Atropisomerism And Axial Chirality

Author : Lassaletta Jose M
Publisher : World Scientific
ISBN 13 : 1786346478
Total Pages : 676 pages
Book Rating : 4.76/5 ( download)

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Download or read book Atropisomerism And Axial Chirality written by Lassaletta Jose M and published by World Scientific. This book was released on 2019-05-23 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atropisomerism and Axial Chirality provides a global survey of the chemistry of axially chiral compounds including biaryls, heterobiaryls, non-biaryl atropisomers, allenes and spyrocyclic derivatives. From the perspective of a synthetic organic chemist, this book provides a unique compilation of the available methodologies for their synthesis, with emphasis on the most efficient and modern strategies, a review of the huge amount of practical applications in the field of asymmetric catalysis, either as transition metal ligands or as organocatalysts, and an overview of their occurrence as bioactive compounds and natural products.The first of its kind, this book serves as a general introduction and a practical reference to advanced chemistry students and researchers, while also offering creative ideas for further developments in the field.

Author : José M. Lassaletta
Publisher : Wspc (Europe)
ISBN 13 : 9781786346452
Total Pages : 0 pages
Book Rating : 4.51/5 ( download)

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Download or read book Atropisomerism and Axial Chirality written by José M. Lassaletta and published by Wspc (Europe). This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atropisomerism and Axial Chirality provides a global survey of the chemistry of axially chiral compounds including biaryls, heterobiaryls, non-biaryl atropisomers, allenes and spyrocyclic derivatives. From the perspective of a synthetic organic chemist, this book provides a unique compilation of the available methodologies for their synthesis, with emphasis on the most efficient and modern strategies, a review of the huge amount of practical applications in the field of asymmetric catalysis, either as transition metal ligands or as organocatalysts, and an overview of their occurrence as bioactive compounds and natural products. The first of its kind, this book serves as a general introduction and a practical reference to advanced chemistry students and researchers, while also offering creative ideas for further developments in the field.

Author : Bin Tan
Publisher : John Wiley & Sons
ISBN 13 : 3527347127
Total Pages : 338 pages
Book Rating : 4.24/5 ( download)

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Download or read book Axially Chiral Compounds written by Bin Tan and published by John Wiley & Sons. This book was released on 2021-11-22 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Axially Chiral Compounds Explore this comprehensive and current volume summarizing the characteristics, synthesis, and applications of axial chirality Appearing widely in natural products, biologically active molecules, asymmetric chemistry, and material science, axially chiral motifs constitute the core backbones of the majority of chiral ligands and organocatalysts in asymmetric catalysis. In a new work of particular relevance to synthetic chemists, Axially Chiral Compounds: Asymmetric Synthesis and Applications delivers a clearly structured and authoritative volume covering the classification, characteristics, synthesis, and applications of axial chirality. A must read for every synthetic chemist practicing today, the book follows the development history, research status, and applications of axial chirality. An introductory chapter familiarizes the reader with foundational material before the distinguished authors describe the different classes and the synthesis of axial chiral compounds used in asymmetric synthesis. The book concludes with a focus on the applications of chiral ligands, chiral catalysts, and materials. Readers will also benefit from the inclusion of: A thorough introduction to asymmetric synthesis, including biaryls atropisomers, heterobiaryls atropisomers, and non-biaryls atropisomers Explorations of chiral allene, spiro skeletons, and natural products Practical discussions of asymmetric transformation, chiral ligands, and chiral catalysts An examination of miscellaneous applications of axially chiral compounds Perfect for organic chemists, chemists working with or on organometallics, catalytic chemists, and materials scientists, Axially Chiral Compounds: Asymmetric Synthesis and Applications will also earn a place in the libraries of natural products chemists who seek a one-stop reference for compounds exhibiting axial chirality.

Author : Ramarao Poduri
Publisher : Springer Nature
ISBN 13 : 9811555346
Total Pages : 522 pages
Book Rating : 4.43/5 ( download)

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Download or read book Drug Discovery and Development written by Ramarao Poduri and published by Springer Nature. This book was released on 2021-02-15 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Author : Michel F. Eichelbaum
Publisher : Springer Science & Business Media
ISBN 13 : 3642558429
Total Pages : 455 pages
Book Rating : 4.29/5 ( download)

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Download or read book Stereochemical Aspects of Drug Action and Disposition written by Michel F. Eichelbaum and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to guide and inspire drug researchers as they enter the 21st century. Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or medicines, stereoisomeric drugs offer invaluable insights or innovative therapeutic strategies. The book spans the subject from the molecular to the clinical. The first section on chemical aspects contains chapters on chemical synthesis, analysis, natural products, chiral stability (racemezation) and physical properties. The second section is on experimental pharmacology, with chapters on drug-receptor interactions, chiral recognition, ion channels, and molecular toxicology. The third section focuses on drug disposition, with chapters on absorption, distribution, protein binding, metabolism and elimination. The final section is dedicated to regulatory and clinical aspects.

Author : w Lough
Publisher : Springer Science & Business Media
ISBN 13 : 940090861X
Total Pages : 278 pages
Book Rating : 4.11/5 ( download)

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Download or read book Chiral Liquid Chromatography written by w Lough and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: While working as a chromatographer in the pharmaceutical industry, it became apparent to the editor that there was a pressing need for a comprehensive reference text for analysts working on the resolution of enantiomers by liquid chromatography (LC). This need arises from the fact that, whereas previously it was very difficult to determine enantiomers by direct means, there is now a wide choice of direct LC methods. At the same time, regulatory authorities have been changing their attitudes towards the administration of pharmaceuticals as racemates, partly because it is now possible to study the individual enantiomers. Clearly this abundance of new information needs to be rationalized. More importantly, the chiral LC systems which are commercially available or readily accessible to the practising chromatographer needed to be reviewed and, to a much greater extent than in existing reviews or books, discussed in terms of their practical application. Accordingly this book is very much orientated towards the practical aspects of these commercially available and readily accessible chiral LC systems. To this end, it is written for practising chromatographers by a team of practising, experienced chromatographers who have spent many years tackling the problems presented by resolving enantiomers by LC. The practical aspects of common chiral LC systems cannot be fully understood if discussed in isolation.

Author : Qi-Lin Zhou
Publisher : John Wiley & Sons
ISBN 13 : 3527635211
Total Pages : 670 pages
Book Rating : 4.14/5 ( download)

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Download or read book Privileged Chiral Ligands and Catalysts written by Qi-Lin Zhou and published by John Wiley & Sons. This book was released on 2011-02-10 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic asymmetric synthesis has been one of the most active research areas in chemistry (Nobel Prize in 2001). The development of efficient chiral catalysts plays a crucial role in asymmetric catalysis. Although many chiral ligands/catalysts have been developed in the past decades, the most efficient catalysts are derived from a few core structures, called "privileged chiral catalysts". This ultimate "must have" and long awaited reference for every chemist working in the field of asymmetric catalysis starts with the core structure of the catalysts, explaining why a certain ligand or catalyst is so successful. It describes in detail the history, the basic structural characteristics, and the applications of these "privileged catalysts". This novel presentation provides readers with a much deeper insight into the topic and makes it a must-have for organic chemists, catalytic chemists, chemists working with/on organometallics, chemists in industry, and libraries. From the contents: * BINAP * Bisphosphacycles - From DuPhos and BPE to a Diverse Set of Broadly Applied Ligands * Josiphos Ligands: From Discovery to Technical Applications * Chiral Spiro Ligands * Chiral Bisoxazoline Ligands * PHOX Ligands * Chiral Salen Complexes * BINOL * TADDOLate Ligands * Cinchona Alkaloids * Proline Derivatives

Author : Purvesh Shah
Publisher : GRIN Verlag
ISBN 13 : 3656660824
Total Pages : 37 pages
Book Rating : 4.28/5 ( download)

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Download or read book Stereochemistry. An Introduction written by Purvesh Shah and published by GRIN Verlag. This book was released on 2014-05-28 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt: Document from the year 2012 in the subject Chemistry - Organic Chemistry, grade: A-C, , language: English, abstract: Stereochemistry - An Introduction is the introduction about the Stereochemistry it includes, Axial Chirality, Atropisomers, Planar Chirality, Helical Chirality, Cyclosteroisomerism and Reteroenantio Isomerism.

Author : Patrick J. Walsh
Publisher : University Science Books
ISBN 13 : 9781891389542
Total Pages : 692 pages
Book Rating : 4.48/5 ( download)

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Download or read book Fundamentals of Asymmetric Catalysis written by Patrick J. Walsh and published by University Science Books. This book was released on 2009-01-02 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work describes the essential aspects of enantioselective catalysis, with chapters organised by concept rather than by reaction type. Each concept is supported by examples to give the reader broad exposure to a wide range of catalysts, reactions and reaction mechanisms.

Author : Michinori Oki
Publisher : Springer Science & Business Media
ISBN 13 : 3642510248
Total Pages : 261 pages
Book Rating : 4.43/5 ( download)

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Download or read book The Chemistry of Rotational Isomers written by Michinori Oki and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rotation about the Carbon-Carbon single bond is generally regarded to be unrestricted. About 50 years ago, rotational isomers were found to exhibit optical activity: substituted biphenyl derivatives. However, the author has investigated other classes of compounds that have stable rotational isomers at room temperature. These compounds can serve as models for studying very weak intermolecular interactions, that are difficult to observe. Even diastereotopic groups show different chemical reactivity. From the contents: The "Free Rotation Concept" - Rotamer Populations - Barriers to Rotation - Reactivity of Rotational Isomers.