Angiogenesis Lymphangiogenesis And Clinical Implications

Author : G. Marone
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318024813
Total Pages : 246 pages
Book Rating : 4.14/5 ( download)

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Download or read book Angiogenesis, Lymphangiogenesis and Clinical Implications written by G. Marone and published by Karger Medical and Scientific Publishers. This book was released on 2013-10-21 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis, the formation of new blood vessels, is fundamental for physiological processes such as embryonic and postnatal development, wound repair, and reproductive functions. Angiogenesis plays a major role in tumor growth and in several autoimmune and allergic disorders. Lymphangiogenesis, the formation of new lymphatic vessels, is also important for tumor growth, the formation of metastasis, and chronic inflammatory diseases. Judah Folkman, a pioneer in the study of angiogenesis, first proposed that macrophages and mast cells could be a relevant source of angiogenic factors. Since then, much effort has gone into the elucidation of the role of immune cells in the modulation of angiogenesis and lymphangiogenesis. There is now compelling evidence that several components of the innate and adaptive immune system are implicated in inflammatory and neoplastic angiogenesis and lymphangiogenesis. Articles in this volume deal with the emerging, intriguing possibility that immune cells are both a source and a target of angiogenic and lymphangiogenic factors. Therefore, cells of the immune system might play a role in inflammatory and neoplastic angiogenesis/lymphangiogenesis through the expression of several angiogenic factors and their receptors and co-receptors. The important new findings in this volume will be of special interest to vascular biologists, basic and clinical immunologists, oncologists and to specialists in allergic and immune disorders.

Author : Enrique Zudaire
Publisher : Springer Science & Business Media
ISBN 13 : 9400745818
Total Pages : 436 pages
Book Rating : 4.10/5 ( download)

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Download or read book The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications written by Enrique Zudaire and published by Springer Science & Business Media. This book was released on 2012-11-29 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis and lymphangiogenesis have become attractive targets for drug therapy because of their key roles in a broad spectrum of pathological disease states ranging from macular degeneration to tumor growth and metastasis. A substantial increase in the research effort over the past decade has deepened our understanding of the basic mechanisms underlying angiogenesis and lymphangiogenesis, promoting the development of promising therapeutics for the clinical management of vascular-related diseases. These extraordinary advancements have been built upon a vast array of diverse analytical techniques developed globally throughout the field. Over the years, these methods have evolved to suit the specific needs of different researchers and experimental scenarios, resulting in a myriad of technical variants of basic assay approaches. "The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications" is an up-to-date comprehensive textbook on angiogenesis and lymphangiogenesis techniques and applications. This volume is designed to embody the collective works of experts in the clinical as well as the basic research arenas who have significantly contributed to the development and application of techniques in all areas of angiogenesis and lymphangiogenesis. Each chapter introduces and discusses one or a group of closely related techniques and convey step-by-step protocol information and detailed technical guidance to the reader. Emphasis has been placed on explanatory illustrations, critical technical steps as well as divulging information on the benefits and caveats of specific practices related to the methods discussed. This manual is intended to serve as a written guide for both newcomers and established professionals in the field.

Author : I.D. Goldberg
Publisher : Birkhäuser
ISBN 13 : 3034890060
Total Pages : 437 pages
Book Rating : 4.69/5 ( download)

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Download or read book Regulation of Angiogenesis written by I.D. Goldberg and published by Birkhäuser. This book was released on 2013-03-12 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: We now know that excessive angiogenesis contributes to the development of a variety of disease processes, including cancer, chronic inflammatory disease, and diabetic retinopathy. On the other hand, insufficient angiogenesis may impair wound healing and organ repair. This volume describes recent advances in understanding the molecular regulation of angiogenesis. Subjects covered include important pro-angiogenic growth factors (e.g., vascular endothelial growth factor/vascular permeability factor, scatter factor/hepatocyte growth factor) and their receptors; angiogenesis inhibitors (e.g., thrombospondin-1, angiostatin); extracellular matrix factors (e.g., laminin) and specific vascular integrins (avb3 and avb5) that regulate angiogenesis; the roles of fibrin and the fibrinolytic system in angiogenesis; physical factors that regulate angiogenesis (hypoxia, pH); mechanisms by which specific cell types (macrophages, pericytes) regulate angiogenesis; and lymphangiogenesis, a subject often ignored in volumes of this type. Several chapters are also devoted to the prognostic and therapeutic implications of tumor angiogenesis, a subject of great interest to clinicians. Reflecting the latest advances in this exciting and expanding field, this comprehensive and authoritative monograph will prove invaluable to cell biologists, cancer researchers and pharmacologists.

Author : Napoleone Ferrara
Publisher : CRC Press
ISBN 13 : 1420004379
Total Pages : 304 pages
Book Rating : 4.73/5 ( download)

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Download or read book Angiogenesis written by Napoleone Ferrara and published by CRC Press. This book was released on 2006-08-15 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why a new book on angiogenesis and why now? For the first time concepts proposed over 30 years ago have found clinical validation. In the last two years the first antiangiogenic agents have been approved by the FDA for the treatment of cancer and age-related macular degeneration. Not surprisingly, this clinical success has raised a new set of basic

Author : Steven A. Stacker
Publisher : Springer Science & Business Media
ISBN 13 : 9048122473
Total Pages : 255 pages
Book Rating : 4.79/5 ( download)

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Download or read book Lymphangiogenesis in Cancer Metastasis written by Steven A. Stacker and published by Springer Science & Business Media. This book was released on 2009-09-30 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells. The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi’s sarcoma, and approaches for imaging lymphatics in cancer. The book also covers the innovative approaches taken by researchers to explore new roles for lymphatic vessel biology in the context of cancer. The information presented in this volume, which describes the revolutionary concepts of tumor lymphangiogenesis, will be of interest to all students, scientists and oncologists who are seeking to understand the complexities of tumor metastasis. Key Features: Presents fundamental concepts of tumor lymphangiogenesis and the molecules which control this process Provides a comprehensive summary of current research in this ground breaking area Provides a book which links progress in basic tumor and developmental biology with current and future oncology practise Is an essential text for molecular biologists, cell biologists and oncologists seeking to understand the implications of this rapidly developing area.

Author : Enrique Zudaire
Publisher : Springer
ISBN 13 : 9789400745803
Total Pages : 440 pages
Book Rating : 4.0X/5 ( download)

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Download or read book The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications written by Enrique Zudaire and published by Springer. This book was released on 2012-11-28 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis and lymphangiogenesis have become attractive targets for drug therapy because of their key roles in a broad spectrum of pathological disease states ranging from macular degeneration to tumor growth and metastasis. A substantial increase in the research effort over the past decade has deepened our understanding of the basic mechanisms underlying angiogenesis and lymphangiogenesis, promoting the development of promising therapeutics for the clinical management of vascular-related diseases. These extraordinary advancements have been built upon a vast array of diverse analytical techniques developed globally throughout the field. Over the years, these methods have evolved to suit the specific needs of different researchers and experimental scenarios, resulting in a myriad of technical variants of basic assay approaches. "The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications" is an up-to-date comprehensive textbook on angiogenesis and lymphangiogenesis techniques and applications. This volume is designed to embody the collective works of experts in the clinical as well as the basic research arenas who have significantly contributed to the development and application of techniques in all areas of angiogenesis and lymphangiogenesis. Each chapter introduces and discusses one or a group of closely related techniques and convey step-by-step protocol information and detailed technical guidance to the reader. Emphasis has been placed on explanatory illustrations, critical technical steps as well as divulging information on the benefits and caveats of specific practices related to the methods discussed. This manual is intended to serve as a written guide for both newcomers and established professionals in the field.

Author : Jawahar L. Mehta
Publisher : Springer
ISBN 13 : 3319611151
Total Pages : 548 pages
Book Rating : 4.50/5 ( download)

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Download or read book Biochemical Basis and Therapeutic Implications of Angiogenesis written by Jawahar L. Mehta and published by Springer. This book was released on 2017-08-28 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest developments in the therapeutic implications of angiogenesis, ranging from angiogenesis in the brain, angiogenesis in cancer, angiogenesis’ role in atherosclerosis and heart disease as well as metabolic disorders and peripheral vascular disease. The book is comprehensive in its coverage of angiogenesis in a diverse set of diseases and examines the role of cellular and subcellular structures during the development of angiogenesis. Well-organized and thorough, this is an ideal book for researchers and biomedical engineers working in the field of therapeutic implications of angiogenesis. This book also: Covers the basics of the physiology of angiogenesis, including VEGF pathways in angiogenesis, integr ins in angiogenesis, angiogenesis and exercise physiology, and more Details the role of angiogenesis in atherosclerosis and heart disease, including vascular endothelial growth factor and atherosclerotic plaque progression as well as angiogenesis and heart failure Illustrates in detail brain angiogenesis after stroke and the relationship between angiogenesis and Alzheimer's disease

Author : Alfredo Martínez
Publisher : IOS Press
ISBN 13 : 9789051993608
Total Pages : 410 pages
Book Rating : 4.09/5 ( download)

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Download or read book Adrenomedullin written by Alfredo Martínez and published by IOS Press. This book was released on 1998 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adrenomedullin is a recently discovered peptide hormone which involved in many physiological and pathological processes. This book reviews all the information available on this intriguing molecule, covering topics as diverse as blood pressure regulation, growth of tumours and normal cells, the central nervous system, and comparative studies from sharks to mammals. An international group of experts has contributed to this volume which will be of interest to professionals, researchers, and those who will benefit from a broad review of the literature and the main trends in adrenomedullin research.

Author : Carolyn A. Staton
Publisher : John Wiley & Sons
ISBN 13 : 047002934X
Total Pages : 410 pages
Book Rating : 4.43/5 ( download)

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Download or read book Angiogenesis Assays written by Carolyn A. Staton and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

Author : Daniele M. Gilkes
Publisher : Springer
ISBN 13 : 3030127346
Total Pages : 160 pages
Book Rating : 4.43/5 ( download)

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Download or read book Hypoxia and Cancer Metastasis written by Daniele M. Gilkes and published by Springer. This book was released on 2019-06-14 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.