Apoptosis In Immunology

Author : Guido Kroemer
Publisher : Springer Science & Business Media
ISBN 13 : 3642794378
Total Pages : 242 pages
Book Rating : 4.77/5 ( download)

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Download or read book Apoptosis in Immunology written by Guido Kroemer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: In any movement of their life, immune cells, especially T and B lymphocytes, are confronted with an essential choice: to continue their existence or to commit a sort of metabolic suicide that is referred to as apoptosis or programmed cell death. In contrast to most philosophers, lymphocytes and their precursors are constantly susceptible to suicide, and it even appears that the usual cause of T or B cell elimination is suicide rather than death from natural causes, accidents or murder. This book provides a vast overview of lymphocytes suicide: external triggers and internal motives leading to suicidal impulses, accomplices in self-destruction, weapons implicated in self-execution, removal of dead bodies and pharmacological prevention of suicide. Most of the chapters in this book are devoted to the physiology of apoptosis. The goal is to unmask the external triggers of apoptosis, unravel the signal transduction pro cesses involved therein and describe the role of oncogenes, "death genes" and effector molecules in the apoptotic cas cade. The remaining chapters deal with the pathophysiologi cal aspects of lymphocyte apoptosis, namely, as a host contribution to HIV-induced lymphopenia, and therapeutic strategies for the avoidance of lymphocyte death. We are confident that this compendium will contribute to the exploration of cellular suicide, not only from a basic scientist's viewpoint but also with regard to the possible clinical implications of apoptosis (dys)regulation. Far from having a depressing effect on the reader, cellular suicide may thus provide a source of both intellectual excitement and therapeutic inspiration.

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.70/5 ( download)

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Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : C. S. Potten
Publisher : Cambridge University Press
ISBN 13 : 9780521626798
Total Pages : 240 pages
Book Rating : 4.9X/5 ( download)

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Download or read book Apoptosis written by C. S. Potten and published by Cambridge University Press. This book was released on 2004-08-16 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of programmed cell death, or apoptosis, has exploded into a major scientific field of interest for cell biologists, oncologists, and many other biomedical researchers. Apoptosis occurs throughout the lifetime of most multicellular organisms. During development, for example, the selective death of cells is vital to remove tissue between the digits to produce fingers and toes. Apoptosis is also necessary to destroy cells that represent a threat to the integrity of the organism, for example cells infected by a virus. In many cancers the genes regulating apoptosis are defective, producing immortal, continuously proliferating cells. This book discusses the philosophical and technical difficulties in defining the moment of death for a cell, as well as the biological implications and significance of programmed cell death. Recent developments in the genetic control and interacting gene networks associated with apoptosis are presented. The book is written for advanced undergraduate and postgraduate students, and is highly illustrated to aid understanding.

Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1489902740
Total Pages : 268 pages
Book Rating : 4.40/5 ( download)

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Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation VI written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since programmed cell death was first described in insects in 1964 and apoptosis was described in 1972, rapid progress has been made in understanding the basic mechanisms and genes regulating programmed cell death and apoptosis. In addition, defects in various genes regulating programmed cell death have been delineated in several experimental models of human diseases. This volume surveys various aspects of these rapidly developing areas of research in programmed cell death/apoptosis. This volume should be of interest to basic immunologists and molecular biologists. The volume begins with a historical perspective of cell death. The remainder of the volume is divided into four different parts. Part I deals with the signaling pathways in apoptosis, including cell cycle control of apoptosis, role of ceramide in apoptosis, role of antibody signaling, and biochemical regulation of apoptosis. The mechanisms for recognition of apoptotic lymphocytes by macrophages are also reviewed. Part II examines the role of various genes that regulate apoptosis, including the role ofFas, FasL, and other TNF family members in apoptosis and homeostatic regulation of immune response. Recently described splice variants and their influence on apoptosis are also reviewed, and the role of the members of the Bcl-2 family in apoptosis is discussed in detail. Part III reviews various aspects of apoptosis in B lymphocytes, including mechanisms that regulate apoptosis/survival of B lymphocytes and the regulation of Fas-mediated apoptosis in B lymphocytes.

Author : Keith B. Elkon
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805580363
Total Pages : 219 pages
Book Rating : 4.66/5 ( download)

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Download or read book Apoptosis and Its Relevance to Autoimmunity written by Keith B. Elkon and published by Karger Medical and Scientific Publishers. This book was released on 2006 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume highlights the recent advances in the basic mechanisms of apoptosis and the application of that knowledge to understanding the impact of defective apoptosis or defective clearance of apoptotic cells on the immune function and the expression of

Author : Joachim R. Kalden
Publisher : John Wiley & Sons
ISBN 13 : 3527605290
Total Pages : 392 pages
Book Rating : 4.93/5 ( download)

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Download or read book Apoptosis and Autoimmunity written by Joachim R. Kalden and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.

Author : Douglas R. Green
Publisher : Cambridge University Press
ISBN 13 : 1139498738
Total Pages : 470 pages
Book Rating : 4.39/5 ( download)

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Download or read book Apoptosis written by Douglas R. Green and published by Cambridge University Press. This book was released on 2011-08-22 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.

Author : Douglas R. Green
Publisher :
ISBN 13 : 9781621822141
Total Pages : 250 pages
Book Rating : 4.41/5 ( download)

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Download or read book Cell Death written by Douglas R. Green and published by . This book was released on 2018-09-30 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Cell Death, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. This new edition contains critical new information on recent exciting advances in the field, such as new forms for cell death and important insights into the mechanisms and control of apoptosis. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field.

Author : Diane E Griffin
Publisher : Springer Science & Business Media
ISBN 13 : 9783540230069
Total Pages : 312 pages
Book Rating : 4.68/5 ( download)

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Download or read book Role of Apoptosis in Infection written by Diane E Griffin and published by Springer Science & Business Media. This book was released on 2005-02-14 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This mechanism of programmed cell death plays an important role in normal development and control of cell numbers in mature animals. Initiation of the apoptotic process can come from external or internal stimuli and is highly regulated both by molecules that facilitate and by molecules that inhibit the process. It can be envisioned that apoptosis as a response to an intracellular pathogen is a useful way for the host to eliminate infected cells, decreasing the likelihood of spread of the infection to neighboring cells and preventing pathogen persistence. Alternatively, the apoptotic response may be a major mechanism by which the host is harmed by a pathogen.

Author : Christopher D. Gregory
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 440 pages
Book Rating : 4.50/5 ( download)

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Download or read book Apoptosis and the Immune System written by Christopher D. Gregory and published by Wiley-Liss. This book was released on 1995-03-02 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: By offering a broad range of views, Apoptosis and the Immune Response presents a current and complete picture of the various aspects and consequences of this phenomenon.