3d Cell Based Biosensors In Drug Discovery Programs

Author : William S. Kisaalita
Publisher : CRC Press
ISBN 13 : 1420073508
Total Pages : 404 pages
Book Rating : 4.08/5 ( download)

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Download or read book 3D Cell-Based Biosensors in Drug Discovery Programs written by William S. Kisaalita and published by CRC Press. This book was released on 2010-06-22 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D Cell-Based Bio

Author : Qingjun Liu
Publisher : Artech House
ISBN 13 : 1596934409
Total Pages : 291 pages
Book Rating : 4.05/5 ( download)

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Download or read book Cell-based Biosensors written by Qingjun Liu and published by Artech House. This book was released on 2009-10 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.

Author : Huangxian Ju
Publisher : World Scientific
ISBN 13 : 9811237727
Total Pages : 997 pages
Book Rating : 4.20/5 ( download)

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Download or read book Biochemical Sensors (In 2 Volumes) written by Huangxian Ju and published by World Scientific. This book was released on 2021-06-08 with total page 997 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the full scope of biochemical sensors and offers a survey of the principles, design and applications of the most popular types of biosensing devices. It is presented in 19 chapters, written by 20 distinguished scientists as well as their co-workers. The topics include the design of signal transducers, signal tags and signal amplification strategies, the structure of biosensing interfaces with new biorecognition elements such as aptamers and DNAzymes, and different newly emerging nanomaterials such as Au nanoclusters, carbon nitride, silicon, upconversion nanoparticles and two-dimensional materials, and the applications in wearable detections, biofuel cells, biomarker analyses, bioimaging, single cell analysis and in vivo sensing.By discussing recent advances, it is hoped this book will bridge the common gap between research literature and standard textbooks. Research into biochemical sensors and their biomedical applications is proceeding in a number of exciting directions, as reflected by the content. This book is published in honor of the 90th birthday of Professor Shaojun Dong, who performed many pioneering studies on modified electrodes and biochemical sensors.

Author : Arun K. Bhunia
Publisher : Elsevier
ISBN 13 : 0857098071
Total Pages : 550 pages
Book Rating : 4.78/5 ( download)

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Download or read book High Throughput Screening for Food Safety Assessment written by Arun K. Bhunia and published by Elsevier. This book was released on 2014-09-06 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in array-based detectors and imaging technologies have provided high throughput systems that can operate within a substantially reduced timeframe and other techniques that can detect multiple contaminants at one time. These technologies are revolutionary in terms of food safety assessment in manufacturing, and will also have a significant impact on areas such as public health and food defence. This book summarizes the latest research and applications of sensor technologies for online and high throughput screening of food. The book first introduces high throughput screening strategies and technology platforms, and discusses key issues in sample collection and preparation. The subsequent chapters are then grouped into four sections: Part I reviews biorecognition techniques; Part II covers the use of optical biosensors and hyperspectral imaging in food safety assessment; Part III focuses on electrochemical and mass-based transducers; and finally Part IV deals with the application of these safety assessment technologies in specific food products, including meat and poultry, seafood, fruits and vegetables. Summarises the latest research on sensor technologies for online and high-throughput screening of food Covers high-throughput screening and the current and forecast state of rapid contaminant detection technologies Looks at the use of optical and electrochemical biosensors and hyperspectral imaging in food safety assessment and the application of these technologies in specific food products

Author : William Kisaalita
Publisher : Cambridge Scholars Publishing
ISBN 13 : 1527558940
Total Pages : 307 pages
Book Rating : 4.46/5 ( download)

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Download or read book Development Engineering written by William Kisaalita and published by Cambridge Scholars Publishing. This book was released on 2020-08-28 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details the development and evaluation of technological interventions designed to improve human and economic development within complex, low-resource settings, showing that a solution becomes an innovation when it reaches widespread use. The book shortens the time-gap between development and up-take of the intervention, especially for student solution-developers or innovators who are new to the cultural and geopolitical settings of the problem-source country or region. Technological interventions in development are sustainable if they meet a real need, are affordable by the users, fit within the cultural context and are ergonomically appropriate. Many interventions have failed because of inattentiveness to one or more of these factors. Each of the book’s points is backed up with scholarly research work, confidently guiding solution-developers confronted with issues such as acquiring intellectual property protections, among many others.

Author : Sean V. Murphy
Publisher : CRC Press
ISBN 13 : 1498711928
Total Pages : 459 pages
Book Rating : 4.20/5 ( download)

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Download or read book Regenerative Medicine Technology written by Sean V. Murphy and published by CRC Press. This book was released on 2016-11-30 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery. This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.

Author : Z. Aguilar
Publisher : The Electrochemical Society
ISBN 13 : 160768537X
Total Pages : 262 pages
Book Rating : 4.71/5 ( download)

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Download or read book Chemical and Biological Sensors 11 -and- MEMS/NEMS 11 written by Z. Aguilar and published by The Electrochemical Society. This book was released on 2014 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Shimshon Belkin
Publisher : Springer
ISBN 13 : 3642123627
Total Pages : 208 pages
Book Rating : 4.27/5 ( download)

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Download or read book Whole Cell Sensing Systems I written by Shimshon Belkin and published by Springer. This book was released on 2010-07-13 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Table of Contents Reporter cells: - Yeast Based Sensors by Mifumi Shimomura-Shimizu and Isao Karube - Mammalian Cell-Based Sensor Systems by Pratik Banerjee, Briana Franz, and Arun K. Bhunia - Fluorescent and Bioluminescent Cell-Based Sensors: Strategies for Their Preservation by Amol Date, Patrizia Pasini, and Sylvia Daunert - Electrochemical Cell-Based Sensors by Eliora Z. Ron and Judith Rishpon - Microbial Cell Arrays by Tal Elad, Jin Hyung Lee, Man Bock Gu, and Shimshon Belkin Devices: - Surface Functionalization for Protein and Cell Patterning by Pascal Colpo , Ana Ruiz , Laura Ceriotti , and François Rossi - Fiber-Optic Based Cell Sensors by Evgeni Eltzov and Robert S. Marks - Electronic Interfacing with Living Cells by James T. Fleming - On-Chip Detection of Cellular Activity by R. Almog , R. Daniel , S. Vernick , A. Ron , H. Ben-Yoav, and Y. Shacham-Diamand

Author : Matthew Cooper
Publisher : John Wiley & Sons
ISBN 13 : 1119990270
Total Pages : 357 pages
Book Rating : 4.77/5 ( download)

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Download or read book Label-Free Technologies For Drug Discovery written by Matthew Cooper and published by John Wiley & Sons. This book was released on 2011-02-11 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery. Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis. Label-Free Technologies For Drug Discovery is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.

Author : Ye Fang
Publisher : Humana
ISBN 13 : 9781493949618
Total Pages : 0 pages
Book Rating : 4.16/5 ( download)

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Download or read book Label-Free Biosensor Methods in Drug Discovery written by Ye Fang and published by Humana. This book was released on 2016-10-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores label-free biosensors, advantageous in part because this technology bypasses the need of labels, reporters, and cell engineering, all of which are common to labeled techniques but may introduce artifacts in assay results. Addressing several fundamental and practical aspects as to how to implement label-free methods in the drug discovery process, this book covers a wide range of topics, including binding kinetics determination, fragment screening, antibody epitope mapping, protein-protein interaction profiling and screening, receptor pathway deconvolution, drug pharmacology profiling and screening, target identification, drug toxicity assessment, and physical phenotype profiling and diagnostics based on various cellular processes such as cell adhesion, migration, invasion, infection, and inflammation. As part of the Methods in Pharmacology and Toxicology series, chapters aim to provide key detail and implementation advice to aid with progress in the lab. Practical and thorough, Label-Free Biosensor Methods in Drug Discovery provides a new avenue for rapid access to a focused collection of highly regarded contributions in the field.