Antisense Nucleic Acids And Proteins

Author : Joseph N. M. Mol
Publisher : CRC Press
ISBN 13 : 9780824785161
Total Pages : 256 pages
Book Rating : 4.69/5 ( download)

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Download or read book Antisense Nucleic Acids and Proteins written by Joseph N. M. Mol and published by CRC Press. This book was released on 1991-01-24 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: A compilation of papers from many different scientific meetings in recent years, this reference source reviews the use of antisense nucleic acids to modulate or down-regulate gene expression, provides clues on the action mechanism of sense and antisense genes as well as data on antisense nucleic aci

Author : Joseph N. M. Mol
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.59/5 ( download)

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Download or read book Antisense Nucleic Acids and Proteins written by Joseph N. M. Mol and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Christopher Janson
Publisher : Springer Science & Business Media
ISBN 13 : 0387329560
Total Pages : 286 pages
Book Rating : 4.67/5 ( download)

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Download or read book Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules written by Christopher Janson and published by Springer Science & Business Media. This book was released on 2007-03-06 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.

Author : Eric Wickstrom
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.45/5 ( download)

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Download or read book Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS written by Eric Wickstrom and published by Wiley-Liss. This book was released on 1991-10-18 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wide range of new technology involving a direct genetic approach to the treatment of disease using nucleic acid therapeutics is the main focus of this absorbing book. Provides in-depth coverage of the rapid progress of this new technology, from its theoretical stage to its current position at the verge of experimental applications, along with provocative discussions of the therapeutic implications.

Author : A. G. Hernandes
Publisher : Nova Publishers
ISBN 13 : 9781600214912
Total Pages : 246 pages
Book Rating : 4.16/5 ( download)

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Download or read book Antisense Elements (genetics) Research Focus written by A. G. Hernandes and published by Nova Publishers. This book was released on 2007 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antisense molecules interact with complementary strands of nucleic acids, modifying expression of genes. Some regions within a double strand of DNA code for genes, which are usually instructions specifying the order of amino acids in a protein along with regulatory sequences, splicing sites, non-coding introns and other complicating details. For a cell to use this information, one strand of the DNA serves as a template for the synthesis of a complementary strand of RNA. The template DNA strand is called the transcribed strand with antisense sequence and the mRNA transcript is said to be sense sequence (the complement of antisense). Because the DNA is double-stranded, the strand complementary to the antisense sequence is called non-transcribed strand and has the same sense sequence as the mRNA transcript (though T bases in DNA are substituted with U bases in RNA). This book presents important new research from around the world in this field.

Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470515406
Total Pages : 260 pages
Book Rating : 4.02/5 ( download)

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Download or read book Oligonucleotides as Therapeutic Agents written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery of protein synthesis either by binding to the mRNAs transcribed from a gene or by binding directly to a target gene. This approach can be used not only for inhibition of the synthesis of host proteins but also of those required by invading pathogens. Potential therapeutic applications are enormous, ranging over hypertension, cardiovascular disease, autoimmune disease, vital and other parasitic infections (especially HIV), and cancer. This book discusses the chemistry and pharmacokinetics of oligonucleotides and their analogues, and surveys the results of structure-activity studies and current clinical trials. It also critically reviews the problems with antisense therapy, such as the enzymatic destruction of oligonucleotides, the doses required for a therapeutic response, the difficulty in directing oligonucleotides to particular target tissues and cells, the need for parenteral administration, and doubts concerning the mechanism of action (especially problems associated with non-specific binding to proteins) and long-term effects.

Author : Stanley T. Crooke
Publisher : CRC Press
ISBN 13 : 9780849347054
Total Pages : 620 pages
Book Rating : 4.5X/5 ( download)

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Download or read book Antisense Research and Applications written by Stanley T. Crooke and published by CRC Press. This book was released on 1993-05-27 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antisense Research and Applications is a comprehensive review of oligonucleotide research covering molecular biological advances in this field, the current status of antisense drug research, and strategies for future research and therapeutic applications. In bringing together the latest research from an array of authoritative scientists, Antisense Research and Applications provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered in the 32 chapters of this book include nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonucleotides, analogs, pharmacokinetics and toxicology, and activities of current antisense drugs. This volume addresses advances in a broad range of disciplines and is an excellent resource for basic researchers and applied investigators in pharmaceutical laboratories and in such fields as biochemistry and molecular biology.

Author : Stanley T. Crooke
Publisher : CRC Press
ISBN 13 : 1439832501
Total Pages : 848 pages
Book Rating : 4.09/5 ( download)

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Download or read book Antisense Drug Technology written by Stanley T. Crooke and published by CRC Press. This book was released on 2007-07-25 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generati

Author : Saghir Akhtar
Publisher : CRC Press
ISBN 13 : 1351366130
Total Pages : 393 pages
Book Rating : 4.37/5 ( download)

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Download or read book Delivery Strategies for Antisense Oligonucleotide Therapeutics written by Saghir Akhtar and published by CRC Press. This book was released on 2017-07-28 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.

Author : Ram I. Mahato
Publisher : CRC Press
ISBN 13 : 1135487847
Total Pages : 911 pages
Book Rating : 4.43/5 ( download)

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Download or read book Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids written by Ram I. Mahato and published by CRC Press. This book was released on 2004-12-28 with total page 911 pages. Available in PDF, EPUB and Kindle. Book excerpt: Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases. Introducing the principles of polymer science and chemistry, this book delineates the basic biology required for understanding how biomaterials can be used as drug-deliver vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Leading experts from around the world discuss the physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The book includes coverage biological barriers to extravasation and cellular uptake of proteins and nucleic acids.