Anti Aids Drug Development

Author : Prem Mohan
Publisher : CRC Press
ISBN 13 : 9783718656981
Total Pages : 312 pages
Book Rating : 4.81/5 ( download)

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Download or read book Anti-AIDS Drug Development written by Prem Mohan and published by CRC Press. This book was released on 1995-03-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Curative anti-AIDS drug therapy still remains as an unconquered hurdle to drug research. This book covers significant aspects that are involved in the search, design and development of potential anti-AIDS agents with emphasis on areas related to drug development. These include enzyme inhibitors (reverse transcriptase, protease, glucosidase), inhibitors of gene expression (oligonucleotides), viral-binding inhibitors (anionic compounds and CD4 mimetics) and various plant derived products. A focus of this book is the medicinal chemistry of these classes of compounds. In addition, other areas that are pertinent to drug development are also addressed. These include HIV regulatory proteins, the development of anti-HIV-1 assays and resistance to anti-HIV-1 agents.

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309044901
Total Pages : 84 pages
Book Rating : 4.05/5 ( download)

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Download or read book Expanding Access to Investigational Therapies for HIV Infection and AIDS written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: The call for a "parallel track" for AIDS drug developmentâ€"a proposal that would allow the early distribution of AIDS drugs to large numbers of patients in parallel with the conventional clinical trials that assess the drugs' safety and efficacyâ€"has sparked controversy within the scientific community. Questions have arisen about the risks to patients of such a plan, about its potential effect on the successful completion of standard controlled trials, and about whether the parallel track will generate useful data. Larger questions have also been raised about whether the parallel track heralds fundamental changes in the philosophy underlying drug regulation in the United States, about the costs and financing of investigational therapies and associated medical costs, and about the role of expanded access mechanisms for drugs in reaching those whose health care is generally inadequate. This volume summarizes a conference hosted by the Institute of Medicine that illuminated these issues.

Author : Peter S. Arno
Publisher : HarperCollins Publishers
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.84/5 ( download)

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Download or read book Against the Odds written by Peter S. Arno and published by HarperCollins Publishers. This book was released on 1993 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Against the Odds is the most important book yet written about the quest for a cure and treatments for AIDS. Authors Arno and Feiden cut through the complex issues to tell the tragic, inspiring story behind the scenes of the AIDS crisis - how a diverse group of extraordinary people banded together to fight bureaucracy and greed to save lives. AIDS has been called the greatest public health menace of our time, and yet political and bottom-line agendas, couples with fear, racism, and homophobia, have made the battle against it a painful uphill struggle. Against the Odds is the tale of government officials, agencies, and pharmaceutical companies that have delayed the development of life-saving and life-prolonging drugs, and of others who have bent and changed the rules. Most of all, it is the story of the activist and patient communities that have now altered the course of government policy toward AIDS and other diseases with their creative, and often heroic, tactics"--Unedited summary from book.

Author : King K. Holmes
Publisher : World Bank Publications
ISBN 13 : 1464805253
Total Pages : 506 pages
Book Rating : 4.57/5 ( download)

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Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309046289
Total Pages : 337 pages
Book Rating : 4.82/5 ( download)

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Download or read book The Social Impact of AIDS in the United States written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Europe's "Black Death" contributed to the rise of nation states, mercantile economies, and even the Reformation. Will the AIDS epidemic have similar dramatic effects on the social and political landscape of the twenty-first century? This readable volume looks at the impact of AIDS since its emergence and suggests its effects in the next decade, when a million or more Americans will likely die of the disease. The Social Impact of AIDS in the United States addresses some of the most sensitive and controversial issues in the public debate over AIDS. This landmark book explores how AIDS has affected fundamental policies and practices in our major institutions, examining: How America's major religious organizations have dealt with sometimes conflicting values: the imperative of care for the sick versus traditional views of homosexuality and drug use. Hotly debated public health measures, such as HIV antibody testing and screening, tracing of sexual contacts, and quarantine. The potential risk of HIV infection to and from health care workers. How AIDS activists have brought about major change in the way new drugs are brought to the marketplace. The impact of AIDS on community-based organizations, from volunteers caring for individuals to the highly political ACT-UP organization. Coping with HIV infection in prisons. Two case studies shed light on HIV and the family relationship. One reports on some efforts to gain legal recognition for nonmarital relationships, and the other examines foster care programs for newborns with the HIV virus. A case study of New York City details how selected institutions interact to give what may be a picture of AIDS in the future. This clear and comprehensive presentation will be of interest to anyone concerned about AIDS and its impact on the country: health professionals, sociologists, psychologists, advocates for at-risk populations, and interested individuals.

Author : World Health Organization
Publisher :
ISBN 13 : 9789241549684
Total Pages : 429 pages
Book Rating : 4.88/5 ( download)

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Download or read book Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection written by World Health Organization and published by . This book was released on 2016 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: These guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, treatment and care. This edition updates the 2013 consolidated guidelines on the use of antiretroviral drugs following an extensive review of evidence and consultations in mid-2015, shared at the end of 2015, and now published in full in 2016. It is being published in a changing global context for HIV and for health more broadly.

Author : José das Neves
Publisher : CRC Press
ISBN 13 : 9814463566
Total Pages : 709 pages
Book Rating : 4.60/5 ( download)

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Download or read book Drug Delivery and Development of Anti-HIV Microbicides written by José das Neves and published by CRC Press. This book was released on 2014-10-16 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: The worldwide impact of HIV/AIDS is well recognized. This book provides for the first time a thorough and critical overview of current aspects, recent developments, and trends in the formulation and drug delivery concerning anti-HIV microbicides by leading scientists in the field. Additionally, pertinent regulatory aspects and socioeconomical issues related to the subject are discussed. In the absence of a cure, prophylaxis represents a cornerstone in the battle against infection. One promising strategy comprises the use around the time of sexual intercourse of vaginal/rectal products containing antiviral compounds, termed microbicides. It is now recognized that specific development of drug dosage forms and/or drug delivery systems is an indispensable aspect for the success of microbicides. Different groups strived over the last decade to optimize the biophysical and technological performance of traditional dosage forms (gels, tablets, and suppositories) to fulfill the specificities of microbicides use, without neglecting users’ preferences and affordability issues. Moreover, new formulation approaches, such as vaginal rings and films, nanotechnology-based systems, stimuli-sensitive formulations, targeted drug delivery systems, among others have been proposed and are currently undergoing pre-clinical or even clinical testing.

Author : José das Neves
Publisher : MDPI
ISBN 13 : 3039219006
Total Pages : 208 pages
Book Rating : 4.01/5 ( download)

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Download or read book Novel Approaches for the Delivery of Anti-HIV Drugs written by José das Neves and published by MDPI. This book was released on 2020-05-20 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: HIV/AIDS continues to be one of the most challenging individual and public health concerns of the present day. According to the UNAIDS, nearly 38 million individuals were living with the infection by the end of 2018, while 1.7 million new cases occurred during that same year. In spite of the numerous advances in the development and delivery of antiretroviral agents, both for treatment and prevention, several challenges remain. This book includes original research and review articles on innovative strategies and approaches for the formulation and delivery of anti-HIV drugs, including genetic material and other biopharmaceuticals. Different local and systemic delivery strategies are addressed based on different technologies intended for oral, transdermal, subcutaneous, vaginal, or rectal administration. Authored by eminent scientists in academia and nonprofit organizations involved in the development of antiretroviral drug products, this collection provides useful information for all those involved in HIV/AIDS treatment and prevention.

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.74/5 ( download)

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Download or read book Government and Industry Collaboration in AIDS Drug Development written by and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1608058964
Total Pages : 300 pages
Book Rating : 4.69/5 ( download)

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Download or read book Frontiers in Clinical Drug Research: HIV written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2015-04-02 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Clinical Drug Research – HIV is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other disorders associated with human immunodeficiency virus (HIV) infection. The scope of the eBook series covers a range of topics including the medicinal chemistry and pharmacology of natural and synthetic drugs employed in the treatment of AIDS (including HAART) and resulting complications, and the virology and immunological study of HIV and related viruses. Frontiers in Clinical Drug Research – HIV is a valuable resource for pharmaceutical scientists, clinicians and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in HIV/AIDS research. The first volume of this series features 7 chapters that cover a variety of topics including: -Antiretroviral drug development -HIV-1 genomics -HIV drug targets such as ribosomes and HIV Integrase -HAART associated nephrotoxicity