal delivery programs. But in spite of this effort and after 15 years from the introduction of the Nitroglycerin patch, only six transdermal drugs exist in the marketplace. The practice has been hampered by the fact that most drugs, as well as many excipients used in the manufacture of transdermal patches, cause skin irritation or skin sensitization. Similar problems exist with the application of dermatologicals and cosmetics to skin, which in many cases are equally as severe as those encountered in transdermal delivery. Biochemical Modulation of Skin Reactions: Transdermals, Topicals, Cosmetics presents a series of chapters describing technologies and the practical application of biochemicals which might lead to the reduction or abrogation of these skin reaction. In addition, it addresses those areas of skin immunology and skin sciences that account for the processes that control irritant and allergic contact dermatitis and outlines the numerous cellular and molecular factors involved in the development of irritation and sensitization. Indeed, Biochemical Modulation of Skin Reactions helps serve as a catalyst for further research in the field, allowing for more drugs and cosmetics to be applied to the skin without adverse effects. Features

Author : Camilla Smith
Publisher : CRC Press
ISBN 13 : 1420025058
Total Pages : 337 pages
Book Rating : 4.57/5 ( download)

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Download or read book Allergic Contact Dermatitis written by Camilla Smith and published by CRC Press. This book was released on 2023-01-06 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: llergic Contact Dermatitis assesses the potential effects of xenobiotic metabolism and protein reactivity on toxicity. It reviews current knowledge of percutaneous absorption and skin metabolism and includes discussion of the xenobiotics themselves. It answers questions such as: How does sensitisation relate to protein reactivity and levels of metabolism? How we can identify potential hazards in food, cosmetics and pharmaceuticals etc? In a world where people are becoming increasingly aware of their allergies, this up to date one-stop reference will prove an invaluable addition to the shelves of any researcher in academia, government, regulatory bodies, public health officials and, of course, the food, cosmetics and pharmaceuticals industries will find the book to be of particular relevance.

Author : J. Kielhorn
Publisher : World Health Organization
ISBN 13 : 9241572353
Total Pages : 217 pages
Book Rating : 4.54/5 ( download)

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Download or read book Dermal Absorption written by J. Kielhorn and published by World Health Organization. This book was released on 2006 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction and definitions -- Skin structure and function -- Skin transport mechanisms and theoretical concepts -- Metabolism in the skin -- In vitro tests for dermal absorption -- In vivo tests for dermal absorption -- Comparative studies -- Data collections -- Estimation/prediction of dermal penetration -- Use of dermal penetration studies in risk assessment -- Controversial topics in the assessment of dermal absorption -- Conclusions and recommendations.

Author : E. Carstens
Publisher : CRC Press
ISBN 13 : 1466505435
Total Pages : 482 pages
Book Rating : 4.38/5 ( download)

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Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Author : Harry Salem
Publisher : CRC Press
ISBN 13 : 0203008790
Total Pages : 616 pages
Book Rating : 4.99/5 ( download)

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Download or read book Alternative Toxicological Methods written by Harry Salem and published by CRC Press. This book was released on 2003-03-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist

Author : Ai-Lean Chew
Publisher : Springer Science & Business Media
ISBN 13 : 3540312943
Total Pages : 502 pages
Book Rating : 4.49/5 ( download)

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Download or read book Irritant Dermatitis written by Ai-Lean Chew and published by Springer Science & Business Media. This book was released on 2006-06-18 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Irritant dermatitis is a common condition, accounting for a significant proportion of occupational skin disease. The recent advent of non-invasive skin bioengineering technology has accelerated dermatology research in this field. This book comprises an exhaustive reference text on irritant contact dermatitis, covering all aspects of the condition: clinical features, epidemiology, prevention and therapy, prognosis, mechanisms, pathology and regulatory issues. The book also presents novel in vitro and in vivo research techniques and findings. As irritant dermatitis affects multiple specialties, the audience for this book is wide, including clinical and investigative dermatologists, allergists, toxicologists, pharmaceutical scientists, occupational and environmental physicians, public health physicians, cosmetologists and skin bioengineers.

Author : André Barel
Publisher : CRC Press
ISBN 13 : 0849354838
Total Pages : 1034 pages
Book Rating : 4.30/5 ( download)

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Download or read book Handbook of Cosmetic Science and Technology written by André Barel and published by CRC Press. This book was released on 2005-11-04 with total page 1034 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ranging from studies on the structure and function of the skin to research on a wide array of cosmetic compounds, this Second Edition updates readers on the latest regulatory guidelines, new cosmetic ingredients, state-of-the-art safety assessment technologies, and anticipated trends in the market-keeping pace with rapid advancements in chemistry,

Author : Bruno Sarmento
Publisher : John Wiley & Sons
ISBN 13 : 1119964075
Total Pages : 688 pages
Book Rating : 4.70/5 ( download)

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Download or read book Chitosan-Based Systems for Biopharmaceuticals written by Bruno Sarmento and published by John Wiley & Sons. This book was released on 2012-02-16 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chitosan is a linear polysaccharide commercially produced by the deacetylation of chitin. It is non-toxic, biodegradable, biocompatible, and acts as a bioadhesive with otherwise unstable biomolecules - making it a valuable component in the formulation of biopharmaceutical drugs. Chitosan-Based Systems for Biopharmaceuticals provides an extensive overview of the application of chitosan and its derivatives in the development and optimisation of biopharmaceuticals. The book is divided in four different parts. Part I discusses general aspects of chitosan and its derivatives, with particular emphasis on issues related to the development of biopharmaceutical chitosan-based systems. Part II deals with the use of chitosan and derivatives in the formulation and delivery of biopharmaceuticals, and focuses on the synergistic effects between chitosan and this particular subset of pharmaceuticals. Part III discusses specific applications of chitosan and its derivatives for biopharmaceutical use. Finally, Part IV presents diverse viewpoints on different issues such as regulatory, manufacturing and toxicological requirements of chitosan and its derivatives related to the development of biopharmaceutical products, as well as their patent status, and clinical application and potential. Topics covered include: chemical and technological advances in chitins and chitosans useful for the formulation of biopharmaceuticals physical properties of chitosan and derivatives in sol and gel states absorption promotion properties of chitosan and derivatives biocompatibility and biodegradation of chitosan and derivatives biological and pharmacological activity of chitosan and derivatives biological, chemical and physical compatibility of chitosan and biopharmaceuticals approaches for functional modification or crosslinking of chitosan use of chitosan and derivatives in conventional biopharmaceutical dosage forms manufacture techniques of chitosan-based microparticles and nanoparticles for biopharmaceuticals chitosan and derivatives for biopharmaceutical use: mucoadhesive properties chitosan-based systems for mucosal delivery of biopharmaceuticals chitosan-based delivery systems for mucosal vaccination chitosan-based nanoparticulates for oral delivery of biopharmaceuticals chitosan-based systems for ocular delivery of biopharmaceuticals chemical modification of chitosan for delivery of DNA and siRNA target-specific chitosan-based nanoparticle systems for nucleic acid delivery functional PEGylated chitosan systems for biopharmaceuticals stimuli-sensitive chitosan-based systems for biopharmaceuticals chitosan copolymers for biopharmaceuticals application of chitosan for anti-cancer biopharmaceutical delivery chitosan-based biopharmaceuticals scaffolds in tissue engineering and regenerative medicine wound healing properties of chitosan and its use in wound dressing biopharmaceuticals toxicological properties of chitosan and derivatives for biopharmaceutical applications regulatory status of chitosan and derivatives patentability and intellectual property issues quality control and good manufacturing practice preclinical and clinical use of chitosan and derivatives for biopharmaceuticals Chitosan-Based Systems for Biopharmaceuticals is an important compendium of fundamental concepts, practical tools and applications of chitosan-based biopharmaceuticals for researchers in academia and industry working in drug formulation and delivery, biopharmaceuticals, medicinal chemistry, pharmacy, bioengineering and new materials development.

Author : Klaus Peter Wilhelm
Publisher : CRC Press
ISBN 13 : 142000977X
Total Pages : 1044 pages
Book Rating : 4.74/5 ( download)

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Download or read book Dermatotoxicology written by Klaus Peter Wilhelm and published by CRC Press. This book was released on 2007-11-26 with total page 1044 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the embryonic state of the field, the first edition of Dermatoxicology, published in 1977, numbered 567 pages. Now the foundational reference in dermal toxicology, this seventh edition consists of 1,032 pages and defines what was once a largely intuitive field but has evolved into an established science of metrics and mechanisms. Updated

Author : Aaron Tabor
Publisher : William Andrew
ISBN 13 : 0815520301
Total Pages : 582 pages
Book Rating : 4.06/5 ( download)

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Download or read book Nutritional Cosmetics written by Aaron Tabor and published by William Andrew. This book was released on 2009-07-30 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutritional cosmetics is an emerging area of intense research and marketing and encompasses the concept that orally consumed dietary products can support healthier and more beautiful skin. There are numerous dietary ingredients now being marketed for their potential skin health and beauty benefits and many of these are supported by growing scientific evidence. The purpose of this book is to compile the scientific evidence showing the potential benefits of some of the more extensively researched ingredients. As far as possible, information about the benefits of ingredients consumed orally for skin health is presented. The information contained in this book will help provide insights into an emerging research area and provide scientific background for the potential clinical effectiveness for some of the better researched nutricosmetic ingredients. ABOUT THE EDITORS Aaron Tabor, M.D. is the CEO of Physicians Pharmaceuticals and author of The Revival Slim & Beautiful Diet. A graduate of the Johns Hopkins School of Medicine, Dr. Tabor oversees all clinical research on the Revival Slim & Beautiful Diet plan, conducting randomized, double-blinded, placebo-controlled studies at leading hospitals in the U.S. Areas of note include weight loss, skin/hair/nail appearance, energy, menopause, PMS, cholesterol, memory, and diabetic health. He is also responsible for directing new Revival product development based on clinical research results. Robert M. Blair, Ph.D. is the Research Manager for Physicians Pharmaceuticals, Inc. and manages the daily activities of the Research and Nutrition departments. Dr. Blair received his Ph.D. from Oklahoma State University in the field of Reproductive Physiology. Before joining Physicians Pharmaceuticals, Inc., he worked as an Assistant Professor of Comparative Medicine at the Wake Forest University School of Medicine where he examined the effects of dietary soy on cardiovascular health and cognitive function. Reviews the most-popular and most-researched nutricosmetic ingredients Presents information specifically about the benefits of ingredients consumed orally for skin health Considers the benefits of whey protein, rosemary, soy – and green tea and milk thistle, specifically, for protection against sun damage and photocarcinogenesis Provides information on antioxidants, incl: potential benefits of botanical antioxidants; carotenoids; coenzyme Q10; healthy fruits; olive fruit; and natural enzymes