Annual Reports In Combinatorial Chemistry And Molecular Diversity

Author : W.H. Moos
Publisher : Springer Science & Business Media
ISBN 13 : 0306469049
Total Pages : 376 pages
Book Rating : 4.46/5 ( download)

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Download or read book Annual Reports in Combinatorial Chemistry and Molecular Diversity written by W.H. Moos and published by Springer Science & Business Media. This book was released on 1997-04-30 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed, more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. This first volume covers: (i) combinatorial chemistry, (ii) combinatorial biology and evolution, and (iii) informatics and related topics. Within each section chapters are prepared by experts in the field, including, for example, in Section I: Coverage of mixture pools vs. parallel individual compound synthesis, solution vs. solid-phase synthesis, analytical tools, and automation. Section II highlights selection strategies and library-based evolution, phage display, peptide and nucleic acid libraries. Section III covers databases and library design, high through-put screening, coding strategies vs. deconvolutions, intellectual property issues, deals and collaborations, and successes to date.

Author : M.R. Pavia
Publisher : Springer
ISBN 13 : 9780792357223
Total Pages : 188 pages
Book Rating : 4.21/5 ( download)

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Download or read book Annual Reports in Combinatorial Chemistry and Molecular Diversity written by M.R. Pavia and published by Springer. This book was released on 1999-06-30 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combinatorial chemistry and molecular diversity approaches to scientific and novel product R & D have exploded in the 1990s. For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. The second volume in this series includes contributions on methods, solid phases, purification, analysis, carbohydrates, patent strategies and tactics, diversity profiling and combinatorial series design, and finishes with a survey of chemical libraries yielding biologically active agents and a compendium of solid phase chemistry publications. Each contribution is prepared by a recognized expert resulting in a high quality account of the recent advances in the field.

Author : W.H. Moos
Publisher : Springer Science & Business Media
ISBN 13 : 9789072199232
Total Pages : 376 pages
Book Rating : 4.35/5 ( download)

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Download or read book Annual Reports in Combinatorial Chemistry and Molecular Diversity written by W.H. Moos and published by Springer Science & Business Media. This book was released on 1997-04-30 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed, more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. This first volume covers: (i) combinatorial chemistry, (ii) combinatorial biology and evolution, and (iii) informatics and related topics. Within each section chapters are prepared by experts in the field, including, for example, in Section I: Coverage of mixture pools vs. parallel individual compound synthesis, solution vs. solid-phase synthesis, analytical tools, and automation. Section II highlights selection strategies and library-based evolution, phage display, peptide and nucleic acid libraries. Section III covers databases and library design, high through-put screening, coding strategies vs. deconvolutions, intellectual property issues, deals and collaborations, and successes to date.

Author : Irwin M. Chaiken
Publisher :
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.08/5 ( download)

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Download or read book Molecular Diversity and Combinatorial Chemistry written by Irwin M. Chaiken and published by . This book was released on 1996 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reports progress on chemical, enzymatic, phage, and cell-derived libra ries. Discusses synergy between structure-based design and combinatori al libraries. Presents applications of combinatorial libraries to drug discovery and new synthetic catalysis. Reports library screening appr oaches, including the use of NMR. Presents recent advances in solid-ph ase organic synthesis, liquid-phase organic synthesis, and high-throug hput combinatorial organic synthesis. Discusses automation of organic synthesis as well as new methodologies for monitoring solid-phase orga nic synthesis.

Author : Michael C. Pirrung
Publisher : Elsevier
ISBN 13 : 9780080445328
Total Pages : 196 pages
Book Rating : 4.22/5 ( download)

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Download or read book Molecular Diversity and Combinatorial Chemistry written by Michael C. Pirrung and published by Elsevier. This book was released on 2004-10-17 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.

Author : Stanislav Miertus
Publisher : CRC Press
ISBN 13 : 0824758374
Total Pages : 616 pages
Book Rating : 4.70/5 ( download)

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Download or read book Combinatorial Chemistry and Technologies written by Stanislav Miertus and published by CRC Press. This book was released on 2005-04-12 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities. Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies. Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.

Author :
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.64/5 ( download)

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Download or read book Annual Reports in Combinatorial Chemistry and Molecular Diversity written by and published by . This book was released on 1997 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Michael E. Swartz
Publisher : CRC Press
ISBN 13 : 0824746694
Total Pages : 314 pages
Book Rating : 4.98/5 ( download)

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Download or read book Analytical Techniques in Combinatorial Chemistry written by Michael E. Swartz and published by CRC Press. This book was released on 2000-02-18 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume aims to provide the necessary tools for developing methods and analyzing results in the drug discovery process, and supports documenting and managing the process in a combinatorial setting. It describes the chromatographic and spectroscopic techniques used to generate chemical and molecular diversity in new compounds, focusing on applications of information management systems, instrumentation, and robotics.

Author : Stanislav Miertus
Publisher : CRC Press
ISBN 13 : 9781420000566
Total Pages : 456 pages
Book Rating : 4.6X/5 ( download)

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Download or read book Combinatorial Chemistry and Technology written by Stanislav Miertus and published by CRC Press. This book was released on 1999-07-01 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."

Author :
Publisher : Elsevier
ISBN 13 : 9780080862842
Total Pages : 308 pages
Book Rating : 4.45/5 ( download)

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Download or read book Progress in Medicinal Chemistry written by and published by Elsevier. This book was released on 1999-05-14 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Medicinal Chemistry