Barriers And Channels Formed By Tight Junction Proteins

Author : Michael Fromm
Publisher : Wiley-Blackwell
ISBN 13 : 9781573318921
Total Pages : 0 pages
Book Rating : 4.22/5 ( download)

DOWNLOAD NOW!

Download or read book Barriers and Channels Formed by Tight Junction Proteins II, Volume 1258 written by Michael Fromm and published by Wiley-Blackwell. This book was released on 2012-07-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tight junction proteins connect epithelial and endothelial cells and, importantly, form selective barriers and channels for paracellular transportation. Two types of tight junction proteins—the claudin family (claudins-1 to -27) and the TAMP family (occludin, Marvel-D2, and tricellulin)—can be distinguished molecularly and functionally. Recent work has focused on delineating the functional significance of differences in selective permeability, for example, by examining the regulatory mechanisms of tight junctions. This work is of great clinical importance as many inflammatory or infectious diseases are characterized by increased permeability and the manipulation of tight junctions presents a new horizon in the development of novel therapeutics. The volume Barriers and Channels Formed by Tight Junction Proteins II provides a detailed look at the recent advances in our understanding of tight junction regulation and dysregulation. The papers included focus on three major themes: inflammation and gastrointestinal function; epithelial transport, barrier modulation, and food components; and tight junctions in intestinal and renal epithelia. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on instutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.

Author : Gwen Johnston
Publisher : Larsen and Keller Education
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.53/5 ( download)

DOWNLOAD NOW!

Download or read book Barriers and Channels Formed by Tight Junction Proteins written by Gwen Johnston and published by Larsen and Keller Education. This book was released on 2023-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tight junctions (TJ) are cell adhesion structures or junction structures that are located at the uppermost portion of the adjacent epithelial or endothelial cells in organs and tissues. TJs comprise a branched network of sealing strands, where every strand acts independently. The main function of TJs is maintaining the relative stability of intracellular substances. It functions by closing or opening the intercellular pathways and by coordinating the entry and exit of molecules of different sizes and charges. TJs are also responsible for regulating the permeability of the paracellular barrier, preventing microbial invasion, regulating cell proliferation, and maintaining cell polarity. TJ proteins connect endothelial and epithelial cells, and are also responsible for creating specific barriers and channels for paracellular transport. This book contains some path-breaking studies related to barriers and channels formed by tight junction proteins. It will serve as a valuable source of reference for graduate and postgraduate students.

Author : Michael Fromm
Publisher : Wiley-Blackwell
ISBN 13 : 9781573318921
Total Pages : 0 pages
Book Rating : 4.22/5 ( download)

DOWNLOAD NOW!

Download or read book Barriers and Channels Formed by Tight Junction Proteins II, Volume 1258 written by Michael Fromm and published by Wiley-Blackwell. This book was released on 2012-07-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tight junction proteins connect epithelial and endothelial cells and, importantly, form selective barriers and channels for paracellular transportation. Two types of tight junction proteins—the claudin family (claudins-1 to -27) and the TAMP family (occludin, Marvel-D2, and tricellulin)—can be distinguished molecularly and functionally. Recent work has focused on delineating the functional significance of differences in selective permeability, for example, by examining the regulatory mechanisms of tight junctions. This work is of great clinical importance as many inflammatory or infectious diseases are characterized by increased permeability and the manipulation of tight junctions presents a new horizon in the development of novel therapeutics. The volume Barriers and Channels Formed by Tight Junction Proteins II provides a detailed look at the recent advances in our understanding of tight junction regulation and dysregulation. The papers included focus on three major themes: inflammation and gastrointestinal function; epithelial transport, barrier modulation, and food components; and tight junctions in intestinal and renal epithelia. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on instutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.

Author :
Publisher :
ISBN 13 :
Total Pages : 191 pages
Book Rating : 4.25/5 ( download)

DOWNLOAD NOW!

Download or read book Barriers and Channels Formed by Tight Junction Proteins written by and published by . This book was released on 2012 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Tight junction proteins connect epithelial and endothelial cells and, importantly, form selective barriers and channels for paracellular transportation. Two types of tight junction proteins--the claudin family (claudins-1 to -27) and the TAMP family (occludin, Marvel-D2, and tricellulin)--can be distinguished molecularly and functionally. Recent work has focused on delineating the functional significance of differences in selective permeability, for example, by examining the regulatory mechanisms of tight junctions. This work is of great clinical importance as many inflammatory or infectious diseases are characterized by increased permeability and the manipulation of tight junctions presents a new horizon in the development of novel therapeutics. The volume Barriers and Channels Formed by Tight Junction Proteins II provides a detailed look at the recent advances in our understanding of tight junction regulation and dysregulation. The papers included focus on three major themes: inflammation and gastrointestinal function; epithelial transport, barrier modulation, and food components; and tight junctions in intestinal and renal epithelia"--Publisher description.

Author : Michael Fromm
Publisher : MDPI
ISBN 13 : 3039433008
Total Pages : 432 pages
Book Rating : 4.01/5 ( download)

DOWNLOAD NOW!

Download or read book The Tight Junction and Its Proteins: More Than Just a Barrier written by Michael Fromm and published by MDPI. This book was released on 2020-11-20 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.81/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Marilyn J. Cipolla
Publisher : Biota Publishing
ISBN 13 : 1615047239
Total Pages : 82 pages
Book Rating : 4.39/5 ( download)

DOWNLOAD NOW!

Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Author : Jörg-Dieter Schulzke
Publisher :
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.90/5 ( download)

DOWNLOAD NOW!

Download or read book Tight Junctions and Their Proteins written by Jörg-Dieter Schulzke and published by . This book was released on 2017 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Tight junctions between epithelial and endothelial cells form selective barriers. However, some tight junction proteins form ion or water channels that conduct through the otherwise sealed barrier between epithelial cells. Owning to this function they regulate paracellular transport of solutes, immune cells, and drugs. In various diseases tight junction proteins can be either up- or downregulated, and by this they aggravate, or even induce, pathogenesis. This special issues is the first of two presenting reviews and original research on tight junctions"--Publisher's description.

Author :
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.83/5 ( download)

DOWNLOAD NOW!

Download or read book Tight Junctions and Their Proteins written by and published by . This book was released on 2017 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Michael Fromm
Publisher :
ISBN 13 : 9783039433018
Total Pages : 432 pages
Book Rating : 4.16/5 ( download)

DOWNLOAD NOW!

Download or read book The Tight Junction and Its Proteins written by Michael Fromm and published by . This book was released on 2020 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ--mainly the two families of claudins and TAMPs--several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.