Antiviral Chemotherapy

Author : John Mills
Publisher : Springer Science & Business Media
ISBN 13 : 1461547431
Total Pages : 266 pages
Book Rating : 4.33/5 ( download)

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Download or read book Antiviral Chemotherapy 5 written by John Mills and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists and clinicians attending the last "New Directions in Antiviral Therapy" conference in late 1994 could hardly have predicted the revolution in the management of patients with HIV infection that has occurred since. Two new classes of antiretrovirals have been licensed, the second-site RT inhibitors and the protease inhibitors; the long in cubation period of active HIV infection, when the infection is clinically latent, is now un derstood to be a period of intense viral replication and turnover of CD4 lymphocytes; measurements of HI V RNA concentration in plasma have been shown to be essential tools for monitoring the course of HIV infection, deciding when to treat, and assessing the re sults of treatment; and finally, combinations of antiretrovirals, particularly combinations including protease inhibitors, have been shown to have dramatically beneficial effects on patients with HIV infection. These advances, coupled with new drugs for the management of herpesvirus infections, have made dramatic differences in the quality and length of life of HIV-infected patients. Additional advances have been made since 1994 in the prevention or management of influenza virus (zanamavir), respiratory syncytial virus (palvizumab), hepatitis B virus (lamivudine and famciclovir), and enterovirus infections (pleconaril). It is difficult to re member that only slightly more than a decade ago there were only a handful of antiviral agents available (none of which were antiretrovirals), and a number of those were either highly toxic, of dubious efficacy, or both.

Author : John Mills
Publisher : Springer Science & Business Media
ISBN 13 : 1475792093
Total Pages : 432 pages
Book Rating : 4.96/5 ( download)

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Download or read book Antiviral Chemotherapy 4 written by John Mills and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three years since our last conference in San Francisco have again seen a dramatic expansion of the number of antivirals either licensed or in the late stages of clinical trials. d4T is now licensed for HIV infection, famciclovir and the oral pro-drug of acyclovir, valacyclovir, are now licensed for VZV infections in some countries. Moreover. oral ganciclovir, cidofovir, and sorivudine are not far behind. Clinical trials with the second-site reverse transcriptase inhibitors and the protease inhibitors for HlV infection are proceeding rapidly and on a broad scale, and the preliminary results would suggest that several of these classes of drugs will be licensed as well. Despite this optimism, however, there is increasing evidence that antiviral-resistant strains of pathogenic viruses will be a significant problem, perhaps especially with therapy of HIV infection, and there remains a desperate need for improved drugs (with either improved efficacy or decreased toxicity, or both) for CMV and HIV infections. This book is the edited proceedings of the Fourth Triennial Conference on Antiviral Chemotherapy, held in San Francisco, in November 1994. The conference was sponsored by the University of California, San Francisco, and co-sponsored by the International Society for Antiviral Research (ISAR), the Macfarlane Burnet Centre for Medical Research in Melbourne, Australia, and the Australian National Centre for HIV Virology Research. The conference had been organized to present an overview of the field of antiviral chemotherapy.

Author : P E. Came
Publisher : Springer Science & Business Media
ISBN 13 : 3642684874
Total Pages : 580 pages
Book Rating : 4.76/5 ( download)

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Download or read book Chemotherapy of Viral Infections written by P E. Came and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: " . . . the motto for the therapeutics of the future will have to be de sedibus et causis pharmacorum. " P. EHRLICH, 1909 Exciting events in the basic disciplines of virology, immunology, and pharmacology continue to advance the understanding of the pathogenesis and control of virus diseases. At the same time, the rational development of antiviral agents is attracting, to an increasing extent, the interest of workers in other disciplines. Improvements in technology facilitate the definition of potential target sites for antiviral intervention and unmask new viral and host genes. The outcome is a further steady development of new antiviral agents which approach the "magic bullets" first proposed by PAUL EHRLICH. Remarkable advances in protein synthetic methods that yield polypeptides which inhibit active sites of viral proteins have aided substantially in the basic and clinical study of these antiviral agents. In addition, the extremely rapid progression in recombinant DNA techniques, leading to the synthesis of large quantities of gene products, is also increasing our opportunities at a dashing pace. New information and developing technology facilitate research on the mechanism of action, toxicity, pharmacokinetics, and pharmacodynamics of new agents. The list of clinically effective antiviral agents is expanding and the number of potentially useful compounds is growing rapidly. This book is a combined theoretical text and practical manual which, it is hoped, will be of use to all who have an interest in virus diseases, particularly scientists, physicians and graduate students.

Author : D. J. Jeffries
Publisher :
ISBN 13 :
Total Pages : 614 pages
Book Rating : 4.74/5 ( download)

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Download or read book Antiviral Chemotherapy written by D. J. Jeffries and published by . This book was released on 1995-07-11 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable advances have been made in the treatment of antiviral diseases over the last decade. Several new drugs have been introduced while new clinical information has been gathered on the efficacy of existing drugs. This study aims to provide an examination of the basic science (drug formulae, structure and biochemical activity) and clinical information (usage and efficacy) on chemotherapy, as well as describing future potentials.

Author : Richard Challand
Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.91/5 ( download)

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Download or read book Antiviral Chemotherapy written by Richard Challand and published by . This book was released on 1997 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: A textbook for an upper-level or graduate course for students with a background in chemistry or biochemistry. Traces the history of antivirals and presents the current understanding of viral biochemistry, the mechanisms of small molecules and their development as drugs, and the application of various types of chemical therapies. Includes a glossary without pronunciation. Annotation copyrighted by Book News, Inc., Portland, OR

Author : K. K. Gauri
Publisher :
ISBN 13 :
Total Pages : 398 pages
Book Rating : 4.76/5 ( download)

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Download or read book Antiviral Chemotherapy written by K. K. Gauri and published by . This book was released on 1981 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Hugh J. Field
Publisher :
ISBN 13 :
Total Pages : 146 pages
Book Rating : 4.95/5 ( download)

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Download or read book Antiviral Agents written by Hugh J. Field and published by . This book was released on 1988 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.41/5 ( download)

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Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Author : David Shugar
Publisher : Pergamon
ISBN 13 :
Total Pages : 596 pages
Book Rating : 4.95/5 ( download)

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Download or read book Viral Chemotherapy written by David Shugar and published by Pergamon. This book was released on 1984 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author :
Publisher :
ISBN 13 :
Total Pages : 412 pages
Book Rating : 4.16/5 ( download)

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Download or read book Antiviral Chemotherapy written by and published by . This book was released on 1963 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: