Application And Integration Of Omics Powered Diagnostics In Clinical And Public Health Microbiology

Author : Jacob Moran-Gilad
Publisher : Springer Nature
ISBN 13 : 3030621553
Total Pages : 240 pages
Book Rating : 4.51/5 ( download)

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Download or read book Application and Integration of Omics-powered Diagnostics in Clinical and Public Health Microbiology written by Jacob Moran-Gilad and published by Springer Nature. This book was released on 2021-05-24 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Various “omics” methods have recently revolutionized molecular diagnostics. Next-generation sequencing (NGS) makes it possible to sequence a human genome in just one day. Whole genome sequencing (WGS) greatly improves the ability to investigate the outbreaks of numerous pathogens. Metagenomics helps to analyze the microbiome, which aids greatly in identifying the pathogenesis of infectious diseases. Proteomic-based methods, namely matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF-MS), have a promising role in identifying myctobacteria and fungi, and predicting antimicrobial resistance. While there are numerous scientific publications on “omics” applications for microbiology, there are relatively few books that review this topic from a clinical diagnostics perspective. This book looks at this field from a holistic viewpoint, instead of limiting by type of “omics” technology, in order to cover the body of knowledge needed for practitioners and academics interested in clinical and public health microbiology. Additionally, it addresses the management, economical, regulatory and operational aspects of integrating these technologies into routine diagnostics.

Author : Joana C. Prata
Publisher : Academic Press
ISBN 13 : 0128227958
Total Pages : 368 pages
Book Rating : 4.54/5 ( download)

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Download or read book One Health written by Joana C. Prata and published by Academic Press. This book was released on 2022-04-27 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: One Health: Challenges for the 21st Century is a transdisciplinary approach to health, considering the interdependency of human, animal, and environmental health. This approach to health promotion and disease prevention calls for integrative and interdisciplinary cooperation. From zoonotic diseases to environmental degradation, this book introduces core concepts of the One Health approach by presenting focal key challenges. The objective of this book is not centered solely on epidemiologic interactions of infectious diseases but also on the environmental and ecological implications of current major threats. Written by international experts, the ten chapters provide a comprehensive approach consisting of core concepts, practical examples, and applications that align with key challenges to public health. Therefore, this book is a valuable resource for public health professionals, veterinarians, physicians, environmental researchers, policymakers, and other professionals who seek to understand the overarching complexities of health. Examines the interconnection between humans, animals and the environment and how those relationships impact prevention, early detection, containment, and response to public health risks Offers concise and comprehensive coverage of the One Health concept, application to key public health challenges, and current and future developments Presents insights from an interdisciplinary group of international experts, containing examples to illustrate One Health framework and issues

Author : Karsten Becker
Publisher : Frontiers Media SA
ISBN 13 : 2832523749
Total Pages : 116 pages
Book Rating : 4.42/5 ( download)

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Download or read book MALDI-TOF MS in Microbiological Diagnostics: Future Applications Beyond Identification written by Karsten Becker and published by Frontiers Media SA. This book was released on 2023-05-18 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Varvara K. Kozyreva
Publisher : Frontiers Media SA
ISBN 13 : 2832544193
Total Pages : 147 pages
Book Rating : 4.98/5 ( download)

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Download or read book Integration of NGS in clinical and public health microbiology workflows: applications, compliance, quality considerations written by Varvara K. Kozyreva and published by Frontiers Media SA. This book was released on 2024-02-05 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: The expansion of NGS implementation in clinical and public health practice accelerated drastically during the SARS-CoV-2 pandemic, where NGS has been playing a vital role in tracking dangerous strains of the virus. NGS applications not only influenced public health decision-making but also have been crossing into the clinical field with individual patients’ results being potentially available to the physicians. Hence, the topic of implementation of NGS methods in clinical and public health microbiology, its challenges and special considerations, is as timely as ever. The use of Next Generation Sequencing (NGS) in clinical and public health microbiology laboratories has been steadily expanding in the past decade. However, this progress has been held back by multiple logistical challenges, like the absence of regulatory compliance framework, lack of clear quality guidelines, the need for standardization and interoperability between laboratories, as well as cost and turn-around-time limitations.

Author :
Publisher : Academic Press
ISBN 13 : 0128033312
Total Pages : 660 pages
Book Rating : 4.19/5 ( download)

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Download or read book Current and Emerging Technologies for the Diagnosis of Microbial Infections written by and published by Academic Press. This book was released on 2015-11-23 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current and Emerging Technologies in Microbial Diagnostics, the latest volume in the Methods in Microbiology series, provides comprehensive, cutting-edge reviews of current and emerging technologies in the field of clinical microbiology. The book features a wide variety of state-of-the art methods and techniques for the diagnosis and management of microbial infections, with chapters authored by internationally renowned experts. This volume focuses on current techniques, such as MALDI-TOF mass spectroscopy and molecular diagnostics, along with newly emerging technologies such as host-based diagnostics and next generation sequencing. Written by recognized leaders and experts in the field Provides a comprehensive and cutting-edge review of current and emerging technologies in the field of clinical microbiology, including discussions of current techniques such as MALDI-TOF mass spectroscopy and molecular diagnostics Includes a broad range and breadth of techniques covered Presents discussions on newly emerging technologies such as host-based diagnostics and next generation sequencing

Author : Paul A. Schulte
Publisher : Academic Press
ISBN 13 : 0323138578
Total Pages : 609 pages
Book Rating : 4.74/5 ( download)

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Download or read book Molecular Epidemiology written by Paul A. Schulte and published by Academic Press. This book was released on 2012-12-02 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.

Author : Mousumi Debnath
Publisher : Springer Science & Business Media
ISBN 13 : 9048132614
Total Pages : 527 pages
Book Rating : 4.14/5 ( download)

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Download or read book Molecular Diagnostics: Promises and Possibilities written by Mousumi Debnath and published by Springer Science & Business Media. This book was released on 2010-01-29 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: A rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.

Author : Debmalya Barh
Publisher : Academic Press
ISBN 13 : 0128047496
Total Pages : 645 pages
Book Rating : 4.91/5 ( download)

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Download or read book Omics Technologies and Bio-engineering written by Debmalya Barh and published by Academic Press. This book was released on 2017-12-01 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Omics Technologies and Bio-Engineering: Towards Improving Quality of Life, Volume 1 is a unique reference that brings together multiple perspectives on omics research, providing in-depth analysis and insights from an international team of authors. The book delivers pivotal information that will inform and improve medical and biological research by helping readers gain more direct access to analytic data, an increased understanding on data evaluation, and a comprehensive picture on how to use omics data in molecular biology, biotechnology and human health care. Covers various aspects of biotechnology and bio-engineering using omics technologies Focuses on the latest developments in the field, including biofuel technologies Provides key insights into omics approaches in personalized and precision medicine Provides a complete picture on how one can utilize omics data in molecular biology, biotechnology and human health care

Author : Michael Mahler
Publisher : Academic Press
ISBN 13 : 032385432X
Total Pages : 300 pages
Book Rating : 4.20/5 ( download)

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Download or read book Precision Medicine and Artificial Intelligence written by Michael Mahler and published by Academic Press. This book was released on 2021-03-12 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine

Author : Bruce R. Korf
Publisher : John Wiley & Sons
ISBN 13 : 1118537661
Total Pages : 280 pages
Book Rating : 4.64/5 ( download)

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Download or read book Human Genetics and Genomics written by Bruce R. Korf and published by John Wiley & Sons. This book was released on 2012-11-19 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of the best-selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions. A newly expanded Part 1, Basic Principles of Human Genetics, focuses on introducing the reader to key concepts such as Mendelian principles, DNA replication and gene expression. Part 2, Genetics and Genomics in Medical Practice, uses case scenarios to help you engage with current genetic practice. Now featuring full-color diagrams, Human Genetics and Genomics has been rigorously updated to reflect today’s genetics teaching, and includes updated discussion of genetic risk assessment, “single gene” disorders and therapeutics. Key learning features include: Clinical snapshots to help relate science to practice ‘Hot topics’ boxes that focus on the latest developments in testing, assessment and treatment ‘Ethical issues’ boxes to prompt further thought and discussion on the implications of genetic developments ‘Sources of information’ boxes to assist with the practicalities of clinical research and information provision Self-assessment review questions in each chapter Accompanied by the Wiley E-Text digital edition (included in the price of the book), Human Genetics and Genomics is also fully supported by a suite of online resources at www.korfgenetics.com, including: Factsheets on 100 genetic disorders, ideal for study and exam preparation Interactive Multiple Choice Questions (MCQs) with feedback on all answers Links to online resources for further study Figures from the book available as PowerPoint slides, ideal for teaching purposes The perfect companion to the genetics component of both problem-based learning and integrated medical courses, Human Genetics and Genomics presents the ideal balance between the bio-molecular basis of genetics and clinical cases, and provides an invaluable overview for anyone wishing to engage with this fast-moving discipline.