Animal Models Of T Cell Mediated Skin Diseases

Author : T. Zollner
Publisher : Springer Science & Business Media
ISBN 13 : 3540268111
Total Pages : 302 pages
Book Rating : 4.16/5 ( download)

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Download or read book Animal Models of T Cell-Mediated Skin Diseases written by T. Zollner and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.

Author : Lawrence S. Chan
Publisher : CRC Press
ISBN 13 : 9781135510275
Total Pages : 584 pages
Book Rating : 4.7X/5 ( download)

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Download or read book Animal Models of Human Inflammatory Skin Diseases written by Lawrence S. Chan and published by CRC Press. This book was released on 2003-12-29 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in understanding skin diseases has been aided enormously by the use of tissues derived from animals, by studying normal processes in animals, and by the development of animal models. The cellular activities in animals and humans are remarkably similar and the actual pathological process of an inflammatory skin disease can only be accurately observed and analyzed in a living animal model, and not in any in vitro model system. These factors have led to the regular use of animal tissues and models to allow the disease processes to be studied at a much greater depth. Animal Models of Human Inflammatory Skin Diseases features the principles and practices of how to go about studying inflammatory skin diseases using live animal models. On the principle side, the book describes the comparative structure and function of the skin, and the comparative immunology system in animal species commonly used as models. From the practical perspective, it presents a general discussion on methods of experimental animal modeling and contains specific expert experience on individual models. The authors include a detailed method of disease induction for each model, present chapters on comparative histology and immunology, and discuss potential targets of disease intervention. Written by biomedical investigators with first-hand experience in their chosen fields, this book is a valuable guide and reference for investigators in the biomedical and pharmaceutical sciences. It provides an instantaneous comparison between the skin structure and immunology of humans and animals, aiding in the interpretation and application of pathologic and immunologic findings.

Author : Irun R. Cohen
Publisher : Academic Press
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.67/5 ( download)

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Download or read book Autoimmune Disease Models written by Irun R. Cohen and published by Academic Press. This book was released on 1994 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in this comprehensive guide. Certain to be an aid in the planning of individual experiments and broader research programs, this book will be a valuable addition to the library of all practicing immunologists interested in immune system function and dysfunction.

Author : Wolfram Sterry
Publisher : John Wiley & Sons
ISBN 13 : 0470657367
Total Pages : 286 pages
Book Rating : 4.62/5 ( download)

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Download or read book Psoriasis written by Wolfram Sterry and published by John Wiley & Sons. This book was released on 2014-12-15 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical and user-friendly, this is the ideal guide to the diagnosis and treatment of psoriasis, helping you navigate a logical management pathway through a complex maze of possibilities. Psoriasis is a cruel disease that can seriously affect the sufferer’s quality and length of life. It is also highly idiosyncratic, with features that vary greatly from patient to patient; this being mirrored in the highly variable response to treatment. It is increasingly recognized that psoriasis is not a discrete disease and that many patients suffer two or three comorbid conditions that can complicate the efforts of doctors treating patients. Psoriasis: Diagnosis and Management will provide dermatologists of all levels with a practical, well-illustrated approach to fully understanding the disease, including clear, clinical guidance to enable best-practice and effective management of patients. In full color throughout and excellently illustrated, key highlights include: easily understandable description of the psoriasis pathogenesis; a strong emphasis on the clinical features of psoriasis; careful consideration of comorbid conditions as part of the psoriatic spectrum to be managed; coverage of both traditional and contemporary management approaches; plenty of diagnostic algorithms and management protocols to aid the daily practical care of patients. Brought to you by several of the world’s leading authorities on the subject, Psoriasis: Diagnosis and Management is an essential purchase for the dermatologist.

Author : Anthony Gaspari
Publisher : Springer Science & Business Media
ISBN 13 : 1848001657
Total Pages : 812 pages
Book Rating : 4.57/5 ( download)

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Download or read book Clinical and Basic Immunodermatology written by Anthony Gaspari and published by Springer Science & Business Media. This book was released on 2008-11-05 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dermatologists are being asked to understand the pathophysiology of a number of immune-mediated skin diseases. In addition, a number of new products have appeared on the market during the past decade which requires an understanding of the mechanisms of action of these drugs. Dermatologists, however, have no easily understood book to which they can refer to regarding the disease or the drug.

Author : John P. Sundberg
Publisher : CRC Press
ISBN 13 : 9780849383724
Total Pages : 582 pages
Book Rating : 4.22/5 ( download)

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Download or read book Handbook of Mouse Mutations with Skin and Hair Abnormalities written by John P. Sundberg and published by CRC Press. This book was released on 1994-05-19 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects. The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.

Author : Günter Burg
Publisher : Springer Science & Business Media
ISBN 13 : 3642607527
Total Pages : 418 pages
Book Rating : 4.23/5 ( download)

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Download or read book Strategies for Immunointerventions in Dermatology written by Günter Burg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent progress in the fields of pharmacology and immunology has provided us with new possibilities for treating dermatological diseases. This book reviews the most important immunosuppressive and immunostimulatory drugs and gives helpful, practical information on the treatment of various dermatoses, including autoimmundiseases, atopic dermatitis, psoriasis, vasculitis, contact dermatitis, pyoderma gangrenosum, infectious diseases, and neoplasms of the skin - in particular, malignant melanoma.

Author : Alexander Sigalov
Publisher : Springer Science & Business Media
ISBN 13 : 0387097899
Total Pages : 380 pages
Book Rating : 4.93/5 ( download)

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Download or read book Multichain Immune Recognition Receptor Signaling written by Alexander Sigalov and published by Springer Science & Business Media. This book was released on 2008-12-16 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.

Author : Yoshiaki Toyama
Publisher : Springer Nature
ISBN 13 : 9811379084
Total Pages : 292 pages
Book Rating : 4.86/5 ( download)

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Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.

Author :
Publisher :
ISBN 13 :
Total Pages : 912 pages
Book Rating : 4.57/5 ( download)

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Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1988 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: