Agave Negatively Regulates Yap And Taz Transcriptionally And Post Translationally In Osteosarcoma Cell Lines

Author : Maria Ferraiuolo
Publisher : Sapienza Università Editrice
ISBN 13 : 8893772450
Total Pages : 102 pages
Book Rating : 4.57/5 ( download)

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Download or read book Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines written by Maria Ferraiuolo and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are required. Previously published works indicate that Agave exhibits anticancer properties. In the present study, anticancer effects of Agave leaf extract were investigated in the OS cells, discovering that Agave inhibits cell growth and cell migration, and sensitizes OS cells to cisplatin (CDDP), to overcome chemoresistance. Agave’s mechanisms of action include an initial process in which Agave induces YAP/TAZ oncogenic protein degradation, followed by a secondary event whereby Agave inhibits YAP/TAZ transcription through NF-κB p65:p50 heterodimers deregulation. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.

Author : Ludovica Monti
Publisher : Sapienza Università Editrice
ISBN 13 : 8893772426
Total Pages : 354 pages
Book Rating : 4.26/5 ( download)

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Download or read book Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS-Directed Therapies written by Ludovica Monti and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules are essential cellular constituents of eukaryotes formed by tubulin subunits. This book is a collection of medicinal chemistry research projects that utilizes microtubules as drug targets for human diseases of global health impact. The main chapters (2 – 4) include an in-depth description of different synthetic and biological approaches to characterize the therapeutic potential of novel synthetic molecules for cancer, Alzheimer’s disease, and neglected tropical diseases. This book also includes three short chapters (5 – 7) of additional collaborative projects focused on varied drug discovery topics, including SAR studies of new lead compounds targeting carbonic anhydrase enzymes, FAAH and TRPV1, and novel bioisosteres of the carboxylic acid functional group.

Author : Eleonora Cella
Publisher : Sapienza Università Editrice
ISBN 13 : 8893772442
Total Pages : 160 pages
Book Rating : 4.40/5 ( download)

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Download or read book Multi-drug resistant Klebsiella pneumoniae strains circulating in hospital setting written by Eleonora Cella and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbapenems resistant Enterobacteriaceae infections are increasing worldwide representing an emerging public health problem. The application of phylogenetic and phylodynamic analyses to bacterial whole genome sequencing (WGS) data have become essential in epidemiological surveillance of MDR pathogens to discern outbreak from non-outbreak strains in both community and hospital settings. In this study, K. pneumoniae strains circulating within different wards of university hospital were collected and WGS applied. Moreover a microbiological surveillance on duedonoscopes was performed to evaluate their reprocessing. The aim was to infer the origin and the spread of K. pneumoniae nosocomial strains and to clarify the epidemiological transmission as so as the eventual reservoir in the hospital setting supporting the epidemiological surveillance and infections control strategies. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.

Author : Danilo Quartullo
Publisher : Sapienza Università Editrice
ISBN 13 : 8893772434
Total Pages : 220 pages
Book Rating : 4.33/5 ( download)

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Download or read book Simulations of RF Beam Manipulations Including Intensity Effects for CERN PSB and SPS Upgrades written by Danilo Quartullo and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The LIU program at CERN is of paramount importance at international level. The program foresees a significant upgrade of the LHC injector chain to increase the luminosity of the LHC beam by a factor of ten after 2024, when the HL-LHC era will start. This thesis deals with longitudinal beam dynamics studies for two LHC injectors (PSB and SPS), the main goal being the analysis of beam instabilities in the HL-LHC scenario.

Author : Massimiliano Mancini
Publisher : Sapienza Università Editrice
ISBN 13 : 8893772485
Total Pages : 285 pages
Book Rating : 4.88/5 ( download)

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Download or read book Towards Recognizing New Semantic Concepts in New Visual Domains written by Massimiliano Mancini and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite being the leading paradigm in computer vision, deep neural networks are inherently limited by the visual and semantic information contained in their training set. In this thesis, we aim to design deep models operating with previously unseen visual domains and semantic concepts. We first describe different solutions for generalizing to new visual domains, applying variants of normalization layers to multiple challenging settings e.g. where new domain data is not available but arrives online or is described by metadata. In the second part, we incorporate new semantic concepts into pretrained deep models. We propose specific solutions for different problems such as multi-task/incremental learning and open-world recognition. Finally, we merge the two challenges: given images of multiple domains and categories, can we recognize unseen concepts in unseen domains? We propose an approach that is the first, promising step, towards solving this problem. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.

Author : Tiziana de Rogatis
Publisher : Sapienza Università Editrice
ISBN 13 : 8893772558
Total Pages : 376 pages
Book Rating : 4.56/5 ( download)

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Download or read book Trauma Narratives in Italian and Transnational Women’s Writing written by Tiziana de Rogatis and published by Sapienza Università Editrice. This book was released on 2022-12-14 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is the first to propose new readings of Italian and transnational female-authored texts through the lens of Trauma Studies. Illuminating a space that has so far been left in the shadows, Trauma Narratives in Italian and Transnational Women’s Writing provides new insights into how the trope of trauma shapes the narrative, temporal and linguistic dimension of these works. The various contributions delineate a landscape of female-authored Italian and transnational trauma narratives and their complex textual negotiation of suffering and pathos, from the twentieth century to the present day. These zones of trauma engender a new aesthetics and a new reading of history and cultural memory as an articulation of female creativity and resistance against a dominant cultural and social order.

Author : Piero Picci
Publisher : Springer Science & Business Media
ISBN 13 : 3319017489
Total Pages : 370 pages
Book Rating : 4.88/5 ( download)

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Download or read book Atlas of Musculoskeletal Tumors and Tumorlike Lesions written by Piero Picci and published by Springer Science & Business Media. This book was released on 2014-01-18 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reflects the experience of the Rizzoli Orthopedic Institute during more than 100 years of treatment of musculoskeletal tumor and tumorlike lesions. It presents a wide range of lesions from a multidisciplinary perspective, highlighting pertinent clinical, radiological, and histological correlations. Treatment is briefly reported for each entity. In addition, the more recent biomolecular findings of use for diagnosis, prognosis, and treatment are carefully analyzed. The Rizzoli case archive spans more than a century, the first treated case dating back to 28 September 1900, and contains the original material – clinical charts, imaging, paraffin blocks, and histological slides – of more than 40,000 cases, including about 29,000 bone lesions and 11,000 soft tissue lesions. This book reports the most relevant entities and reflects the improvements in knowledge of musculoskeletal tumors as presented during the yearly international course held at the Rizzoli Institute.​

Author : David Ward
Publisher : Fairleigh Dickinson Univ Press
ISBN 13 : 9780838636763
Total Pages : 260 pages
Book Rating : 4.64/5 ( download)

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Download or read book Antifascisms written by David Ward and published by Fairleigh Dickinson Univ Press. This book was released on 1996 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an in-depth analysis of three of the most crucial years in twentieth-century Italian history, the years 1943-46. After more than two decades of a Fascist regime and a disastrous war experience during which Italy changed sides, these years saw the laying of the political and cultural foundations for what has since become known as Italy's First Republic. Drawing on texts from the literature, film, journalism, and political debate of the period, Antifascisms offers a thorough survey of the personalities and positions that informed the decisions taken in this crucial phase of modern Italian history.

Author : Saman Warnakulasuriya
Publisher : Springer
ISBN 13 : 9789402414851
Total Pages : 0 pages
Book Rating : 4.51/5 ( download)

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Download or read book Squamous cell Carcinoma written by Saman Warnakulasuriya and published by Springer. This book was released on 2018-07-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide. This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.

Author :
Publisher :
ISBN 13 :
Total Pages : 536 pages
Book Rating : 4.23/5 ( download)

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Download or read book Tile & Till written by and published by . This book was released on 1915 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: